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Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation

Xin, Wenqiang, Pan, Yongli, Wei, Wei, Tatenhorst, Lars, Graf, Irina, Popa-Wagner, Aurel, Gerner, Stefan T, Huber, Sabine, Kilic, Ertugrul, Hermann, Dirk M, Bähr, Mathias, Huttner, Hagen B, Doeppner, Thorsten R·2023·Theranostics
DOI 10.7150/thno.84059PMC PMC10405850
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  1. [1]Fischer R Wajant H Kontermann R Pfizenmaier K Maier O Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor Glia 2014 62 2 272 83 24310780
  2. [2]Stoll G Jander S Schroeter M Inflammation and glial responses in ischemic brain lesions Prog Neurobiol 1998 56 2 149 71 9760699
  3. [3]Nayak AR Kashyap RS Kabra D Purohit HJ Taori GM Daginawala HF Time course of inflammatory cytokines in acute ischemic stroke patients and their relation to inter-alfa trypsin inhibitor heavy chain 4 and outcome Ann Indian Acad Neurol 2012 15 3 181 5 22919189 PMC3424794
  4. [4]Koyama Y Signaling molecules regulating phenotypic conversions of astrocytes and glial scar formation in damaged nerve tissues Neurochem Int 2014 78 35 42 25180676
  5. [5]Huang L Wu ZB Zhuge Q Zheng W Shao B Wang B Glial scar formation occurs in the human brain after ischemic stroke Int J Med Sci 2014 11 4 344 8 24578611 PMC3936028
  6. [6]Choudhury GR Ding S Reactive astrocytes and therapeutic potential in focal ischemic stroke Neurobiol Dis 2016 85 234 44 25982835 PMC4644522
  7. [7]Badaut J Fukuda AM Jullienne A Petry KG Aquaporin and brain diseases Biochim Biophys Acta 2014 1840 5 1554 65 24513456 PMC3960327
  8. [8]Ren Z Iliff JJ Yang L Yang J Chen X Chen MJ 'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation J Cereb Blood Flow Metab 2013 33 6 834 45 23443171 PMC3677112
  9. [9]Mogoanta L Ciurea M Pirici I Margaritescu C Simionescu C Ion DA Different dynamics of aquaporin 4 and glutamate transporter-1 distribution in the perineuronal and perivascular compartments during ischemic stroke Brain Pathol 2014 24 5 475 93 24571080 PMC8028976
  10. [10]Filchenko I Blochet C Buscemi L Price M Badaut J Hirt L Caveolin-1 Regulates Perivascular Aquaporin-4 Expression After Cerebral Ischemia Front Cell Dev Biol 2020 8 371 32523952 PMC7261922
  11. [11]Ji C Yu X Xu W Lenahan C Tu S Shao A The role of glymphatic system in the cerebral edema formation after ischemic stroke Exp Neurol 2021 340 113685 33676917
  12. [12]Sun C Lin L Yin L Hao X Tian J Zhang X Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia Front Immunol 2022 13 870029 35592320 PMC9110854
  13. [13]Yi T Gao P Hou M Lv H Huang M Gao S The mechanisms underlying the actions of Xuefu Zhuyu decoction pretreatment against neurological deficits after ischemic stroke in mice: The mediation of glymphatic function by aquaporin-4 and its anchoring proteins Front Pharmacol 2022 13 1053253 36582539 PMC9792381
  14. [14]Zhu DD Yang G Huang YL Zhang T Sui AR Li N AQP4-A25Q Point Mutation in Mice Depolymerizes Orthogonal Arrays of Particles and Decreases Polarized Expression of AQP4 Protein in Astrocytic Endfeet at the Blood-Brain Barrier J Neurosci 2022 42 43 8169 83 36100398 PMC9637001
  15. [15]Hermann DM Xin W Bähr M Giebel B Doeppner TR Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke Theranostics 2022 12 13 5776 802 35966580 PMC9373807
  16. [16]Lan X Han X Li Q Yang QW Wang J Modulators of microglial activation and polarization after intracerebral haemorrhage Nat Rev Neurol 2017 13 7 420 33 28524175 PMC5575938
  17. [17]Xiong XY Liu L Yang QW Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke Prog Neurobiol 2016 142 23 44 27166859
  18. [19]Liu Y Li Y-P Xiao L-M Chen L-K Zheng S-Y Zeng E-M Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis Lab Invest 2021 101 7 837 50 33875790
  19. [20]Tian Y Zhu P Liu S Jin Z Li D Zhao H IL-4-polarized BV2 microglia cells promote angiogenesis by secreting exosomes Adv Clin Exp Med 2019 28 4 421 30 30684318
  20. [21]Zhang D Cai G Liu K Zhuang Z Jia K Pei S Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1 Aging (Albany NY) 2021 13 3 4079 33461167 PMC7906161
  21. [22]Zhang L Wei W Ai X Kilic E Hermann DM Venkataramani V Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway Cell Death Dis 2021 12 11 1068 34753919 PMC8578653
