The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Heparin-Associated Thrombocytopenia
Abstract
Heparin-associated thrombocytopenia is a relatively common complication of heparin therapy occurring in approximately 5% of the patients who receive this drug. The incidence is higher with bovine heparin then with porcine heparin. Onset of heparin-associated thrombocytopenia usually occurs 6 to 12 days after initiation of treatment and by itself has a low morbidity. Heparin-associated thrombocytopenia plus arterial thrombosis can cause major complications including stroke, heart attack, and death. The incidence of heparin-associated thrombocytopenia plus arterial thrombosis is lower than that for heparin-associated thrombocytopenia alone. The diagnosis of heparin-associated thrombocytopenia remains one of exclusion, but testing for the presence of a heparin-dependent platelet-aggregating factor may prove to be useful. Analysis of the time of onset suggests a strategy for prevention. Oral anticoagulants could be started concomitantly with the heparin so that it could be discontinued in several days. This approach may prevent most episodes of heparin-associated thrombocytopenia.
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Citations
Cites
Effect of Heparin and Heparin Fractions on Platelet Aggregation
Salzman, E. W., Rosenberg, R. D., Smith, M. H., Lindon, J. N., & Favreau, L. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109661 · Cited by 591
Heparin-Associated Thrombocytopenia: A Comparison of Three Heparin Preparations
Bell, W. R., & Royall, R. M. (1980) · New England Journal of Medicine · doi:10.1056/nejm198010163031602 · Cited by 208
Thrombotic Complications of Heparin Therapy Including Six Cases of Heparin-Induced Skin Necrosis
WHITE, P. W., SADD, J. R., & NENSEL, R. E. (1979) · Annals of Surgery · doi:10.1097/00000658-197911000-00007 · Cited by 167
Bleeding associated with antithrombotic therapy.
Jg, K., & Hirsh, J. (1980) · PubMed · Cited by 147
The Potentiation of Platelet Aggregation and Adhesion by Heparin in Vitro and in Vivo
Thomson, C. L., Forbes, C. D., & Prentice, C. R. M. (1973) · Clinical Science · doi:10.1042/cs0450485 · Cited by 134
Impairment by Heparin of Primary Haemostasis and Platelet [14C]5‐Hydroxytryptamine Release
Heiden, D., Mielke, C. H., & Rodvien, R. (1977) · British Journal of Haematology · doi:10.1111/j.1365-2141.1977.tb00666.x · Cited by 117
Cited by
Prevention of Venous Thromboembolism
Geerts, W. H., Heit, J. A., Clagett, G. P., Pineo, G. F., Colwell, C. W., Anderson, F. A., & Wheeler, H. B. (2001) · Chest · doi:10.1378/chest.119.1_suppl.132s · Cited by 4,373
Warkentin, T. E., Levine, M. N., Hirsh, J., Horsewood, P., Roberts, R. S., Gent, M., & Kelton, J. G. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322003 · Cited by 2,328
Self-citationOates, J. A., Wood, A. J. J., & Hirsh, J. (1991) · New England Journal of Medicine · doi:10.1056/nejm199105303242206 · Cited by 830
Argatroban Anticoagulant Therapy in Patients With Heparin-Induced Thrombocytopenia
Lewis, B. E., Wallis, D. E., Berkowitz, S. D., Matthai, W. H., Fareed, J., Walenga, J. M., Bartholomew, J., Sham, R., Lerner, R. G., Zeigler, Z. R., et al. (2001) · Circulation · doi:10.1161/01.cir.103.14.1838 · Cited by 664
Self-citationHirsh, J., Dalen, J. E., Deykin, D., & Toller, L. (1992) · Chest · doi:10.1378/chest.102.4_supplement.337s · Cited by 558
Metadata
- Authors
- KING, D. J., & KELTON, J. G.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1984-04-01
- Volume
- 100
- Issue
- 4
- Pages
- 535-540
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2076315269
- Cited by
- 480
- References
- 6
- FWCI
- 22.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- KING, D. J., & KELTON, J. G. (1984). Heparin-Associated Thrombocytopenia. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-100-4-535
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
