Cited by 423Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

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L-Thyroxine Therapy in Subclinical Hypothyroidism: A Double-Blind, Placebo-Controlled Trial

COOPER, DAVID S., HALPERN, RACHELLE, WOOD, LAWRENCE C., LEVIN, ANN A., RIDGWAY, E. CHESTER·1984·Annals of Internal Medicine

DOI 10.7326/0003-4819-101-1-18

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Abstract

The indications for treating patients with subclinical hypothyroidism (normal serum thyroxine and free thyroxine levels, but elevated serum thyrotrophin levels) are poorly defined. In this study, 33 patients with subclinical hypothyroidism were randomly assigned in a double-blind manner to receive placebo or L-thyroxine therapy and were followed for 1 year with thyroid function tests, serum lipid measurements, basal metabolic rate and systolic time interval determinations, and a questionnaire on hypothyroid symptoms. The placebo group showed no changes in thyroid function or peripheral indices of thyroid hormone action. In the thyroxine-treated group, serum lipids and the mean systolic time interval did not change, but the systolic time intervals became normal in the 5 patients with the most abnormal baseline values. Symptoms improved in 8 of 14 patients receiving thyroxine and in 3 of 12 patients receiving placebo (p less than 0.05). L-Thyroxine therapy may be useful for patients with subclinical hypothyroidism with abnormal myocardial contractility or symptoms consistent with mild hypothyroidism, or both.

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THE SPECTRUM OF THYROID DISEASE IN A COMMUNITY: THE WHICKHAM SURVEY
Tunbridge, W. M. G., Evered, D. C., Hall, R., Appleton, D. R., BREWIS, M., CLARK, F., Evans, J. G., Young, E. T., Bird, T., & Smith, P. (1977) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1977.tb01340.x · Cited by 2,665
Grades of Hypothyroidism
Evered, D. C., Ormston, B. J., Smith, P., Hall, R., & Bird, T. (1973) · BMJ · doi:10.1136/bmj.1.5854.657 · Cited by 323
Natural history of autoimmune thyroiditis.
Tunbridge, W. M. G., BREWIS, M., French, J. M., Appleton, D. R., Bird, T., CLARK, F., Evered, D. C., Evans, J. G., Hall, R., Smith, P., et al. (1981) · BMJ · doi:10.1136/bmj.282.6260.258 · Cited by 269
Noninvasive Evaluation of Cardiac Function in Hypothyroidism
Crowley, W. F., Ridgway, E. C., Bough, E. W., Francis, G. S., Daniels, G. H., KOURIDES, I. A., Myers, G. S., & Maloof, F. (1977) · New England Journal of Medicine · doi:10.1056/nejm197701062960101 · Cited by 238
Self-citation
Spectrum of Pituitary Alteration with Mild and Severe Thyroid Impairment* †
Bigos, S. T., Ridgway, E. C., KOURIDES, I. A., & Maloof, F. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-46-2-317 · Cited by 184
Self-citation
STATISTICAL METHODS APPLIED TO THE DIAGNOSIS OF HYPOTHYROLDISM
Billewicz, W. Z., CHAPMAN, R. S., Crooks, J., DAY, M. E., GOSSAGE, J., Wayne, E. J., & YOUNG, J. A. (1969) · QJM · doi:10.1093/oxfordjournals.qjmed.a067179 · Cited by 183
The Aging Thyroid
Sawin, C. T. (1979) · JAMA · doi:10.1001/jama.1979.03300030019013 · Cited by 176
Hypothyroidism as a Late Sequela in Patients with Graves' Disease Treated with Antithyroid Agents
Wood, L. C., & Ingbar, S. H. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109601 · Cited by 173
Self-citation
Serum prolactin levels in untreated primary hypothyroldism
Honbo, K. S., Herle, A. J. V., & Kellett, K. A. (1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90517-x · Cited by 173
Thyroid Hormone Inhibition of the Prolactin Response to Thyrotropin-Releasing Hormone
Snyder, P. J., JACOBS, L. S., Utiger, R. D., & Daughaday, W. H. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107421 · Cited by 153

