Cited by 389Sepsis Diagnosis and TreatmentNeonatal and Maternal InfectionsBacterial Infections and Vaccines

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality

Open access

Jawad, Issrah, Lukšić, Ivana, Rafnsson, Snorri Bjorn·2012·Journal of Global Health

DOI 10.7189/jogh.01.010404PMC PMC3484761

Open this paper in CoChat — free account

Abstract

Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortalityObjective Sepsis is a complex and hard-to-define condition with many different interactions with other disorders.Presently, there are no estimates of the burden of sepsis and septicaemia at the global level and it was not included in the initial Global Burden of Disease study.Non-maternal sepsis has only recently received attention as a substantial global public health problem.The aim of this study was to assess available data on the burden of non-maternal sepsis, severe sepsis and septic shock in the community and to identify key gaps in information needed to estimate the global burden of sepsis.Methods Literature review of English language-based studies reporting on the incidence, prevalence, mortality or case-fatality of sepsis, severe sepsis and septic shock.The available literature was searched using the MEDLINE database of citations and abstracts of biomedical research articles published between 1980 and 2008.Findings 8 studies reported incidence of sepsis, severe sepsis or septic shock at the national level (4 from the USA and 1 from Brazil, the UK, Norway and Australia).No studies on the incidence, prevalence, mortality or case-fatality from sepsis in developing countries were found.The population sepsis incidence ranged from 22 to 240/100 000 (most plausible estimates ranged from 149 to 240/100 000); of severe sepsis from 13 to 300/100 000 (most of the estimates were between 56 and 91/100 000); and of septic shock 11/100 000.Case-fatality rate depends on the setting and severity of disease.It can reach up to 30% for sepsis, 50% for severe sepsis and 80% for septic shock.While the data were compiled using strict inclusion and exclusion criteria, a degree of uncertainty still exists regarding the reported estimates. ConclusionThe few national-level reports available allow only a very crude estimation of the incidence of sepsis in developed countries while there is apparent lack of data from developing countries.A clear and universal definition of sepsis as well as the development of a sound epidemiological framework to begin addressing the magnitude of this problem is urgently needed through research in developing countries.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.7189/jogh.01.010404

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,317
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007
The epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841
Evidence-based health policy—lessons from the Global Burden of Disease Study
Murray, C. J. L., & Lopez, A. D. (1996) · Science · doi:10.1126/science.274.5288.740 · Cited by 2,178
The Epidemiology of Severe Sepsis in Children in the United States
Watson, R. S., Carcillo, J. A., Linde‐Zwirble, W. T., Clermont, G., Lidicker, J. R., & Angus, D. C. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200207-682oc · Cited by 880
Epidemiology of sepsis in Germany: results from a national prospective multicenter study
Engel, C., Brunkhorst, F. M., Bone, H.-G., Brunkhorst, R. R., Gerlach, H., Grond, S., Gründling, M., Huhle, G., Jaschinski, U., John, S., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-006-0517-7 · Cited by 609
Sepsis: definition, epidemiology, and diagnosis
Lever, A. M. L., & Mackenzie, I. M. J. (2007) · BMJ · doi:10.1136/bmj.39346.495880.ae · Cited by 521
Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units
Finfer, S. R., Bellomo, R., Lipman, J., French, C., DOBB, G. J., & Myburgh, J. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2157-0 · Cited by 435
Brazilian Sepsis Epidemiological Study (BASES study)
Silva, E., Pedro, M. D. A., Sogayar, A. M. C. B., Mohovic, T., Silva, C. L. O., Janiszewski, M., Cal, R. G. R., de Sousa, É. F., Abe, T. P., de Andrade, J., et al. (2004) · Critical Care · doi:10.1186/cc2892 · Cited by 413

Flagged first, then by citations

Show all 24 references

Sorted by citations

Items 201–300 of 389

Pyroptosis in sepsis induced organ dysfunction
Song, R., He, S., Wu, Y., & Tan, S. (2023) · Current Research in Translational Medicine · doi:10.1016/j.retram.2023.103419 · Cited by 9
Incidence of mortality and its predictors among septic shock patients admitted to the intensive care unit of comprehensive specialized hospitals in the northwest of Amhara, Ethiopia
