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Metabolites from symbiotic bacteriaThis review is dedicated to Professor Axel Zeeck on the occasion of his 65th birthday.

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Taxonomy, Fermentation, Isolation and Biological Activities.

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The prodigiosins, proapoptotic drugs with anticancer properties

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The Ammosamides: Structures of Cell Cycle Modulators from a Marine‐Derived Streptomyces Species

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Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937

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Deciphering the Biosynthesis Pathway of the Antitumor Thiocoraline from a Marine Actinomycete and Its Expression in Two Streptomyces Species

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Diversity and biogeography of marine actinobacteria

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New Cytotoxic Salinosporamides from the Marine Actinomycete Salinispora tropica

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Cyanosporasides A and B, Chloro- and Cyano-cyclopenta[ a ]indene Glycosides from the Marine Actinomycete “ Salinispora pacifica ”

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Microbial technologies for the discovery of novel bioactive metabolites

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Antibiotic Terpenoid Chloro-Dihydroquinones from a New Marine Actinomycete

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A Gene Cluster from a Marine Streptomyces Encoding the Biosynthesis of the Aromatic Spiroketal Polyketide Griseorhodin A

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Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine streptomycete and their absolute stereochemistry

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Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

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Chandrananimycins A-C: Production of Novel Anticancer Antibiotics from a Marine Actinomadura sp. Isolate M048 by Variation of Medium Composition and Growth Conditions

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Mechercharmycins A and B, Cytotoxic Substances from Marine-derived Thermoactinomyces sp. YM3-251

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Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces nodosus

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Estimating and comparing the diversity of marine actinobacteria

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Piperazimycins: Cytotoxic Hexadepsipeptides from a Marine-Derived Bacterium of the Genus Streptomyces

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Deciphering the late steps in the biosynthesis of the anti‐tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

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Lucentamycins A−D, Cytotoxic Peptides from the Marine-Derived Actinomycete <i>Nocardiopsis </i><i>lucentensis</i>

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Arenamides A−C, Cytotoxic NFκB Inhibitors from the Marine Actinomycete Salinispora arenicola

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Marineosins A and B, Cytotoxic Spiroaminals from a Marine-Derived Actinomycete

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Saliniketals A and B, Bicyclic Polyketides from the Marine Actinomycete Salinispora arenicola

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Chinikomycins A and B: Isolation, Structure Elucidation, and Biological Activity of Novel Antibiotics from a Marine Streptomyces sp. Isolate M045,1

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Detection of antitumor and antimicrobial activities in marine organism associated actinomycetes isolated from the Taiwan Strait, China

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Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

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Studies on marine microorganisms. IV. A new antibiotic SS-228 Y produced by Chainia isolated from shallow sea mud.

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Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

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Himalomycin A and B: Isolation and Structure Elucidation of New Fridamycin Type Antibiotics from a Marine Streptomyces Isolate

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Host-microbe interaction: bacteria

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Mode of action of thiocoraline, a natural marine compound with anti-tumour activity

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Arenicolides A−C, 26-Membered Ring Macrolides from the Marine Actinomycete Salinispora arenicola

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Neomarinone, and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales)

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Actinobacterial diversity from marine sediments collected in Mexico

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NF-κB as a target for cancer therapy

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Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies

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Salinipyrones and Pacificanones, Mixed-Precursor Polyketides from the Marine Actinomycete Salinispora pacifica

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Engineering actinomycetes for biosynthesis of macrolactone polyketides

Dhakal, D., Sohng, J. K., & Pandey, R. P. (2019) · Microbial Cell Factories · doi:10.1186/s12934-019-1184-z · Cited by 36 · see citing works

Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP

Elmallah, M. I. Y., Cogo, S. C., Constantinescu, A. A., Elífio-Esposito, S., Abdelfattah, M. S., & Micheau, O. (2020) · Cells · doi:10.3390/cells9081760 · Cited by 36 · see citing works

Cloning, Characterization and Heterologous Expression of the Indolocarbazole Biosynthetic Gene Cluster from Marine-Derived Streptomyces sanyensis FMA

Li, T., Du, Y., Cui, Q., Zhang, J., Zhu, W., Hong, K., & Li, W. (2013) · Marine Drugs · doi:10.3390/md11020466 · Cited by 35 · see citing works

Nocapyrones H–J, 3,6-Disubstituted α-Pyrones from the Marine Actinomycete Nocardiopsis sp. KMF-001

Kim, M. C., Kwon, O. W., Park, J., Kim, S. Y., & Kwon, H. C. (2013) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c12-00956 · Cited by 35 · see citing works

In vitro Anticancer Property of Yellow Pigment fromStreptomyces griseoaurantiacus JUACT 01

Prashanthi, K., Suryan, S., & Nadumane, V. K. (2015) · Brazilian Archives of Biology and Technology · doi:10.1590/s1516-89132015060271 · Cited by 34 · see citing works

A Hybrid NRPS-PKS Gene Cluster Related to the Bleomycin Family of Antitumor Antibiotics in Alteromonas macleodii Strains

Mizuno, C. M., Kimes, N. E., López‐Pérez, M., Ausó, E., Rodríguez‐Valera, F., & Ghai, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076021 · Cited by 34 · see citing works

Streptomyces triticisoli sp. nov., a novel actinomycete isolated from rhizosphere soil of wheat (Triticum aestivum L.)

