Risk and Benefit of Drug Use During Pregnancy
Open accessAbstract
Environmental teratogenic factors (e.g. alcohol) are preventable. We focus our analysis on human teratogenic drugs which are not used frequently during pregnancy. The previous human teratogenic studies had serious methodological problems, e.g. the first trimester concept is outdated because environmental teratogens cannot induce congenital abnormalities in the first month of gestation. In addition, teratogens usually cause specific congenital abnormalities or syndromes. Finally, the importance of chemical structures, administrative routes and reasons for treatment at the evaluation of medicinal products was not considered. On the other hand, in the so-called case-control epidemiological studies in general recall bias was not limited. These biases explain that the teratogenic risk of drugs is exaggerated, while the benefit of medicine use during pregnancy is underestimated. Thus, a better balance is needed between the risk and benefit of drug treatments during pregnancy. Of course, we have to do our best to reduce the risk of teratogenic drugs as much as possible, however, it is worth stressing the preventive effect of drugs for maternal diseases (e.g. diabetes mellitus and hyperthermia) related congenital abnormalities.
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Prescription of any drug during pregnancy poses a risk to the unborn child.
“This goal is of fundamental importance because prescription of any drug during pregnancy poses a risk to the unborn child [5].”
From Reliability of rapid diagnostic test for diagnosing peripheral and placental malaria in an area of unstable malaria transmission in Eastern Sudan (2013) · cites this paper as [5]
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- Authors
- Bánhidy, F., Lowry, R. B., & Czeizel, A. E.
- Affiliations
- Semmelweis University (HU)
- University of Calgary (CA)
- Hereditary Disease Foundation (US)
- Venue
- International Journal of Medical Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2005
- Volume
- 2
- Issue
- 3
- Pages
- 100-106
- ISSN
- 1449-1907 (ISSN-L)
- PMC
- PMC1168874
- OpenAlex
- W2033933534
- Cited by
- 103
- References
- 51
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 12 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 6
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- International Journal of Medical Sciences (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- drug use in pregnancy, teratogenic drugs, congenital malformations, risk-benefit assessment, recall bias, case-control study, diabetes mellitus, hyperthermia, prenatal drug exposure
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