Mekuria, T. A., Liyew, B., Zegeye, A. F., Tadesse, E. E., & Nimani, T. D. (2024) · Frontiers in Disaster and Emergency Medicine · doi:10.3389/femer.2024.1405753 · Cited by 11
Tracking of GFP-labeled unrestricted somatic stem cells transplanted in the sepsis mouse model
Zarei‐Behjani, Z., Soleimani, M., Atashi, A., Ebrahimi‐Barough, S., Ai, J., & Hamidieh, A. A. (2019) · Tissue and Cell · doi:10.1016/j.tice.2019.07.009 · Cited by 9
Phytic Acid-Promoted Deposition of Gold Nanoparticles with Grafted Cationic Polymer Brushes for the Construction of Synergistic Contact-Killing and Photothermal Bactericidal Coatings
Huang, T., He, X., Ali, A., Sathishkumar, G., Xiang, Y., Zhang, K., Rao, X., Kang, E. T., & Xu, L. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00237 · Cited by 10
Expert consensus on the perioperative management of patients with sepsis
Chen, J.-P., Fang, X., Jin, X., Kang, R., Liu, K., Li, J., Luo, Y., Lu, Z., Miao, C., Ma, H., et al. (2015) · World Journal of Emergency Medicine · doi:10.5847/wjem.j.1920-8642.2015.04.001 · Cited by 10
Protective Effect of a Novel (2S, 3R, 4S)-Chromene-3-Carboxamide Derivative, Z20 Against Sepsis-Induced Organ Injury
Zeng, L., Wang, Y., Li, N., Niu, M., Wang, Y., & Chen, P. (2020) · Inflammation · doi:10.1007/s10753-019-01174-z · Cited by 9
Comparative Efficacy of Chinese Herbal Injections for Septic Shock: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
Huang, P., Chen, Y., Zhang, H., Chen, B., Zhao, S., Feng, Y., Lei, S., & Wu, Q. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.850221 · Cited by 13
Anesthesia-Sepsis-Associated Alterations in Liver Gene Expression Profiles and Mitochondrial Oxidative Phosphorylation Complexes
Osuru, H. P., Paila, U., Ikeda, K., Zuo, Z., & Thiele, R. H. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.581082 · Cited by 9
Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase
Wu, J., Baranowski, M. R., Aleshin, A. E., Isiorho, E. A., Lambert, L. J., Backer, L. J. S. D., Han, Y. N., Das, R., Sheffler, D. J., Bobkov, A. A., et al. (2025) · ACS Omega · doi:10.1021/acsomega.4c10321 · Cited by 8
Clinical Value of Tocilizumab in Reducing Mortality in Refractory Septic Shock in Children with Hematologic and Non-Hematologic Diseases
Lee, E., Lin, J., Chen, S., Chan, O., Su, Y.-T., Hsiao, M., Hsia, S., & Wu, H. (2025) · Cells · doi:10.3390/cells14060441 · Cited by 8
Thaliporphine, an alkaloid from Neolitsea konishii , exerts antioxidant, anti-inflammatory, and anti-apoptotic responses in guinea pig during cardiovascular collapse in inflammatory disease
Ku, H.-C., Lee, S.-Y., Lee, S., & Su, M. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.07.002 · Cited by 8
Subcellular Energetics and Metabolism: Potential Therapeutic Applications
Thiele, R. H. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001865 · Cited by 8
A Cost-Benefit Analysis of Automated Physiological Data Acquisition Systems Using Data-Driven Modeling
van Wyk, F., Khojandi, A., Williams, B., MacMillan, D., Davis, R. L., Jacobson, D., & Kamaleswaran, R. (2018) · Journal of Healthcare Informatics Research · doi:10.1007/s41666-018-0040-y · Cited by 8
Pre‐hospital antibiotic therapy preceded by blood cultures in a physician‐manned mobile emergency care unit
Mikkelsen, V. S., Gregers, M. C. T., Justesen, U. S., Schierbeck, J., & Mikkelsen, S. S. (2021) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13777 · Cited by 8
Protective effect of Apelin/APJ system on lipopolysaccharide-related cardiac dysfunction
Hu, J., Huo, S., Dou, S., Jiang, W. H., & Li, Y. (2021) · General Physiology and Biophysics · doi:10.4149/gpb_2021006 · Cited by 8
Conceitos atuais sobre suporte hemodinâmico e terapia em choque séptico
Rocha, L. L., Pessoa, C. M. S., Corrêa, T. D., Pereira, A. J., de Assunção, M. S. C., & Silva, E. (2015) · Brazilian Journal of Anesthesiology · doi:10.1016/j.bjan.2015.07.003 · Cited by 8
Impact of integrated graphical display on expert and novice diagnostic performance in critical care
Reese, T. J., Fiol, G. D., Tonna, J. E., Kawamoto, K., Segall, N., Weir, C. R., Macpherson, B. C., Kukhareva, P., & Wright, M. C. (2020) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocaa086 · Cited by 8
Diagnostic Value of RDW-Albumin Ratio for the Prediction of Mortality in Sepsis Associated Nonthyroidal Illness Syndrome Patients: A Retrospective Cohort Study
Zhang, J., Xu, P., Huang, Y., Li, J., Ma, C., Liu, G., Ye, J., Guo, Y., Feng, Z., Jiang, B., et al. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s481760 · Cited by 7
Source control in intra-abdominal infections: What you need to know
Coccolini, F., Kirkpatrick, A. W., Cremonini, C., & Sartelli, M. (2025) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000004654 · Cited by 10
Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction.
