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Tubulysins, New Cytostatic Peptides from Myxobacteria Acting on Microtubuli. Production, Isolation, Physico-chemical and Biological Properties.
Open accessAbstract
New cytostatic compounds, tubulysins, were isolated from the culture broth of strains of the myxobacteria Archangium gephyra and Angiococcus disciformis. The compounds are peptides partly consisting of unusual amino acids and are distantly related to the dolastatins. The tubulysins were not active against bacteria and only little against fungi, but showed high cytostatic activity against mammalian cell lines with IC50 values in the picomolar range. An incubation with 50 ng/ml tubulysin A led to a complete disappearance of the microtubuli network of the cells within 24 hours. The more active tubulysin D induced multipolar spindles: At 0.5 ng/ml all mitotic cells showed more than four spindle poles.
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Cited by
Recent applications of multicomponent reactions in medicinal chemistry
Slobbe, P., Ruijter, E., & Orru, R. V. A. (2012) · MedChemComm · doi:10.1039/c2md20089a · Cited by 484
Tan, M. L., Choong, P. F. M., & Dass, C. R. (2010) · Peptides · doi:10.1016/j.peptides.2009.10.002 · Cited by 350
Myxobacterial secondary metabolites: bioactivities and modes-of-action
Weissman, K. J., & Müller, R. (2010) · Natural Product Reports · doi:10.1039/c001260m · Cited by 310
Metadata
- Authors
- SASSE, F., SIEINMETZ, H., HEIL, J., HÖFLE, G., & REICHENBACH, H.
- Venue
- The Journal of Antibiotics
- Published
- 2000
- Volume
- 53
- Issue
- 9
- Pages
- 879-885
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W1985072203
- Cited by
- 257
- References
- 0
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Tubulysins, New Cytostatic Peptides from Myxobacteria Acting on Microtubuli. Production, Isolation, Physico-chemical and Biological Properties. https://app.cochat.ai/papers/10.7164/antibiotics.53.879
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- SASSE, F., SIEINMETZ, H., HEIL, J., HÖFLE, G., & REICHENBACH, H. (2000). Tubulysins, New Cytostatic Peptides from Myxobacteria Acting on Microtubuli. Production, Isolation, Physico-chemical and Biological Properties. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.53.879
Data sources
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
