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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.
Open accessAbstract
Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183 approximately to 185 degrees C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin.
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Cited by
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Metadata
- Authors
- SEHGAL, S. N., BAKER, H., & VÉZINA, C.
- Venue
- The Journal of Antibiotics
- Published
- 1975
- Volume
- 28
- Issue
- 10
- Pages
- 727-732
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2626632314
- Cited by
- 947
- References
- 0
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- SEHGAL, S. N., BAKER, H., & VÉZINA, C. (1975). Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.28.727
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