Zeng, X., Liu, D., Han, Y. Y., Huang, Z., Zhang, J., & Huang, Q. (2020) · PubMed Central · Cited by 7
Selective Response to Bacterial Infection by Regulating Siglec-E Expression
Wu, Y., Yang, D., Liu, R., Wang, L., & Chen, G. (2020) · iScience · doi:10.1016/j.isci.2020.101473 · Cited by 7
An immune genes signature for predicting mortality in sepsis patients
Lin, S., Li, P., Yang, J., Liu, S., Huang, S., Huang, Z., Zhou, C.-Y., & Liu, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1000431 · Cited by 7
Mortalidad por sepsis e infecciones complicadas en el departamento de Santander, Colombia
Niño-Mantilla, M. E., Hormiga, C. M., Blanco, I. T. O., Villarreal-Ibarra, V. P., Ardila-Acuña, L., & Torres‐Dueñas, D. (2014) · Universidad y Salud · Cited by 7
Comorbidities Might Condition the Recovery of Quality of Life in Survivors of Sepsis
Erbs, G. C., Mastroeni, M. F., Pinho, M., Köenig, Á., Sperotto, G., Ekwaru, J. P., & Westphal, G. A. (2017) · Journal of Intensive Care Medicine · doi:10.1177/0885066617699360 · Cited by 7
The serum SA levels are significantly increased in sepsis but decreased in cirrhosis
Huang, X., Yao, Q., Zhang, L., & Tian, Z. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.01.009 · Cited by 7
Pcv-aCO2/Ca-cvO2 Combined With Arterial Lactate Clearance Rate as Early Resuscitation Goals in Septic Shock
Gao, X., Cao, W., & Li, P. (2019) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2019.04.025 · Cited by 7
Fertility and Fontanels: Women's knowledge of medicinal plants for reproductive health and childcare in western Africa
Towns, A. (2014) · Leiden Repository (Leiden University) · Cited by 7
Capillary lactate as a prognostic marker in sepsis: correlation with venous lactate and prediction of outcomes
Joseph, P. A., Doluweera, D., Chandraratne, A., Balasubramaniam, B. C., Abeyratne, V., Hewa, S. P., Rambukwella, R., Wanigasuriya, K. P., Indrakumar, J., & Perera, N. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-10810-z · Cited by 6
The Protective Effects of Ruscogenin Against Lipopolysaccharide-Induced Myocardial Injury in Septic Mice
Wang, R., Wang, M.-G., Tang, H.-Z., Du, H., Luo, Y., Li, Q., Zhang, X., Fu, J., & Lv, C. (2024) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001563 · Cited by 6
Morin Ameliorates Lipopolysaccharides-Induced Sepsis-Associated Encephalopathy and Cognitive Impairment in Albino Mice
Mohamed, A. R., Fares, N. H., & Mahmoud, Y. I. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04269-8 · Cited by 6
Recombinant human activated protein C for the treatment of severe sepsis and septic shock: a study protocol for incorporating observational evidence using a Bayesian approach
Zhang, Z. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005622 · Cited by 6
QSOFA SCORE FOR DIAGNOSTICS OF SEPSIS. RESULTS OF THE RUSSIAN MULTI-CENTER TRIAL OF RISES
Аstafieva, M. N., Руднов, В. А., Кулабухов, В. В., Bagin, V. A., Zubareva, N., Tribulev, M., & Mukhacheva, S. Y. (2018) · Messenger of Anesthesiology and Resuscitation · doi:10.21292/2078-5658-2018-15-4-14-22 · Cited by 6