  22. [23]Lian H Roy E Zheng H Protocol for primary microglial culture preparation Bio-protocol 2016 6 21 e1989 e 29104890 PMC5669279
  23. [25]Kuang Y Zheng X Zhang L Ai X Venkataramani V Kilic E Adipose-derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR-25 J Extracell Vesicles 2020 10 1 e12024 33304476 PMC7710129
  24. [26]Hung CC Lin CH Chang H Wang CY Lin SH Hsu PC Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity J Neurosci 2016 36 6 2027 43 26865625 PMC6602016
  25. [27]Zhang F Zhang JG Yang W Xu P Xiao YL Zhang HT 6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation Biomed Pharmacother 2018 107 1523 9 30257370
  26. [28]Lin A Liu J Gong P Chen Y Zhang H Zhang Y Serum amyloid A inhibits astrocyte migration via activating p38 MAPK J Neuroinflammation 2020 17 1 254 32861245 PMC7456509
  27. [30]Iliff JJ Chen MJ Plog BA Zeppenfeld DM Soltero M Yang L Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury J Neurosci 2014 34 49 16180 93 25471560 PMC4252540
  28. [31]Su Y Fan W Ma Z Wen X Wang W Wu Q Taurine improves functional and histological outcomes and reduces inflammation in traumatic brain injury Neuroscience 2014 266 56 65 24530657
  29. [32]Gao C Qian Y Huang J Wang D Su W Wang P A three-day consecutive fingolimod administration improves neurological functions and modulates multiple immune responses of CCI mice Mol Neurobiol 2017 54 10 8348 60 27924525
  30. [33]Balkaya M Kröber JM Rex A Endres M Assessing post-stroke behavior in mouse models of focal ischemia J Cereb Blood Flow Metab 2013 33 3 330 8 23232947 PMC3587814
  31. [34]Carter RJ Lione LA Humby T Mangiarini L Mahal A Bates GP Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation J Neurosci 1999 19 8 3248 57 10191337 PMC6782264
  32. [35]Théry C Witwer KW Aikawa E Alcaraz MJ Anderson JD Andriantsitohaina R Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines J Extracell Vesicles 2018 7 1 1535750 30637094 PMC6322352
  33. [36]Hou C Li J Wang B Liu Q Zhao Y Zhang H Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage Front Neurol 2022 13 924080 35847203 PMC9283644
  34. [37]Benfenati V Nicchia GP Svelto M Rapisarda C Frigeri A Ferroni S Functional down-regulation of volume-regulated anion channels in AQP4 knockdown cultured rat cortical astrocytes J Neurochem 2007 100 1 87 104 17064359
  35. [38]Clasadonte J Dong J Hines DJ Haydon PG Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy Proc Natl Acad Sci U S A 2013 110 43 17540 5 24101472 PMC3808607
  36. [39]Manley GT Binder DK Papadopoulos MC Verkman AS New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice Neuroscience 2004 129 4 983 91 15561413
  37. [40]Clément T Rodriguez-Grande B Badaut J Aquaporins in brain edema J Neurosci Res 2020 98 1 9 18 30430614
  38. [41]Hou C Liu Q Zhang H Wang W Wang B Cui X Nimodipine Attenuates Early Brain Injury by Protecting the Glymphatic System After Subarachnoid Hemorrhage in Mice Neurochem Res 2022 47 3 701 12 34792752
  39. [42]Pekny M Pekna M Astrocyte reactivity and reactive astrogliosis: costs and benefits Physiol Rev 2014 94 4 1077 98 25287860
  40. [44]Cregg JM DePaul MA Filous AR Lang BT Tran A Silver J Functional regeneration beyond the glial scar Exp Neurol 2014 253 197 207 24424280 PMC3951813
  41. [45]Zhang R Wu Y Xie F Zhong Y Wang Y Xu M RGMa mediates reactive astrogliosis and glial scar formation through TGFβ1/Smad2/3 signaling after stroke Cell Death Differ 2018 25 8 1503 16 29396549 PMC6113216
  42. [46]Zhong K Wang RX Qian XD Yu P Zhu XY Zhang Q Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats Biomed Pharmacother 2020 126 110041 32113053
  43. [47]Song Y Li Z He T Qu M Jiang L Li W M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124 Theranostics 2019 9 10 2910 23 31244932 PMC6568171
  44. [48]Gao M Lu W Shu Y Yang Z Sun S Xu J Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model CNS Neurosci Ther 2020 26 12 1288 302 32790044 PMC7702237
  45. [51]Holter KE Kehlet B Devor A Sejnowski TJ Dale AM Omholt SW Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow Proc Natl Acad Sci U S A 2017 114 37 9894 9 28847942 PMC5604020
  46. [52]Mestre H Hablitz LM Xavier AL Feng W Zou W Pu T Aquaporin-4-dependent glymphatic solute transport in the rodent brain Elife 2018 7 e40070 30561329 PMC6307855
