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GELDANAMYCIN, A NEW ANTIBIOTIC
Open accessAbstract
A new crystalline antimicrobial compound, geldanamycin, has been discovered in the culture nitrates of Streptomyces hygroscopicus var. geldanus var. nova. Geldanamycin is moderately active in vitro against protozoa, bacteria and fungi. It is also active against L-1210 and KB cells growing in culture and against the parasite Syphacia ohlevata, in vivo. The fermentation, assay, chromatography and isolation as well as its biological and chemical properties were investigated. On the basis of its physical and chemical properties, geldanamycin is a complex molecule consisting of an unsaturated moiety attached to a quinone.
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Cites
Mass spectrometry of organic compounds
Budzikiewicz, H., Djerassi, C., & Williams, D. H. (1967) · Medical Entomology and Zoology · Cited by 934
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Stebbins, C. E., Russo, A. A., Schneider, C., Rosen, N., Hartl, F. U., & Pavletich, N. P. (1997) · Cell · doi:10.1016/s0092-8674(00)80203-2 · Cited by 1,364
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Metadata
- Authors
- DEBOER, C., MEULMAN, P. A., WNUK, R. J., & PETERSON, D. H.
- Venue
- The Journal of Antibiotics
- Published
- 1970
- Volume
- 23
- Issue
- 9
- Pages
- 442-447
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2068650460
- Cited by
- 466
- References
- 1
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- DEBOER, C., MEULMAN, P. A., WNUK, R. J., & PETERSON, D. H. (1970). GELDANAMYCIN, A NEW ANTIBIOTIC. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.23.442
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