Switch Off “Parallel Circuit”: Insight of New Strategy of Simultaneously Suppressing Canonical and Noncanonical Inflammation Activation in Endotoxemic Mice
Yan, L., Liang, J., Zhou, Y., Huang, J., Zhang, T., Wang, X., & Yin, H. H. (2020) · Advanced Biosystems · doi:10.1002/adbi.202000037 · Cited by 6
Temporal changes in the epidemiology of sepsis‐related intensive care admissions from the emergency department in Australia and New Zealand
Jones, D. A., Moran, J. L., Udy, A. A., Pilcher, D. V., Delaney, A. P., Peake, S., & the ARISE‐TRIPS study investigators (2022) · Emergency Medicine Australasia · doi:10.1111/1742-6723.14034 · Cited by 6
Synergistic Aspects to Explain the Pathophysiology of Sepsis and Septic Shock-An Opinion
Koren, E., & Ginsburg (2015) · Journal of Infectious Diseases and Therapy · doi:10.4172/2332-0877.1000254 · Cited by 6
Can pre‐hospital administration reduce time to initial antibiotic therapy in septic patients?
Cudini, D., Smith, K. L., Bernard, S. A., Stephenson, M., Andrew, E., Cameron, P. A., Lum, M., Udy, A. A., & on behalf of the ARISE Investigators (2019) · Emergency Medicine Australasia · doi:10.1111/1742-6723.13282 · Cited by 6
Factors affecting early treatment goals of sepsis patients presenting to the emergency department
Palatty, B. U., Kassyap, C. K., Abraham, S. V., Krishnan, S., & Rajeev, P. C. (2018) · Indian Journal of Critical Care Medicine · doi:10.4103/ijccm.ijccm_27_18 · Cited by 6
Association between different concentrations of human serum albumin and 28-day mortality in intensive care patients with sepsis: A propensity score matching analysis
Xu, W., Huo, J., Cheng, G., Fu, J., Huang, X., Feng, J., & Jiang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1037893 · Cited by 5
Is procalcitonin a reliable indicator of sepsis in spinal cord injury patients: an observational cohort study
Anas, M., Hasan, T., Raja, U., & Raza, W. A. (2023) · European Spine Journal · doi:10.1007/s00586-023-07609-4 · Cited by 5
Establishment of a mortality risk nomogram for predicting in-hospital mortality of sepsis: cohort study from a Chinese single center
Wu, H., Jia, S., Liao, B., Ji, T., Huang, J., Luo, Y., Cao, T., & Ma, K. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1360197 · Cited by 5
Rain on the Parade of Influenza Vaccine Hesitancy
Eitze, S., Betsch, C., & The Vaccination60+ Study Group (2024) · European Journal of Health Psychology · doi:10.1027/2512-8442/a000154 · Cited by 5
Sepsis biomarkers dynamics as an indicator of intensive care effectiveness
Zvyagin, A. A., Демидова, В. С., & Смирнов, Г. В. (2019) · Pirogov Russian Journal of Surgery · doi:10.17116/hirurgia201902153 · Cited by 5
Presenting Symptoms in Sepsis: Is the Mnemonic “SEPSIS” Useful?
Wattanapaiboon, K., Banditlertruk, S., & Vattanavanit, V. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s263964 · Cited by 5
Are adequate fluid challenges prescribed for severe sepsis?