Show all 27 references

Research works printed but not linked: 2

BILLEWICZ W, 1969, Q J Med., 38, 255
BAGNASCO M, 1982, J Nucl Med Allied Sci., 26, 161

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Sawin, C. T. (1997) · Humana Press eBooks · doi:10.1007/978-1-4757-2594-0_7 · Cited by 4
Hypothyroidism and Endothelial Function: A Marker of Early Atherosclerosis?
Dardano, A., & Monzani, F. (2008) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/187221408784534222 · Cited by 4
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Merchante-Alfaro, A., Civera-Andrés, M., Atiénzar-Herráez, N., Tenías-Burillo, J. M., Ochoa-Ávila, E., & Martínez-Moreno, I. (2006) · Medicina Clínica · doi:10.1157/13085287 · Cited by 4
Fonction et dysfonctions thyroïdiennes des personnes âgées
Schlienger, J.-L., Goichot, B., Grünenberger, F., & Sapin, R. (1996) · La Revue de Médecine Interne · doi:10.1016/0248-8663(96)87151-7 · Cited by 4
Thyroid and cardiovascular system
Gallowitsch, H. J. (2005) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-005-0218-9 · Cited by 4
Subclinical hypothyroidism. To treat or not to treat.
Laryea, E. A. (1993) · PubMed Central · Cited by 4
Certainty, Leaps of Faith, and Tradition
Dzurec, L. C. (1998) · Advances in Nursing Science · doi:10.1097/00012272-199812000-00006 · Cited by 4
[Sub-clinical hypothyroidism, towards the end of a controversy?].
Schlienger, J.-L., Goichot, B., Vinzio, S., Perrin, A.-E., Grünenberger, F., & Sapin, R. (2003) · PubMed · Cited by 4
Thyroid Disease and the Skin
Kasumagić-Halilović, E. (2014) · Cited by 3
Thyroid and Cardiovascular Risk
Waring, A. C., & Cappola, A. R. (2009) · Springer eBooks · doi:10.1007/978-88-470-1143-4_14 · Cited by 3
Galactorrhea in Subclinical Hypothyroidism.
Takai, T., Yamamoto, K., Saito, K., ANDO, K., Saito, T., & Kuzuya, T. (1987) · Endocrinologia Japonica · doi:10.1507/endocrj1954.34.539 · Cited by 3
Relationship between serum free thyroid hormone concentrations and target organ responsiveness in thyroid disease patients before and after treatment.
Yoshida, K., SAKURADA, T., KAISE, K., KAISE, N., Nomura, T., ITAGAKI, Y., Yamamoto, M., Saito, S., & YOSHINAGA, K. (1989) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.159.323 · Cited by 3
Alteraciones endocrinas en la esclerosis sistémica
Lastra, O. L. V., & Jara, L. J. (2006) · Reumatología Clínica · doi:10.1016/s1699-258x(06)73106-0 · Cited by 3
Hypothyroidism: A Comprehensive Review
Johnson, J. L., & Felicetta, J. V. (1992) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.1992.tb00826.x · Cited by 3
Subclinical Hypothyroidism and Cardiovascular Risk—An Overview of Current Understanding
Feldt‐Rasmussen, U. (2010) · US Endocrinology · doi:10.17925/use.2010.06.1.92 · Cited by 3
Subclinical hypothyroidism: to treat or not to treat?
Tamilia, M., & Silva, J. E. (2001) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200110000-00004 · Cited by 3
Thyrotropin Measurements: Past, Present, and Future
Utiger, R. D. (1988) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)64925-8 · Cited by 3
Inhibited Hypothalamic-Pituitary-Thyroid Axis in Type I Pseudohypoparathyroidism
Kabadi, U. M., & Cech, R. P. (1999) · Endocrine Practice · doi:10.4158/ep.5.2.61 · Cited by 3
The Thyroid Gland
Bürgi, H. (1986) · Springer eBooks · doi:10.1007/978-3-642-70509-0_6 · Cited by 3
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Kalantari, S., & Heidarzadeh, A. (2006) · Cited by 2
Hipotiroidismo en el anciano
Calvo, M., & Gonzalo, J. G. Y. (2002) · Medicina de Familia SEMERGEN · doi:10.1016/s1138-3593(02)74392-x · Cited by 2
