The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model
Open accessAbstract
Lewy bodies are considered as the main pathological characteristics of Parkinson's disease (PD).The major component of Lewy bodies is α-synuclein (α-syn).The use of gene therapy that targeting and effectively interfere with the expression of α-syn in neurons has received tremendous attention.In this study, we used magnetic Fe3O4 nanoparticles coated with oleic acid molecules as a nano-carrier.N-isopropylacrylamide derivative (NIPAm-AA) was photo-immobilized onto the oleic acid molecules, and shRNA (short hairpin RNA) was absorbed.The same method was used to absorb nerve growth factor (NGF) to NIPAm-AA to specifically promote neuronal uptake via NGF receptor-mediated endocytosis.Additionally, shRNA plasmid could be released into neurons because of the temperature and pH sensitivity of NIPAm-AA interference with α-syn synthesis.We investigated apoptosis in neurons with abrogated α-syn expression in vitro and in vivo.The results demonstrated that multifunctional superparamagnetic nanoparticles carrying shRNA for α-syn could provide effective repair in a PD model.
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Cites
Tai chi and postural stability in patients with Parkinson's disease
Li, F., Harmer, P., Fitzgerald, K., Eckstrom, E., Stock, R., Galver, J., Maddalozzo, G., & Batya, S. S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107911 · Cited by 890
Repression of α-synuclein expression and toxicity by microRNA-7
Junn, E., Lee, K.-W., Jeong, B. S., Chan, T. W., Im, J.-Y., & Mouradian, M. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906277106 · Cited by 655
Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies
Chauhan, V. P., Stylianopoulos, T., Boucher, Y., & Jain, R. K. (2011) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061010-114300 · Cited by 597
Oliveras-Salvá, M., Van der Perren, A., Casadei, N., Stroobants, S., Nuber, S., D’Hooge, R., Van den Haute, C., & Baekelandt, V. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-44 · Cited by 191
Cited by
Li, R., Li, D., Wu, C., Ye, L., Wu, Y., Yuan, Y., Yang, S., Xie, L., Mao, Y., Jiang, T., et al. (2020) · Theranostics · doi:10.7150/thno.40919 · Cited by 287
Yang, J., Luo, S., Zhang, J., Yu, T., Fu, Z., Zheng, Y., Xu, X., Liu, C., Fan, M., & Zhang, Z. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105218 · Cited by 152
Neurotheranostics as Personalized Medicines
Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J., Gorantla, S., Bronich, T. K., Edagwa, B., & Gendelman, H. E. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.011 · Cited by 124
Choudhury, S. P., Bano, S., Sen, S., Suchal, K., Kumar, S., Nikolajeff, F., Dey, S. K., & Sharma, V. (2022) · npj Parkinson's Disease · doi:10.1038/s41531-022-00324-9 · Cited by 52
Tomitaka, A., Vashist, A., Kolishetti, N., & Nair, M. (2023) · Nanoscale Advances · doi:10.1039/d3na00180f · Cited by 45
Metadata
- Authors
- Niu, S., Zhang, L.-K., Zhang, L., Zhuang, S., Zhan, X., Chen, W.-Y., Du, S., Yin, L., You, R., Li, C.-H., & Guan, Y.-Q.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2017
- Volume
- 7
- Issue
- 2
- Pages
- 344-356
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2566789527
- Cited by
- 172
- References
- 4
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Niu, S., Zhang, L.-K., Zhang, L., Zhuang, S., Zhan, X., Chen, W.-Y., Du, S., Yin, L., You, R., Li, C.-H., & Guan, Y.-Q. (2017). Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model. Theranostics. https://doi.org/10.7150/thno.16562
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