Courtney, M., Gopinath, B., Toward, M., Jain, R., & Rao, M. (2014) · International Journal of Health Care Quality Assurance · doi:10.1108/ijhcqa-01-2014-0013 · Cited by 5
Effectiveness and safety of procalcitonin evaluation for reducing mortality in adult patients with sepsis, severe sepsis and septic shock
Silva, B. N., Andriolo, R. B., Salomão, R., & Atallah, Á. N. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010959 · Cited by 5
The OVLT initiates the fall in arterial pressure evoked by high dose lipopolysaccharide: Evidence that dichotomous, dose-related mechanisms mediate endotoxic hypotension
Feleder, C., Yılmaz, M. S., Peng, J., Göktalay, G., & Millington, W. R. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.05.023 · Cited by 4
Challenges in the Management of Sepsis in a Resource-Poor Setting
Paul, N., & Le, Y.-I. (2017) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2017.86039 · Cited by 4
Faktor Risiko Mortalitas pada Anak dengan Syok di Ruang Perawatan Intensif Rumah Sakit dr. Moewardi Surakarta
Sutadi, K., Pudjiastuti, P., & Martuti, S. (2020) · Sari Pediatri · doi:10.14238/sp22.1.2020.7-12 · Cited by 4
The burden and prognostic significance of suspected sepsis in the prehospital setting: A state‐wide population‐based cohort study
Chatoor, R., Sekhar, P., Mahony, E., Nehme, E., Cox, S., Cudini, D., Shao, J., Smith, K. L., Anderson, D. J., Nehme, Z., et al. (2023) · Emergency Medicine Australasia · doi:10.1111/1742-6723.14357 · Cited by 4
Fluid resuscitation in severe sepsis and septic shock: Shifting goalposts
Bhatia, P., & Biyani, G. (2015) · Indian Journal of Anaesthesia · doi:10.4103/0019-5049.156863 · Cited by 4
Prognostic value of the biomarker copeptin in critically ill patients with sepsis
Naguib, M., Sobhy, E., Hammad, M., & Rashed, L. (2016) · Kasr Al Ainy Medical Journal · doi:10.4103/1687-4625.195893 · Cited by 4
Effectiveness of provider strategies for the early recognition of clinical deterioration due to sepsis in pediatric patients: a systematic review protocol
Patton, L. J., & Young, V. (2017) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2016-003237 · Cited by 5
Sepsis in Low- and Middle-Income Countries
Azevedo, L. C. P., & Machado, F. R. (2018) · Springer eBooks · doi:10.1007/978-3-319-73506-1_15 · Cited by 4
Clinical Outcomes of Community-Acquired Severe Sepsis after Implementation of a Simple Severe Sepsis Fast Track.
Ruangchan, S., Chusri, S., Saengsanga, P., Kiamkan, N., Phunpairoth, P., & Chayakul, P. (2016) · PubMed · Cited by 4
The Diagnostic Values of Peptidoglycan, Lipopolysaccharide, and (1,3)-Beta-D-Glucan in Patients with Suspected Bloodstream Infection: A Single Center, Prospective Study
Zhao, Y. Y., Wang, Z., Zhang, X., Wang, Y., Yang, W., & Xu, Y.-C. (2022) · Diagnostics · doi:10.3390/diagnostics12061461 · Cited by 4
Assessment of 28-day survival of patients with sepsis based on vitamin D status: hospital-based prospective cohort study in Indonesia
Asdie, R. H., Mulya, D. P., & Nainggolan, M. (2023) · Pan African Medical Journal · doi:10.11604/pamj.2023.45.76.36336 · Cited by 4
Sepsis in Vulnerable Populations
Bhagwanjee, S., & Ugarte, S. (2014) · Global Heart · doi:10.1016/j.gheart.2014.08.008 · Cited by 4
Efficacy of measuring procalcitonin levels in determination of prognosis and early diagnosis of bacterial resistance in sepsis
Hatamabadi, H., Dolatabadi, A. A., Memary, E., Amini, A., Shojaee, M., & Abdalvand, A. (2015) · Nigerian Medical Journal · doi:10.4103/0300-1652.149165 · Cited by 4
Prognostic Value of a Genetic Polymorphism in Promotor Region of AQP5 in Sepsis Depends on the Source of Infection
Писарев, В. М., Чумаченко, А. Г., Turin, I. N., Cherpakov, R. A., Elisina, E. V., Grigoriev, E. K., Aleksandrov, I. A., & Tutelyan, A. V. (2020) · General Reanimatology · doi:10.15360/1813-9779-2020-3-16-33 · Cited by 4
A Comparative Study to Assess the Determinants and Outcomes of Sepsis Treated in Medical Wards and ICU in an Indian Teaching Hospital
Bhattacharya, P. K. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/18114.7949 · Cited by 4
Comparison of Quick Sequential Organ Failure Assessment and Modified Systemic Inflammatory Response Syndrome Criteria in a Lower Middle Income Setting.