Subclinical hypothyroidism in women: who to treat.
Morocco, M., & Kloss, R. (2002) · Disease-a-month : DM · doi:10.1053/cjwh.2000.19079 · Cited by 2
Assessment of Serum Levels of Prolactin in Sudanese female patients with Primary Hypothyroidism- Khartoum State, Sudan
Elzobir, N. F. A. (2014) · Asian journal of biomedical and pharmaceutical sciences · doi:10.15272/ajbps.v4i32.491 · Cited by 2
[Subclinical thyroid dysfunction. Diagnostic and therapeutic considerations].
Ramos, D., & Pérez-Enríquez, B. (2006) · PubMed · Cited by 3
Thyroid Heart Disease in the Elderly
Miller, M., & Gambert, S. R. (2013) · doi:10.1201/b15156-24 · Cited by 2
Hypothyroidism
McDermott, M., & Ridgway, E. C. (2009) · CRC Press eBooks · doi:10.3109/9781420070651-5 · Cited by 2
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Effect of L-thyroxine treatment versus a placebo on serum lipid levels in patients with sub-clinical hypothyroidism
Li, X., Meng, Z., Jia, Q., & Ren, X. (2016) · Biomedical Reports · doi:10.3892/br.2016.745 · Cited by 2
Thyroid Heart Disease in the Elderly
Miller, M., & Gambert, S. R. (2008) · Fundamental and clinical cardiology · doi:10.3109/9781420061710.020 · Cited by 2
Thyroid and Cardiovascular Risk
den Elzen, W. P. J., Mooijaart, S. P., Ballieux, B. E. P. B., Cappola, A. R., & Gussekloo, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-36871-5_16 · Cited by 2
Periodic health examination, 1990 update: 1. Early detection of hyperthyroidism and hypothyroidism in adults and screening of newborns for congenital hypothyroidism. Canadian Task Force on the Periodic Health Examination.
(1990) · Europe PMC (PubMed Central) · Cited by 2
Effectiveness of Combined Treatment with L-Thyroxine and Iron Proteinsuccinylate in Patients with Subclinical Hypothyroidism and Manifested Sideropenic Anemia
Duntas, L. H., Krassas, G. E., Mantzou, A., & Koutras, D. A. (2000) · Nutritional Neuroscience · doi:10.1080/1028415x.2000.11747340 · Cited by 2
Evaluation of a three-month trial of thyroxine replacement in symptomatic subclinical hypothyroidism: An impact on clinical presentation, quality of life and adoption of long-term therapy
Pandrc, M. S., Ristić, A., Kostovski, V., Randjelovic-Krstic, V., Milin-Lazovic, J. S., Nedeljković-Beleslin, B., & Ćirić, J. (2018) · Vojnosanitetski pregled · doi:10.2298/vsp180708157p · Cited by 3
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Rovó, A., & Tichelli, A. (2013) · doi:10.1002/9781118473306.ch24 · Cited by 2
Antithyroid Antibodies: Behavioral Significance
Reus, V. I., & Freimer, N. F. (1990) · Springer eBooks · doi:10.1007/978-3-642-74034-3_36 · Cited by 2
Subclinical hypothyroidism revisited
Goldmann, D. R. (1996) · Journal of General Internal Medicine · doi:10.1007/bf02598999 · Cited by 2
SUBCLINICAL HYPOTHYROIDISM
Yokota, T., Kuwahara, K., Murabe, H., & Murakami, N. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90782-8 · Cited by 2
Managing subclinical hypothyroidism
BMJ Publishing Group Ltd (1998) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.1998.3611 · Cited by 2
Giving thyroid hormones to clinically hypothyroid but biochemically euthyroid patients
Beckett, G. J., & Toft, A. D. (1997) · BMJ · doi:10.1136/bmj.315.7111.813 · Cited by 2
Disfunções músculo-esqueléticas em pacientes com hipotireoidismo subclínico
Reuters, V. S., Teixeira, P. D. F. D. S., de Castro, C. L. N., Almeida, C., Cardoso, H. R., Porciúncula, I. M., Nobre, T. H. S., Reis, F. A. A., Buescu, A., & Vaisman, M. (2003) · Acta Fisiátrica · doi:10.11606/issn.2317-0190.v10i1a102394 · Cited by 1