Tian, Y., Han, C., Zhao, J., Shi, H., Hu, J., Jiang, S., Han, X., Wang, X., & Xiang, W. (2018) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.002993 · Cited by 33 · see citing works

Anti-cancer and antimicrobial potential of five soil Streptomycetes : a metabolomics-based study

Osama, N., Bakeer, W., Raslan, M., Soliman, H. A., Abdelmohsen, U. R., & Sebak, M. (2022) · Royal Society Open Science · doi:10.1098/rsos.211509 · Cited by 33 · see citing works

A Chemoinformatics Approach to the Discovery of Lead-Like Molecules from Marine and Microbial Sources En Route to Antitumor and Antibiotic Drugs

Pereira, F., Latino, D. A. R. S., & Gaudêncio, S. P. (2014) · Marine Drugs · doi:10.3390/md12020757 · Cited by 32 · see citing works

Screening the Egyptian desert actinomycetes as candidates for new antimicrobial compounds and identification of a new desert Streptomyces strain

Hozzein, W. N., Rabie, W., & Ali, M. I. A. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · Cited by 31 · see citing works

Baikalomycins A-C, New Aquayamycin-Type Angucyclines Isolated from Lake Baikal Derived Streptomyces sp. IB201691-2A

Voitsekhovskaia, I., Paulus, C., Dahlem, C., Rebets, Y. V., Nadmid, S., Zapp, J., Axenov‐Gribanov, D. V., Rückert, C., Timofeyev, M. A., Kalinowski, J., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8050680 · Cited by 31 · see citing works

Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells

Shah, A. M., Wani, A., Qazi, P. H., Shakeel-u-Rehman, Mushtaq, S., Ali, S. A., Hussain, A., Shah, A., Qazi, A. K., Makhdoomi, U. S., et al. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.06.032 · Cited by 30 · see citing works

Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

García‐Salcedo, R., Olano, C., Gómez, C., Fernández, R., Braña, A. F., Méndez, C., de la Calle, F., & Salas, J. A. (2016) · Microbial Cell Factories · doi:10.1186/s12934-016-0443-5 · Cited by 29 · see citing works

Pharmacologically prospective antibiotic agents and their sources: A marine microbial perspective

Bhatnagar, I., & Kim, S. (2012) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2012.08.016 · Cited by 29 · see citing works

Bioprospection of marine actinomycetes: recent advances, challenges and future perspectives

Sharma, S., Fulke, A. B., & Chaubey, A. (2019) · Acta Oceanologica Sinica · doi:10.1007/s13131-018-1340-z · Cited by 29 · see citing works

Novel marine Nocardiopsis dassonvillei-DS013 mediated silver nanoparticles characterization and its bactericidal potential against clinical isolates

Dhanaraj, S., Somanathan, T., John, H. A., Pandian, S., Salmen, S. H., Chinnathambi, A., & Alharbi, S. A. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.01.003 · Cited by 28 · see citing works

Isolation, phylogenetic analysis and antimicrobial activity of halophilic actinomycetes from different saline environments located near Çorum province

Tatar, D. (2020) · Biologia · doi:10.2478/s11756-020-00612-w · Cited by 28 · see citing works

Antibacterial and cytotoxic potency of thermophilic Streptomyces werraensis MI-S.24-3 isolated from an Egyptian extreme environment

Mohamed, H., Hassane, A. M. A., Rawway, M., El-Sayed, M. H., Gomaa, A. E.-R. F., Abdul-Raouf, U. M., Shah, A. M., Abdel-Motaal, H., & Song, Y. (2021) · Archives of Microbiology · doi:10.1007/s00203-021-02487-0 · Cited by 28 · see citing works

Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis

Álvarez, R., & de Lera, Á. R. (2020) · Natural Product Reports · doi:10.1039/d0np00050g · Cited by 28 · see citing works

Marine Sponge Derived Actinomycetes and Their Anticancer Compounds

Sivakumar, K., Manivasagan, P., & Kim, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_34 · Cited by 2 · see citing works

Novel anticancer compounds from marine actinomycetes : A Review

Devi, C. S. (2011) · Cited by 23 · see citing works

Advance in Researches of Antitumor Bioactive Substances from Marine Actinomycetes

Sheng-mei, H. (2008) · Anhui nongye kexue

The Current Status of Novel Anticancer Drugs from Marine Actinobacteria

Manivasagan, P., & Kim, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_12

Actinomycetes: A Source of Anticancer Metabolites

Kabilan, M., Duraipandiyan, V., Paul, P., & Amalraj, J. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673309904240911080042 · Cited by 3 · see citing works