Beane, A., Silva, A. P. D., Munasinghe, S. B., Silva, N. D., Arachchige, S. J., Athapattu, P. L., Sigera, C., Miskin, M. F., Liyanagama, P. M., Rathnayake, R. M. D., et al. (2017) · PubMed Central · doi:10.6705/j.jacme.2017.0704.002 · Cited by 4
Effect of simple-bundles management vs. guideline-bundles management on elderly patients with septic shock: a retrospective study
Yang, Q., Wang, Z., & Guan, J. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-20-2320 · Cited by 4
Fluid Resuscitation in Pediatric Septic Shock: The Case Against Haste*
Kortz, T. B., & Kissoon, N. “. (2017) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001272 · Cited by 4
Physiomarkers in Real-Time Physiological Data Streams Predict Adult Sepsis Onset Earlier Than Clinical PracticePreprint
van Wyk, F., Khojandi, A., Davis, R. L., & Kamaleswaran, R. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/322305 · Cited by 4
Sepsis and septic shock in COVID-19: a scoping review of the research dataPreprint
Lakoh, S., Jiba, D. F., Baldeh, M., Vandy, A. O., Benya, H., Lado, M., Sevalie, S., Yendewa, G. A., & Sahr, F. (2020) · doi:10.21203/rs.3.rs-30474/v1 · Cited by 4
Approaches to enhance the antimicrobial activity of carbapenems within bacterial biofilms
Lamb, M. A., Wiedbrauk, S., & Fairfull‐Smith, K. E. (2024) · RSC Pharmaceutics · doi:10.1039/d4pm00141a · Cited by 3
Effect of different shock conditions on mesenteric hemodynamics
Pu, H., Li, W., Wang, G., & Zhou, S. (2024) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2024.08.018 · Cited by 3
Clinical significance of the neutrophil‐to‐lymphocyte ratio on the prognosis of critically ill elderly patients with sepsis— a retrospective study based on the MIMICV‐IV database
Han, K., Wang, J., & Lu, J. S. (2025) · Hong Kong Journal of Emergency Medicine · doi:10.1002/hkj2.70008 · Cited by 3
Biomarkers during intensive care for sepsis
Zvyagin, A. A., Демидова, В. С., & Смирнов, Г. В. (2019) · Wounds and wound infections The prof B M Kostyuchenok journal · doi:10.25199/2408-9613-2018-6-1-34-38 · Cited by 3
Immunological responses of septic rats to combination therapy with thymosin α1 and vitamin C
Zhang, D., Wang, L., Wang, Z., Shi, X., Tang, W. H., Jiang, L., Yi, B. Y. C. H. B. R., Lv, X., Hu, C., & Xiao, D. (2023) · Open Life Sciences · doi:10.1515/biol-2022-0551 · Cited by 4
Characteristics of bacterial sepsis among patients with visceral leishmaniasis
Endris, M., Takele, Y., Woldeyohannes, D., Unakal, C. G., Moges, F., Tiruneh, M., & Diro, E. (2014) · Asian Pacific Journal of Tropical Biomedicine · doi:10.12980/apjtb.4.2014c1133 · Cited by 3
Senkung der Mortalität bei Erwachsenen mit Sepsis, schwerer Sepsis oder septischem Schock: Wirksamkeit und Sicherheit von Procalcitonin
Schneidewind, L. (2021) · Der Urologe · doi:10.1007/s00120-021-01506-8 · Cited by 3
Cutoff Values of Hemodynamic Parameters in Pediatric Refractory Septic Shock
Lee, E., Lin, J., Hsia, S., Chan, O., Jan, S., & Wu, H. (2022) · Children · doi:10.3390/children9030303 · Cited by 3
Diastolic blood pressure impact on pediatric refractory septic shock outcomes
Lee, E., Yen, C.-W., Hsieh, M., Lin, J., Chan, O., Su, Y.-T., Mu, C.-T., Wu, H., & Hsia, S. (2023) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2023.02.010 · Cited by 4
Evaluating the Impact of Source-specific Order Sets for Sepsis on Empiric Antibiotic Selection in the Emergency Department
Alvarado, L. R. M., Landayan, A. M., Morell, J., Wasielewski, A., Zhang, Z., Levine, R., & Gauthier, T. P. (2023) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad677 · Cited by 3
Sepsis 3-hour bundle compliance and prognosis in emergency department patients aged 65 years or older
