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Search for microbial insect growth regulators. II Allosamidin, a novel insect chitinase inhibitor.
Open accessAbstract
Allosamidin, a novel insect chitinase inhibitor, was isolated from the mycelium of Streptomyces sp.It showed strong inhibitory activity against the chitinases of the silkworm, Bombyx mori, in vitro, and also insecticidal activity by preventing its ecdysis in vivo, Chitin is a polymer of /3-1 ,4 linked iV-acetyl-D-glucosamine, whose natural occurrence is specialized and which is a main component of cuticle in insects.Its turnover is regulated mainly by two enzymes, chitin synthase for its synthesis and chitinase for its degradation, and it plays an important part in ecdysis.Therefore it has been thought that inhibitors of these enzymes should be good leads for
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Citations
Cited by
Chitin metabolism in insects: structure, function and regulation of chitin synthases and chitinases
Merzendorfer, H., & Zimoch, L. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00709 · Cited by 1,250
Biotechnological aspects of chitinolytic enzymes: a review
Dahiya, N., Tewari, R., & Hoondal, G. S. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0183-7 · Cited by 544
What's new in chitinase research?
Flach, J., Pilet, P. E., & Jollès, P. (1992) · Experientia · doi:10.1007/bf02124285 · Cited by 349
Compounds active against cell walls of medically important fungi
Hector, R. F. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.1.1 · Cited by 242
Chitinases: in agriculture and human healthcare
Nagpure, A., Choudhary, B., & Gupta, R. K. (2014) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2013.790874 · Cited by 145
Metadata
- Authors
- SAKUDA, S., ISOGAI, A., MATSUMOTO, S., & SUZUKI, A.
- Venue
- The Journal of Antibiotics
- Published
- 1987
- Volume
- 40
- Issue
- 3
- Pages
- 296-300
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2326670661
- Cited by
- 228
- References
- 0
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Search for microbial insect growth regulators. II Allosamidin, a novel insect chitinase inhibitor. https://app.cochat.ai/papers/10.7164/antibiotics.40.296
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- SAKUDA, S., ISOGAI, A., MATSUMOTO, S., & SUZUKI, A. (1987). Search for microbial insect growth regulators. II Allosamidin, a novel insect chitinase inhibitor. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.40.296
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.