The DOI matches its Crossref record; 303 of the 303 references it cites were found in a registry or an index.
The role of lipid metabolic reprogramming in tumor microenvironment
Open accessAbstract
Metabolic reprogramming is one of the most important hallmarks of malignant tumors.Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and therapeutic response by remodeling the tumor microenvironment (TME).In the past few decades, immunotherapy has revolutionized the treatment landscape for advanced cancers.Lipid metabolic reprogramming plays pivotal role in regulating the immune microenvironment and response to cancer immunotherapy.Here, we systematically reviewed the characteristics, mechanism, and role of lipid metabolic reprogramming in tumor and immune cells in the TME, appraised the effects of various cell death modes (specifically ferroptosis) on lipid metabolism, and summarized the antitumor therapies targeting lipid metabolism.Overall, lipid metabolic reprogramming has profound effects on cancer immunotherapy by regulating the immune microenvironment; therefore, targeting lipid metabolic reprogramming may lead to the development of innovative clinical applications including sensitizing immunotherapy. Keywords: lipid metabolic reprogramming; tumor microenvironment; immunotherapy; therapeutic targetSimilarly, tumor-associated immune cells can selectively take up lipids according to the state of differentiation and activation but can also passively ingest some harmful lipids in the TME, such as ox-LDL [74].Table 1.Key enzymes of lipid metabolism and their expression in tumors.
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Cites
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“Finally, alterations in metabolism have long-term effects on the tumor and immune cells in the TME [21].”
Copper induces cell death by targeting lipoylated TCA cycle proteins
Tsvetkov, P., Coy, S., Petrova, B., Dreishpoon, M., Verma, A., Abdusamad, M., Rossen, J., Joesch-Cohen, L., Humeidi, R., Spangler, R. D., et al. (2022) · Science · doi:10.1126/science.abf0529 · Cited by 4,932
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
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Cited by
Gong, B., Li, C., Shi, Z., Wang, F., Dai, R., Chen, G., & Su, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1675552 · Cited by 36
Metadata
- Authors
- Yang, K., Wang, X., Song, C., He, Z., Wang, R., Xu, Y., Jiang, G., Wan, Y., Mei, J., & Mao, W.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2023
- Volume
- 13
- Issue
- 6
- Pages
- 1774-1808
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W4364323074
- Cited by
- 270
- References
- 303
- FWCI
- 26.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yang, K., Wang, X., Song, C., He, Z., Wang, R., Xu, Y., Jiang, G., Wan, Y., Mei, J., & Mao, W. (2023). The role of lipid metabolic reprogramming in tumor microenvironment. Theranostics. https://doi.org/10.7150/thno.82920
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