Carbó, M., Osorio, G. I., Fresco, L., Hernández, N. M., Gainza, M. P., & Romero, M. D. M. O. (2024) · Emergencias · doi:10.55633/s3me/009.2024 · Cited by 3
Significance of Right Ventricular Dysfunction in Predicting Short‐Term Survival Among Patients With Sepsis and Septic Shock: A Prognostic Analysis
Koowattanatianchai, S., Kochaiyapatana, P., Eungsuwat, N., Rangsrisaeneepitak, V., Thammakumpee, K., & Kaladee, K. (2025) · Critical Care Research and Practice · doi:10.1155/ccrp/5511135 · Cited by 3
Does Celiac Disease Influence Survival in Sepsis? A Nationwide Longitudinal Study
Tjernberg, A. R., Bonnedahl, J., & Ludvigsson, J. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154663 · Cited by 3
A method to monitor urinary carbon dioxide in patients with septic shock
Atherton, J. G., King William, E., Guziński, M., Jasinski, A., Pendley, B. D., & Lindner, E. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.05.076 · Cited by 3
Biological marker medications in the diagnosis and treatment of sepsis (literature review)
Zvyagin, A. A., Демидова, В. С., & Смирнов, Г. В. (2016) · Wounds and wound infections The prof B M Kostyuchenok journal · doi:10.17650/2408-9613-2016-3-2-19-23 · Cited by 3
Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens
Jia, N. Z., Asiri, S. M., Elsharif, A. M., Alamoudi, W., Al-Suhaimi, E. A., & Kim, S. (2021) · Applied Sciences · doi:10.3390/app11178067 · Cited by 3
Hemodynamic profiles related to circulatory shock in cardiac care units
González-Hermosillo, J. A., Palma-Carbajal, R., Velasco, G. R., Jardines, R. C., González-Galván, L. M., Manzur‐Sandoval, D., Jiménez‐Rodrìguez, G. M., & Ortiz-Solis, W. A. (2020) · Archivos de cardiolog�a de M�xico (English ed Internet) · doi:10.24875/acme.m20000094 · Cited by 3
Clinical Significance of MicroRNAs in Patients with Sepsis: Protocol for a Systematic Review and Meta-Analysis
Hasegawa, D., Yamakawa, K., Taniguchi, K., Murao, S., & Nishida, O. (2019) · Diagnostics · doi:10.3390/diagnostics9040211 · Cited by 3
Amino Acid Composition and Charge Based Prediction of Antisepsis Peptides by Random Forest Machine Learning AlgorithmPreprint
Rathore, A., Saini, A., Kaur, N., Singh, A., Dutta, O., Bamhotra, M., Saini, A., & Saini, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.26.461860 · Cited by 3
Incidence and mortality of community-acquired and nosocomial infections in Japan: a nationwide medical claims database study
Takahashi, N., Imaeda, T., Oami, T., Abe, T., Shime, N., Komiya, K., Kawamura, H., Yamao, Y., Fushimi, K., & Nakada, T. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-09353-6 · Cited by 3
Non-ionic surfactant vesicles exert anti-inflammatory effects through inhibition of NFκB
McGahon, J., Woods, S., D’Elia, R. V., & Roberts, C. W. (2024) · Journal of Inflammation · doi:10.1186/s12950-024-00419-5 · Cited by 2
Prognostic value of laboratory markers of sepsis in patients in critical condition
Vershinina, M. G., Steriopolo, N. A., & Ibragimova, V. Y. (2019) · Laboratory Service · doi:10.17116/labs2019804129 · Cited by 2
Using age, arterial lactate level and sequential organ failure assessment score in risk stratification of sepsis syndromes
Elmorsi, A., Dahroug, A. H., Fahmy, E., & Ahmed, I. (2019) · Signa Vitae · doi:10.22514/sv151.042019.6 · Cited by 2
Open or closed abdomen post laparotomy to control severe abdominal sepsis: a survival analysis
SHEHADEH, I., de Andrade, L., SILVA, A. I. L. F. D., Iora, P. H., KNAUT, E. F., Duarte, G. C., & Fontes, C. E. R. (2024) · Revista do Colégio Brasileiro de Cirurgiões · doi:10.1590/0100-6991e-20243595-en · Cited by 2
Jinhong decoction ameliorates injury in septic mice without disrupting the equilibrium of gut microbiota