Role of Tissue Doppler Echocardiography in the Diagnosis of Subclinical Left and Right Ventricular Dysfunctions in Patients with Subclinical Hypothyroidism
Al-Afif, A. A., & Al-Sher, M. S. (2012) · Research Journal of Cardiology · doi:10.3923/rjc.2013.1.9 · Cited by 1
The Effect of Thyroxine Treatment in Infertile Subclinical Hypothyroid Patients
Sudek, H. L. (2011) · Journal of the Faculty of Medicine Baghdad · doi:10.32007/jfacmedbagdad.533845 · Cited by 1
Diagnosis and Treatment of Hypothyroidism
Ashraff, S., & Razvi, S. (2017) · Endocrinology · doi:10.1007/978-3-319-29195-6_14-1 · Cited by 1
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Psychiatric disorders and thyroid disease
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Treatment of anergic depression in hashimoto's thyroiditis with fluoxetine and d‐amphetamine
Cohen, A. J. (1993) · Depression · doi:10.1002/depr.3050010209 · Cited by 1
Historia natural del hipotiroidismo subclínico
Díez, J. J., & Iglesias, P. (2005) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(05)70997-9 · Cited by 1
Subclinical Thyroid Disease ScientificReviewandGuidelinesforDiagnosisandManagement
Surks, M. I., Ortíz, E., Daniels, G. H., Sawin, C. T., Col, N. F., Cobin, R. H., Franklyn, J. A., Hershman, J. M., Burman, K. D., Denke, M. A., et al. (2017) · Cited by 1
Doenças tireoidianas subclínicas e fatores de risco cardiovascular em mulheres com mais de 40 anos em seu local de trabalho
Olmos, R. D. (2007) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2007.tde-13022008-131920 · Cited by 1
Progression of Patients with a Borderline Raised Thyroid-Stimulating Hormone Concentration
BARRON, J. L., & Rough, B. (1996) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329603300212 · Cited by 1
Autoimmunthyreoiditis
Usadel, K.-H., & Schumm‐Draeger, P. ‐. (2003) · Der Internist · doi:10.1007/s00108-003-0875-y · Cited by 1
Thyroid screening in elderly hospital patients.
Byrne, E., Gilmore, D. H., & Beringer, T. R. O. (1988) · PubMed Central · Cited by 1
Thyroid Disorders
Cooper, D. S. (2006) · Springer eBooks · doi:10.1007/0-387-22621-4_48 · Cited by 1
Self-citation
Thyroid Disorders
Dong, B. J. (1992) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-13175-4_71 · Cited by 1
Thyroid Disorders
Cooper, D. S. (1990) · Springer eBooks · doi:10.1007/978-1-4757-2093-8_19 · Cited by 1
Self-citation
Thyroid Hormone Replacement Therapy for Primary and Secondary Hypothyroidism
Cooper, D. S. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-375-0_7
Self-citation
Mild Thyroid Deficiency in the Elderly
Pasqualetti, G., Dardano, A., Tognini, S., Polini, A., & Monzani, F. (2012) · InTech eBooks · doi:10.5772/48805
Estudo do perfil lipidico em uma população de mulheres gerontes, portadoras de hipotiroidismo subclinico
Peterson, J. C. B. (2007) · doi:10.47749/t/unicamp.2007.421261
Use of Myocardial Imaging to Identify and Manage Subclinical Heart Disease in Thyroid and Other Endocrine Diseases
Bello, V. D. (2007) · doi:10.1002/9780470692448.ch17
Weight Gain in Breast Cancer Patients on Chemotheraphy: Exploring Hormonal Body Composition and Behavioral Mechanisms
Kumar, N. B. (1999) · Defense Technical Information Center (DTIC)
Função tireóidea após lobectomia total por bócio não tóxico
de Carlucci, D. (2007) · doi:10.11606/t.5.2007.tde-02042007-141441
52 – Thyroid Diseases
Kopp, P. (2000) · Elsevier eBooks · doi:10.1016/b978-012288145-9/50061-9
Introduction: Clinical Aspects of Thyroid Treatment
