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Cited by 423Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

L-Thyroxine Therapy in Subclinical Hypothyroidism: A Double-Blind, Placebo-Controlled Trial

COOPER, DAVID S., HALPERN, RACHELLE, WOOD, LAWRENCE C., LEVIN, ANN A., RIDGWAY, E. CHESTER·1984·Annals of Internal Medicine
DOI 10.7326/0003-4819-101-1-18
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Abstract

The indications for treating patients with subclinical hypothyroidism (normal serum thyroxine and free thyroxine levels, but elevated serum thyrotrophin levels) are poorly defined. In this study, 33 patients with subclinical hypothyroidism were randomly assigned in a double-blind manner to receive placebo or L-thyroxine therapy and were followed for 1 year with thyroid function tests, serum lipid measurements, basal metabolic rate and systolic time interval determinations, and a questionnaire on hypothyroid symptoms. The placebo group showed no changes in thyroid function or peripheral indices of thyroid hormone action. In the thyroxine-treated group, serum lipids and the mean systolic time interval did not change, but the systolic time intervals became normal in the 5 patients with the most abnormal baseline values. Symptoms improved in 8 of 14 patients receiving thyroxine and in 3 of 12 patients receiving placebo (p less than 0.05). L-Thyroxine therapy may be useful for patients with subclinical hypothyroidism with abnormal myocardial contractility or symptoms consistent with mild hypothyroidism, or both.

Overview

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Crossref · 10.7326/0003-4819-101-1-18

Cites

27 of 27 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 27 references

Research works printed but not linked: 2

  1. BILLEWICZ W, 1969, Q J Med., 38, 255
  2. BAGNASCO M, 1982, J Nucl Med Allied Sci., 26, 161

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Metadata

Authors
COOPER, D. S., HALPERN, R., WOOD, L. C., LEVIN, A. A., & RIDGWAY, E. C.
Affiliations
  • Harvard University (US)
  • Boston, Massachusetts
Corresponding author
COOPER, DAVID S.
ORCID
COOPER, DAVID S.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1984-07-01
Volume
101
Issue
1
Pages
18-24
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-101-1-18
OpenAlex
W1976274614
Cited by
423
References
27
Citations by year
2026: 1 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 11 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 19 · 2012: 17
FWCI
9.48
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
subclinical hypothyroidism, L-thyroxine therapy, thyroid hormone replacement, thyroid-stimulating hormone, serum lipids, basal metabolic rate, systolic time intervals, cardiac contractility
MeSH terms
Adult, Aged, Double-Blind Method, Drug Evaluation, Female, Humans, Hypothyroidism, Male, Middle Aged, Myocardial Contraction, Prolactin, Random Allocation, Thyrotropin, Thyrotropin-Releasing Hormone, Thyroxine

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