Liang, T. X., Liu, Y., Guo, N., Li, Y., Niu, L., Liu, J., Ma, Q., Zhang, J., & Shan, M. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116404 · Cited by 2
Early Prediction of Sepsis Using Ensembled Learning
Akinduyite, C. O., Badeji–Ajisafe, B., Obamiyi, S. E., Oguntimilehin, A., Oluwatoyin, O., Tope-Oke, A. M., Jaiyesinmi, K. F., Abiola, O. B., & Ayogu, B. (2024) · International Conference on Science, Engineering and Business for Driving Sustainable Development Goals (SEB4SDG) · doi:10.1109/seb4sdg60871.2024.10629800 · Cited by 2
Urinary pCO2 Monitoring System with a Planar Severinghaus Type Sensor
Atherton, J. G., Pendley, B. D., Guziński, M., Bissler, J. J., & Lindner, E. (2022) · Electroanalysis · doi:10.1002/elan.202100678 · Cited by 2
Pediatric Sepsis Diagnosis Based on Differential Gene Expression and Machine Learning Method
Vu, L. D., Pham, V.-S., Nguyen, M. T., & Le, H.-C. (2022) · International Conference on Knowledge and Systems Engineering/Proceedings · doi:10.1109/kse56063.2022.9953619 · Cited by 2
PROGNOSTIC EVALUATION OF LABORATORY BLOOD PARAMETERS IN SEPTIC PATIENTS OF INTENSIVE CARE UNIT
Anfinogenova, O., Muratovа, A., Vlasov, A., Борисовна, Э. А., & Николаевна, Д. И. (2022) · Archiv Euromedica · doi:10.35630/2022/12/6.4 · Cited by 2
MYC Participates in Lipopolysaccharide-Induced Sepsis via Promoting Cell Proliferation and Inhibiting Apoptosis.
Li, Y., Kong, C. H., Feng, L., Tang, W., Chen, M., & Zheng, Z. (2020) · PubMed Central · doi:10.22074/cellj.2020.6961 · Cited by 2
Trends in antimicrobial resistance amongst pathogens isolated from blood and cerebrospinal fluid cultures in Pakistan (2011-2015): a retrospective cross-sectional studyPreprint
Javaid, N., Sultana, Q., Rasool, K., Gandra, S., Ahmad, F., Chaudhary, S. U., & Mirza, S. (2020) · doi:10.21203/rs.2.21817/v1 · Cited by 2
Carbon monoxide licensing of MSCs enhances their efficacy through autophagy-mediated miRNA mechanisms
Dunbar, H., Hawthorne, I. J., & English, K. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.06.008 · Cited by 1
PROGNOSTIC VALUE OF THE ENTERAL INSUFFICIENCY SCORE II IN PERITONITIS DUE TO COMPLICATED INTRA-ABDOMINAL INFECTION
Syplyviy, V., Євтушенко, О. В., Євтушенко, Д. В., Dotsenko, V. V., & Grinchenko, S. V. (2025) · Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії · doi:10.31718/2077-1096.25.3.96 · Cited by 1
The effectiveness of synthetic glucocorticoids on the disease course, treatment, and outcome of severe sepsis and septic shock
Dumančić, J., Čupić, M., Potočnjak, I., Trbušić, M., & Degoricija, V. (2016) · Endocrine Oncology and Metabolism · doi:10.21040/eom/2016.2.8 · Cited by 1
Severe Sepsis and Septic Shock – New Guidelines, 2012
(2014) · Clinical Microbiology Open Access · doi:10.4172/2327-5073.1000e117

Authors: Jawad, I., Lukšić, I., & Rafnsson, S. B.
Affiliations: University of Edinburgh (GB)
ORCID: Jawad, Issrah
Lukšić, Ivana
Venue: Journal of Global Health
Publisher: International Global Health Society
Published: 2012-06
Volume: 2
Issue: 1
Pages: 010404-010404
ISSN: 2047-2978 (ISSN-L)
2047-2986
DOI: 10.7189/jogh.01.010404
PMC: PMC3484761
OpenAlex: W4237666362
Cited by: 389
References: 24
Citations by year: 2026: 2 · 2025: 16 · 2024: 29 · 2023: 26 · 2022: 24 · 2021: 31 · 2020: 53 · 2019: 34 · 2018: 37 · 2017: 32 · 2016: 44 · 2015: 28 · 2014: 24 · 2013: 9
FWCI: 14.55
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Journal of Global Health (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Keywords: sepsis, severe sepsis, septic shock, global burden of disease, incidence, prevalence, mortality, case fatality rate, data gaps, developing countries, sepsis epidemiology, sepsis definitions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks