The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Nuclear Localization of p38 MAPK in Response to DNA Damage
Open accessAbstract
p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cycle checkpoints. The intracellular localization of p38 MAPK upon activation remains unclear, and may depend on the stimulus. We show here that activation of p38 MAPK by stimuli that induce DNA double strand breaks (DSBs), but not other stimuli, leads to its nuclear translocation. In addition, naturally occurring DSBs generated through V(D)J recombination in immature thymocytes also promote nuclear accumulation of p38 MAPK. Nuclear translocation of p38 MAPK does not require its catalytic activity, but is induced by a conformational change of p38 MAPK triggered by phosphorylation within the active site. The selective nuclear accumulation of p38 MAPK in response to DNA damage could be a mechanism to facilitate the phosphorylation of p38 MAPK nuclear targets for the induction of a G2/M cell cycle checkpoint and DNA repair.
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Cites
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555 · cited 1×
“This phosphorylation is mediated primarily by upstream MKK3 and MKK6, although in vitro, MKK4 may also contribute to p38 MAPK activation in the absence of MKK3/MKK6 [6-8].”
BackgroundSelf-citationCarney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226
Quantitative Detection of125IdU-Induced DNA Double-Strand Breaks with γ-H2AX Antibody
Sedelnikova, O. A., Rogakou, E. P., Panyutin, I. G., & Bonner, W. M. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)158[0486:qdoiid]2.0.co;2 · Cited by 611
Cited by
p38 MAPK Signaling in Osteoblast Differentiation
Rodríguez-Carballo, E., Gámez, B., & Ventura, F. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00040 · Cited by 316
Rajaram, M. V. S., Ni, B., Morris, J. D., Brooks, M. N., Carlson, T. K., Bakthavachalu, B., Schoenberg, D. R., Torrelles, J. B., & Schlesinger, L. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112660108 · Cited by 269
Yokota, T., & Wang, Y. (2016) · Gene · doi:10.1016/j.gene.2015.09.030 · Cited by 127
Metadata
- Authors
- Wood, C. D., Thornton, T. M., Sabio, G., Davis, R. A., & Rincon, M.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2009
- Volume
- 5
- Issue
- 5
- Pages
- 428-437
- ISSN
- 1449-2288 (ISSN-L)
- OpenAlex
- W2132675424
- Cited by
- 169
- References
- 4
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wood, C. D., Thornton, T. M., Sabio, G., Davis, R. A., & Rincon, M. (2009). Nuclear Localization of p38 MAPK in Response to DNA Damage. International Journal of Biological Sciences. https://doi.org/10.7150/ijbs.5.428
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