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A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.
Open accessAbstract
AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed.
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Cited by
Kase, H., Iwahashi, K., Nakanishi, S., Matsuda, Y., Yamada, K., Takahashi, M., Murakata, C., Sato, A., & Kaneko, M. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90293-2 · Cited by 938
Antitumor compounds from marine actinomycetes
Olano, C., Méndez, C., & Salas, J. A. (2009) · Marine Drugs · doi:10.3390/md7020210 · Cited by 330
LaFayette, S. L., Collins, C., Zaas, A. K., Schell, W. A., Betancourt-Quiroz, M., Gunatilaka, A. A. L., Perfect, J. R., & Cowen, L. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001069 · Cited by 329
ReDU: a framework to find and reanalyze public mass spectrometry data
Jarmusch, A. K., Wang, M., Aceves, C. M., Advani, R. S., Aguirre, S., Aksenov, A. A., Aleti, G., Aron, A. T., Bauermeister, A., Bolleddu, S., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-0916-7 · Cited by 152
Mechanistic Insight into Neurotoxicity Induced by Developmental Insults
Tamm, C., & Ceccatelli, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.087 · Cited by 28
Metadata
- Authors
- OMURA, S., IWAI, Y., HIRANO, A., NAKAGAWA, A., AWAYA, J., TSUCHIYA, H., TAKAHASHI, Y., & ASUMA, R.
- Venue
- The Journal of Antibiotics
- Published
- 1977
- Volume
- 30
- Issue
- 4
- Pages
- 275-282
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2167944112
- Cited by
- 674
- References
- 0
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization. https://app.cochat.ai/papers/10.7164/antibiotics.30.275
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- OMURA, S., IWAI, Y., HIRANO, A., NAKAGAWA, A., AWAYA, J., TSUCHIYA, H., TAKAHASHI, Y., & ASUMA, R. (1977). A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.30.275
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