Toft, A. D. (1997) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60709-7_1
Facets of Thyroid Disease in Women: Four Case Reports
Olson, B. R. (1998) · Journal of Women s Health · doi:10.1089/jwh.1998.7.85
Cardiovascular Manifestations of Thyroid Disease
Albrecht, C. R., & Gambert, S. R. (2002) · Heart Drug · doi:10.1159/000069666
More on Screening for Mild Thyroid Failure
Helfand, M. (1997) · JAMA · doi:10.1001/jama.1997.03540300026021
Thyroid Function in Older Persons
Bagchi, N., BROWN, T. R., & PARISH, R. F. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-5-718_2
Methodological problems in a study on the treatment of subclinical hypothyroidism
Goichot, B., Vinzio, S., & Schlienger, J. L. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01263-9
Inhibited 131I Uptake but Normal Release of Thyroid Hormone by Thyroid Gland in Response to TSH Administration in Subclinical Hypothyroidism
Kabadi, U. M. (2012) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2012.24015
Treatment With Thyroid Hormone-Reply
Cooper, D. S. (1989) · JAMA · doi:10.1001/jama.1989.03430130048028
Self-citation
¿Se debe instaurar tratamiento con tiroxina en los casos de hipotiroidismo subclínico?
Goñi, J. L. (2003) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/s1134-2072(03)75866-6
Impact of Thyroid Stimulating Hormone Level on Outcomes in Hypothyroid Patients With Acute Coronary Syndrome
Alla, V. M., Aronow, W. S., Kaushik, M., Reddy, Y. M., Kanuri, S., & Pavilion, M. (2011) · Open Journal of Cardiology
Evidence Based Medicine in Endocrinology
Rhee, S. Y., & Kim, Y. S. (2008) · Journal of Korean Endocrine Society · doi:10.3803/jkes.2008.23.6.379
SUB-CLINICAL HYPOTHYROIDISM: COMPLICATIONS AND EFFECTS OF THYROXINE THERAPY
Jadkar, S. P., Ganu, J. V., & Pujari, K. N. (2013)
Aus der Medizinischen Universitätsklinik und
Tübingen, P., & Medizin, A. I. (2005)
Effects of subclinical hypothyroidism treatment on psychiatric symptoms, muscular complaints, and quality of life Efeitos do tratamento do hipotiroidismo subclínico sobre sintomas psiquiátricos, queixas musculares e qualidade de vida
Almeida, C. D. P., Teixeira, S., Martins, M., de Castro, C. L. N., de Castro, N., Brasil, M. A. A., Buescu, A., Vaisman, M., Filho, F., & de Janeiro, R. (2012)
A Much-Needed Historic Perspective on the Therapeutic Use of Thyroid Hormones
Celi, F. S. (2015) · Endocrine Practice · doi:10.4158/ep15875.co
Disorders of the Thyroid
Miller, M. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6231-8.10090-x
PREVALENCIA DE HIPOTIROIDISMO EN PACIENTES MENOPÁUSICAS QUE ACUDEN AL HOSPITAL DE SAN GABRIEL, PROVINCIA DEL CARCHI
Sánchez, M. C. E., & Trajano, M. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Randomized Controlled Trial A With Levothyroxine Alone in Primary Hypothyroidism: Combined Levothyroxine Plus Liothyronine Compared
Lichten, E. M. (2009)
Small Changes in Thyroxine Dosage Do Not Produce Measurable Changes in Hypothyroid Symptoms, Well-Being, or Quality of Life: Results of a Double-Blind, Randomized Clinical Trial
Mazzaferri, E. L. (2007) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)70109-4
Changes of Body Composition, Blood Concentrations of Lipid Profiles and Thyroid Hormone After Exercise Training in Hypothyroid-induced Rat
Kim, K. (2012) · The Korean Journal of Obesity · doi:10.7570/kjo.2012.21.1.65
The Comparison of anxiety and stress between patients with hypothyroidism under regular medication regimen with normal group
Amiri, M., Jomhouri, R., Tavallaii, A., & Bejestani, H. S. (2016) · Health Research Journal · doi:10.20286/hrj-010123
