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Bronchoalveolar Lavage in the Diagnosis of Diffuse Pulmonary Infiltrates in the Immunosuppressed Host
Abstract
The usefulness of bronchoalveolar lavage in the diagnosis of pulmonary infiltrates in the immunosuppressed patient was studied in 97 patients. In immunosuppressed patients, the available diagnostic procedures are often invasive and have variable yield and a potential for serious complications. Bronchoalveolar lavage had an overall diagnostic yield of 66% (61 of 92 diseases). It was most effective in the diagnosis of opportunistic infections, including infection with Pneumocystis carinii (18 of 22 cases), cytomegalovirus pneumonia (10 of 12 cases), fungal pneumonia (5 of 6 cases), and mycobacterial disease (4 of 5 cases). The technique was also helpful in suspected pulmonary hemorrhage (7 of 9 cases) but was less useful for diagnosing malignancy (10 of 22 cases) and drug-induced toxicity (6 of 15 cases). Findings of bronchoalveolar lavage could be combined with those of transbronchial biopsies, brushings, and washings in the diagnosis of most of the diseases. The procedure was safe, even in thrombocytopenic patients and those requiring mechanical ventilatory support. Bronchoalveolar lavage is a valuable procedure for evaluation of pulmonary disease in the immunosuppressed host.
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Cited by
Schmidt, G. M., Horak, D. A., Niland, J. C., Duncan, S. R., Forman, S. J., Zaia, J. A., & the City of Hope–Stanford–Syntex CMV Study Group* (1991) · New England Journal of Medicine · doi:10.1056/nejm199104113241501 · Cited by 616
The Prognosis of Acute Respiratory Failure in Critically Ill Cancer Patients
Azoulay, É., Thiéry, G., Chevret, S., Moreau, D., Darmon, M., Bergeron, A., Yang, K., Meignin, V., Ciroldi, M., Le Gall, J.-R., et al. (2004) · Medicine · doi:10.1097/01.md.0000145370.63676.fb · Cited by 329
Baughman, R. P., Rhodes, J. C., Dohn, M. N., Henderson, H., & Frame, P. T. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.5.1226 · Cited by 77
Factors Associated with Fatal Hemoptysis in Cancer Patients
Panos, R. J., Barr, L. F., Walsh, T. J., & Silverman, H. J. (1988) · Chest · doi:10.1378/chest.94.5.1008 · Cited by 59
Metadata
- Authors
- STOVER, D. E., ZAMAN, M. B., HAJDU, S. I., LANGE, M., GOLD, J., & ARMSTRONG, D.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1984-07-01
- Volume
- 101
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1993874069
- Cited by
- 513
- References
- 0
- FWCI
- 46.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Bronchoalveolar Lavage in the Diagnosis of Diffuse Pulmonary Infiltrates in the Immunosuppressed Host. https://app.cochat.ai/papers/10.7326/0003-4819-101-1-1
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- STOVER, D. E., ZAMAN, M. B., HAJDU, S. I., LANGE, M., GOLD, J., & ARMSTRONG, D. (1984). Bronchoalveolar Lavage in the Diagnosis of Diffuse Pulmonary Infiltrates in the Immunosuppressed Host. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-101-1-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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