Small molecule modulators of protein-protein interactions: selected case studies
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ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSmall Molecule Modulators of Protein–Protein Interactions: Selected Case StudiesMadhu Aeluri, Srinivas Chamakuri, Bhanudas Dasari, Shiva Krishna Reddy Guduru, Ravikumar Jimmidi, Srinivas Jogula, and Prabhat Arya*View Author Information Dr. Reddy's Institute of Life Sciences (DRILS), University of Hyderabad Campus Gachibowli, Hyderabad 500046, India*Phone: (+91) (40) 6657 1500. E mail: [email protected]Cite this: Chem. Rev. 2014, 114, 9, 4640–4694Publication Date (Web):March 27, 2014Publication History Received25 July 2013Published online27 March 2014Published inissue 14 May 2014https://pubs.acs.org/doi/10.1021/cr4004049https://doi.org/10.1021/cr4004049review-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views6379Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Apoptosis,Cells,Inhibitors,Peptides and proteins,Small molecules Get e-Alerts
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Analysis of crystal structure of MDM2-p53 complex showed interaction primarily mediated by three hydrophobic residues Phe19, Trp23, Leu26 of p53 peptide and a small deep hydrophobic cleft in MDM2.
“Analysis of the crystal structure of the MDM2-p53 complex showed that the interaction between MDM2 and its transcriptional factor p53 was primarily mediated by three hydrophobic residues, namely Phe19, Trp23, and Leu26 of a p53 peptide and a small deep hydrophobic cleft in MDM2 [38].”
From Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells (2017) · cites this paper as [38]
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- Authors
- Aeluri, M., Chamakuri, S., Dasari, B., Guduru, S. K. R., Jimmidi, R., Jogula, S., & Arya, P.
- Affiliations
- University of Hyderabad (IN)
- Corresponding author
- Arya, Prabhat
- ORCID
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-03-27
- Volume
- 114
- Issue
- 9
- Pages
- 4640-4694
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2312443521
- Cited by
- 79
- References
- 525
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 12 · 2017: 7 · 2016: 16 · 2015: 15 · 2014: 3
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Keywords
- small molecule modulators, protein-protein interaction, small molecule inhibitors, peptides and proteins
- MeSH terms
- Animals, Humans, Protein Binding, Proteins, Tubulin, HSP90 Heat-Shock Proteins, Proto-Oncogene Proteins c-bcl-2, 14-3-3 Proteins, Apoptosis Regulatory Proteins, Small Molecule Libraries
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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