Endocrinological Diseases Mimicking Affective Disorders
Extein, I., Gold, M. S., & Rafuls, W. A. (1989) · Springer eBooks · doi:10.1007/978-1-4612-3524-8_64
Screening For Hypothyroidism-Results Of A Study Conducted At District Headquarter Hospital, Abbottabad.
Gul, N., Farid, J., Idris, M., & Sarwar, J. (2016) · PubMed
Hypothyroidism
Tenpenny, S. (2009) · CRC Press eBooks · doi:10.1201/9781420067637.sec4
atualizacão Disfunções Mínimas da Tiróide: Hipotiroidismo Subclínico e Hipertiroidismo Subclínico
Romaldini, J. H., Sgarbi, J. A., & Farah, C. S. (2004)
Guías de práctica clínica para el tratamiento del hipotiroidismo
Brenta, G., Vaisman, M., Sgarbi, J. A., de Andrada, N. C., Bravo, P. P., Orlandi, A. M., & Graf, H. (2013)
Alternative Sequences of Thyrotropin and Free Thyroxine Assays for Routine Thyroid Function Testing
Nordyke, R. A., Reppun, T. S., Madanay, L. D., Woods, J. C., Goldstein, A. P., & Miyamoto, L. A. (2017)
A STUDY OF SYMPTOM SCORE AND LIPID PROFILE IN SUBCLINICAL HYPOTHYROIDISM BEFORE AND AFTER THYROXINE SUPPLEMENTATION
Sreenivasulu, P. P., Rani, A. S., & Pratap, B. (2015) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/2015/743
The Epidemiology and Management of Hypothyroidism in General Practice
Gibbons, V. (2011) · ResearchSpace (University of Auckland)
Compensated Autoimmune Adrenocortical Insufficiency
Feig, D. I., Williams, G. E., & Volpe, R. J. (1988) · Journal of the Royal Society of Medicine · doi:10.1177/014107688808100120
Hypothyroidism
Weber, K., & Haugen, B. R. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-4975-1.00043-7
Reply
Drinka, P. J., & Nolten, W. E. (1989) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198902000-00012
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Patterson, C. J. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.01.138
Subclinical Hypothyroidism: REFERENCES: EvidencE-based medicine: Relevant guidelines:
Ross, D. S. (2006)
Hypothyroidism
Weber, K., & Haugen, B. R. (2009) · Elsevier eBooks · doi:10.1016/b978-0-323-05885-8.00034-9
Subclinical hypothyroidism in community perspective: Treat or not to treat?
Kant, R., Barnwal, S., Yadav, P., Tendulkar, P., & Bairwa, M. C. (2021) · Journal of Preventive Medicine and Holistic Health · doi:10.18231/j.jpmhh.2021.005
Thyroid Dysfunction and Metabolism: Diagnosis and Follow-Up
Luzi, L., Massarini, S., Terruzzi, I., Ferrulli, A., & Cusini, C. (2021) · Springer eBooks · doi:10.1007/978-3-030-80267-7_11

Authors: COOPER, D. S., HALPERN, R., WOOD, L. C., LEVIN, A. A., & RIDGWAY, E. C.
Affiliations: Harvard University (US)
Boston, Massachusetts
Corresponding author: COOPER, DAVID S.
ORCID: COOPER, DAVID S.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 1984-07-01
Volume: 101
Issue: 1
Pages: 18-24
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-101-1-18
OpenAlex: W1976274614
Cited by: 423
References: 27
Citations by year: 2026: 1 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 11 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 19 · 2012: 17
FWCI: 9.48
Type: journal article
Language: en
Open access: closed
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords: subclinical hypothyroidism, L-thyroxine therapy, thyroid hormone replacement, thyroid-stimulating hormone, serum lipids, basal metabolic rate, systolic time intervals, cardiac contractility
MeSH terms: Adult, Aged, Double-Blind Method, Drug Evaluation, Female, Humans, Hypothyroidism, Male, Middle Aged, Myocardial Contraction, Prolactin, Random Allocation, Thyrotropin, Thyrotropin-Releasing Hormone, