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Epothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria). Production, Physico-chemical and Biological Properties.
Open accessAbstract
An antifungal activity against Mucor hiemalis was detected in the culture broth of Sorangium cellulosum (Myxococcales) strain So ce90. The activity was excreted into the supernatant during the log and early stationary phase. When the adsorber resin XAD-16 was added to the culture, the active metabolites were quantitatively bound to the resin. The epothilons showed a high cytotoxicity for animal cells and mimic the biological effects of taxol (BOLLAG et al., Cancer Res. 55: 2325 approximately 2333, 1995).
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Cited by
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The modification of natural products for medical use
Guo, Z. (2017) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.06.003 · Cited by 328
Myxobacterial secondary metabolites: bioactivities and modes-of-action
Weissman, K. J., & Müller, R. (2010) · Natural Product Reports · doi:10.1039/c001260m · Cited by 310
Kellogg, E. H., Hejab, N. M. A., Howes, S., Northcote, P., Miller, J. H., Díaz, J. F., Downing, K. H., & Nogales, E. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.01.001 · Cited by 234
Small molecule modulators of protein-protein interactions: selected case studies
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Metadata
- Authors
- GERTH, K., BEDORF, N., HÖFLE, G., IRSCHIK, H., & REICHENBACH, H.
- Venue
- The Journal of Antibiotics
- Published
- 1996
- Volume
- 49
- Issue
- 6
- Pages
- 560-563
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W1984050613
- Cited by
- 631
- References
- 0
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Epothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria). Production, Physico-chemical and Biological Properties. https://app.cochat.ai/papers/10.7164/antibiotics.49.560
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- GERTH, K., BEDORF, N., HÖFLE, G., IRSCHIK, H., & REICHENBACH, H. (1996). Epothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria). Production, Physico-chemical and Biological Properties. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.49.560
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
