The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy
Open accessAbstract
Nanomedicine has attracted increasing attention in recent years, because it offers great promise to provide personalized diagnostics and therapy with improved treatment efficacy and specificity. In this study, we developed a gold nanostar (GNS) probe for multi-modality theranostics including surface-enhanced Raman scattering (SERS) detection, x-ray computed tomography (CT), two-photon luminescence (TPL) imaging, and photothermal therapy (PTT). We performed radiolabeling, as well as CT and optical imaging, to investigate the GNS probe's biodistribution and intratumoral uptake at both macroscopic and microscopic scales. We also characterized the performance of the GNS nanoprobe for in vitro photothermal heating and in vivo photothermal ablation of primary sarcomas in mice. The results showed that 30-nm GNS have higher tumor uptake, as well as deeper penetration into tumor interstitial space compared to 60-nm GNS. In addition, we found that a higher injection dose of GNS can increase the percentage of tumor uptake. We also demonstrated the GNS probe's superior photothermal conversion efficiency with a highly concentrated heating effect due to a tip-enhanced plasmonic effect. In vivo photothermal therapy with a near-infrared (NIR) laser under the maximum permissible exposure (MPE) led to ablation of aggressive tumors containing GNS, but had no effect in the absence of GNS. This multifunctional GNS probe has the potential to be used for in vivo biosensing, preoperative CT imaging, intraoperative detection with optical methods (SERS and TPL), as well as image-guided photothermal therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering
Nie, S., & Emory, S. R. (1997) · Science · doi:10.1126/science.275.5303.1102 · Cited by 10,238
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,955
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Delivering nanomedicine to solid tumors
Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,180
Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170
Surface‐Enhanced Raman Spectroscopy: Concepts and Chemical Applications
Schlücker, S. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201205748 · Cited by 2,417
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
Jackson, E. L., Willis, N., Mercer, K., Bronson, R. T., Crowley, D., Montoya, R., Jacks, T., & Tuveson, D. A. (2001) · Genes & Development · doi:10.1101/gad.943001 · Cited by 1,898
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
O'Neal, D. P., Hirsch, L. R., Halas, N. J., Payne, J. D., & West, J. L. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.02.004 · Cited by 1,849
Microscale Heat Transfer Transduced by Surface Plasmon Resonant Gold Nanoparticles
Roper, D. K., Ahn, W., & Hoepfner, M. (2007) · The Journal of Physical Chemistry C · doi:10.1021/jp064341w · Cited by 1,708
Nanoparticle-based theranostic agents
Xie, J., Lee, S., & Chen, X. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.009 · Cited by 1,422
Cited by
Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics
Zou, L., Wang, H., He, B., Zeng, L., Tan, T., Cao, H., He, X., Zhang, Z., Guo, S., & Li, Y. (2016) · Theranostics · doi:10.7150/thno.14988 · Cited by 915
A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer
Whitley, M. J., Cardona, D. M., Lazarides, A. L., Spasojevic, I., Ferrer, J. M., Cahill, J., Lee, C.-L., Snuderl, M., Blazer, D. G., Hwang, E. S., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0293 · Cited by 296
Recent Studies and Progress in the Intratumoral Administration of Nano-Sized Drug Delivery Systems
Yun, W. S., Kim, J., Lim, D.-K., Kim, D.-H., Jeon, S. I., & Kim, K. (2023) · Nanomaterials · doi:10.3390/nano13152225 · Cited by 76
Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy
Woźniak, M., Płoska, A., Siekierzycka, A., Dobrucki, L. W., Kalinowski, L., & Dobrucki, I. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052658 · Cited by 59
Plasmonic nanoplatforms: From surface‐enhanced Raman scattering sensing to biomedical applications
Cupil‐Garcia, V., Strobbia, P., Crawford, B. M., Wang, H., Ngo, H., Liu, Y., & Vo‐Dinh, T. (2021) · Journal of Raman Spectroscopy · doi:10.1002/jrs.6056 · Cited by 34
Self-citation
Metadata
- Authors
- Liu, Y., Ashton, J. R., Moding, E. J., Yuan, H., Register, J. K., Fales, A. M., Choi, J., Whitley, M. J., Zhao, X., Qi, Y., Ma, Y., Vaidyanathan, G., Zalutsky, M. R., Kirsch, D. G., Badea, C. T., & Vo-Dinh, T.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2015
- Volume
- 5
- Issue
- 9
- Pages
- 946-960
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2187797706
- Cited by
- 308
- References
- 67
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy. https://app.cochat.ai/papers/10.7150/thno.11974
- The paper
- Liu, Y., Ashton, J. R., Moding, E. J., Yuan, H., Register, J. K., Fales, A. M., Choi, J., Whitley, M. J., Zhao, X., Qi, Y., Ma, Y., Vaidyanathan, G., Zalutsky, M. R., Kirsch, D. G., Badea, C. T., & Vo-Dinh, T. (2015). A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy. Theranostics. https://doi.org/10.7150/thno.11974
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
