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The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
Open accessAbstract
During the screening of fungi for inhibitors of squalene synthase, Phomasp.C2932 was found to produce three structurally related novel inhibitors.These compounds,designated the squalestatins, exhibited potent activity against both mammalian (rat liver) and fungal {Candida albicans) squalene synthase.Furthermore, they also had broad spectrum in vitro antifungal activity.High serum cholesterol levels have been established as an important risk factor for atherosclerosis, and cholesterol lowering regimens have been shown to decrease the incidence of coronary heart disease morbidity and mortality1'2).In the search for agents which may lower cholesterol levels,
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Cites
Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
Cited by
Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis
Nicolaou, K. C., Montagnon, T., & Snyder, S. A. (2003) · Chemical Communications · doi:10.1039/b209440c · Cited by 614
Antifungal agents: chemotherapeutic targets and immunologic strategies
Georgopapadakou, N. H., & Walsh, T. J. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.2.279 · Cited by 498
Groll, A. H., Piscitelli, S. C., & Walsh, T. J. (1998) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60129-5 · Cited by 377
Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules
Chooi, Y.-H., & Tang, Y. (2012) · The Journal of Organic Chemistry · doi:10.1021/jo301592k · Cited by 271
Metadata
- Authors
- DAWSON, M. J., FARTHING, J. E., MARSHALL, P. S., MIDDLETON, R. F., O''NEILL, M. J., SHUTTLEWORTH, A., STYLLI, C., TAIT, R. M., TAYLOR, P. M., WILDMAN, H. G., BUSS, A. D., LANGLEY, D., & HAYES, M. V.
- Venue
- The Journal of Antibiotics
- Published
- 1992
- Volume
- 45
- Issue
- 5
- Pages
- 639-647
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2330206990
- Cited by
- 183
- References
- 1
- FWCI
- 20.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- DAWSON, M. J., FARTHING, J. E., MARSHALL, P. S., MIDDLETON, R. F., O''NEILL, M. J., SHUTTLEWORTH, A., STYLLI, C., TAIT, R. M., TAYLOR, P. M., WILDMAN, H. G., BUSS, A. D., LANGLEY, D., & HAYES, M. V. (1992). The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.45.639
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
