The DOI matches its Crossref record.
Antimicrobial action of .EPSILON.-poly-L-lysine.
Open accessAbstract
The antimicrobial spectrum of epsilon-poly-L-lysine (n = 25-30, epsilon-PL) was investigated by comparison with alpha-poly-L-lysine (n = 50, alpha-PL). epsilon-PL showed antimicrobial activity against Gram-positive and -negative bacteria at concentrations of 1-8 micrograms/ml. alpha-PL was less active than epsilon-PL. A chain length of at least 10 L-lysine monomers was found to be optimum for antimicrobial activity. Chemical modification of the amino groups of epsilon-PL lowered its antibacterial activity. Studies on the mode of action of epsilon-PL suggest that absorption of epsilon-PL to the bacterial cell surface plays an important role in its antibacterial activity.
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Citations
Cited by
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Wang, R., Li, J., Chen, W., Xu, T., Yun, S., Xu, Z., Xu, Z., Sato, T., Chi, B., & Xu, H. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201604894 · Cited by 471
Effect of Cell-Photosensitizer Binding and Cell Density on Microbial Photoinactivation
Demidova, T. N., & Hamblin, M. R. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.6.2329-2335.2005 · Cited by 432
Inherent Antibacterial Activity of a Peptide-Based β-Hairpin Hydrogel
Salick, D. A., Kretsinger, J. K., Pochan, D. J., & Schneider, J. P. (2007) · Journal of the American Chemical Society · doi:10.1021/ja076300z · Cited by 351
Metadata
- Authors
- SHIMA, S., MATSUOKA, H., IWAMOTO, T., & SAKAI, H.
- Venue
- The Journal of Antibiotics
- Published
- 1984
- Volume
- 37
- Issue
- 11
- Pages
- 1449-1455
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2035248785
- Cited by
- 463
- References
- 0
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- SHIMA, S., MATSUOKA, H., IWAMOTO, T., & SAKAI, H. (1984). Antimicrobial action of .EPSILON.-poly-L-lysine. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.37.1449
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