  47. [53]Zeppenfeld DM Simon M Haswell JD D'Abreo D Murchison C Quinn JF Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains JAMA Neurol 2017 74 1 91 9 27893874
  48. [54]Zhu A Lin Y Hu X Lin Z Lin Y Xie Q Treadmill exercise decreases cerebral edema in rats with local cerebral infarction by modulating AQP4 polar expression through the caveolin-1/TRPV4 signaling pathway Brain Res Bull 2022 188 155 68 35961528
  49. [55]Weber RZ Grönnert L Mulders G Maurer MA Tackenberg C Schwab ME Characterization of the Blood Brain Barrier Disruption in the Photothrombotic Stroke Model Front Physiol 2020 11 586226 33262704 PMC7688466
  50. [56]Liu H Qiu G Zhuo F Yu W Sun S Li F Lost Polarization of Aquaporin4 and Dystroglycan in the Core Lesion after Traumatic Brain Injury Suggests Functional Divergence in Evolution Biomed Res Int 2015 2015 471631 26583111 PMC4637040
  51. [57]He XF Li G Li LL Li MY Liang FY Chen X Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model Mol Brain 2020 13 1 135 33028376 PMC7542754
  52. [58]Smith AJ Duan T Verkman AS Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure Acta Neuropathol Commun 2019 7 1 74 31068220 PMC6506955
  53. [59]Liddelow SA Barres BA Reactive Astrocytes: Production, Function, and Therapeutic Potential Immunity 2017 46 6 957 67 28636962
  54. [60]Dai W Yan J Chen G Hu G Zhou X Zeng X AQP4-knockout alleviates the lipopolysaccharide-induced inflammatory response in astrocytes via SPHK1/MAPK/AKT signaling Int J Mol Med 2018 42 3 1716 22 29956748
  55. [61]Sun H Liang R Yang B Zhou Y Liu M Fang F Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson's disease Neuroscience 2016 317 65 75 26774050
  56. [62]Manley GT Fujimura M Ma T Noshita N Filiz F Bollen AW Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke Nat Med 2000 6 2 159 63 10655103
  57. [63]Xin WQ Wei W Pan YL Cui BL Yang XY Bähr M Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia World J Stem Cells 2021 13 8 1030 48 34567423 PMC8422926
  58. [64]Han B Jiang W Cui P Zheng K Dang C Wang J Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation Genome Med 2021 13 1 47 33771213 PMC8004413
  59. [65]Boland B Yu WH Corti O Mollereau B Henriques A Bezard E Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing Nat Rev Drug Discov 2018 17 9 660 88 30116051 PMC6456907
  60. [66]Mader S Brimberg L Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease Cells 2019 8(2) PMC6406241 30691235
  61. [67]Mogensen FL Delle C Nedergaard M The Glymphatic System (En)during Inflammation Int J Mol Sci 2021 22(14) PMC8305763 34299111
  62. [68]Li Z Song Y He T Wen R Li Y Chen T M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice Theranostics 2021 11 3 1232 33391532 PMC7738903
  63. [69]Wang W Huang XR Li AG Liu F Li J-H Truong LD Signaling mechanism of TGF-β1 in prevention of renal inflammation: role of Smad7 J Am Soc Nephrol 2005 16 5 1371 83 15788474
  64. [70]Kulkarni AB Ward JM Yaswen L Mackall CL Bauer SR Huh C-G Transforming growth factor-beta 1 null mice. An animal model for inflammatory disorders Am J Pathol 1995 146 1 264 7856732 PMC1870760
  65. [71]Yaswen L Kulkarni AB Fredrickson T Mittleman B Schiffman R Payne S Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse Blood 1996 87 4 1439 45 8608234
  66. [72]Islam A Choudhury ME Kigami Y Utsunomiya R Matsumoto S Watanabe H Sustained anti-inflammatory effects of TGF-β1 on microglia/macrophages Biochim Biophys Acta, Mol Basis Dis 2018 1864 3 721 34 29269050
  67. [73]Liu X Zhang M Liu H Zhu R He H Zhou Y Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes Exp Neurol 2021 341 113700 33741350
  68. [74]Gregorius J Wang C Stambouli O Hussner T Qi Y Tertel T Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice Basic Res Cardiol 2021 116 1 40 34105014 PMC8187185

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Metadata

Authors
Xin, W., Pan, Y., Wei, W., Tatenhorst, L., Graf, I., Popa-Wagner, A., Gerner, S. T., Huber, S., Kilic, E., Hermann, D. M., Bähr, M., Huttner, H. B., & Doeppner, T. R.
Venue
Theranostics
Publisher
Ivyspring International Publisher
Published
2023
Volume
13
Issue
12
Pages
4197-4216
ISSN
1838-7640
DOI
10.7150/thno.84059
PMC
PMC10405850
Cited by
77
References
6
Language
en

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