The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy
Open accessAbstract
Multifunctional nanoparticles have been widely investigated for biomedical applications, such as imaging, therapy, and drug delivery.Especially, photoactive nanoparticles have received great attention as theranostic agents because of their heat-generating abilities after exposure to laser irradiation.However, photostability and safety issues have been the technical hurdles for further clinical applications.Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have strong absorption in the near-infrared region, high photostability, and excellent biodegradability.Optimized N-CNDs can be utilized not only as a new photoacoustic (PA) imaging agent but also as a superior photothermal therapy (PTT) agent in vivo because of their strong optical absorption at a specific wavelength.We used N-CNDs to perform in vivo/ex vivo noninvasive PA imaging of sentinel lymph nodes via local delivery and performed PTT for cancer ablation therapy.Finally, biodegradation and renal clearance were confirmed by performing whole-body PA monitoring and a degradation test.
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Cites
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Photoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Cited by
Xu, M., Qi, Y., Liu, G., Song, Y., Jiang, X., & Du, B. (2023) · ACS Nano · doi:10.1021/acsnano.3c05853 · Cited by 632
Carbon-based nanomaterials as an emerging platform for theranostics
Patel, K. D., Singh, R. K., & Kim, H.-W. (2019) · Materials Horizons · doi:10.1039/c8mh00966j · Cited by 555
Self-citationInorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Bao, X., Yuan, Y., Chen, J., Zhang, B., Li, D., Zhou, D., Jing, P., Xu, G., Wang, Y., Holá, K., et al. (2018) · Light: Science & Applications · doi:10.1038/s41377-018-0090-1 · Cited by 445
Mansuriya, B. D., & Altintas, Z. (2021) · Nanomaterials · doi:10.3390/nano11102525 · Cited by 438
Metadata
- Authors
- Lee, C., Kwon, W., Beack, S., Lee, D., Park, Y., Kim, H., Hahn, S. K., Rhee, S.-W., & Kim, C.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2016
- Volume
- 6
- Issue
- 12
- Pages
- 2196-2208
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2553521683
- Cited by
- 165
- References
- 2
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lee, C., Kwon, W., Beack, S., Lee, D., Park, Y., Kim, H., Hahn, S. K., Rhee, S.-W., & Kim, C. (2016). Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy. Theranostics. https://doi.org/10.7150/thno.16923
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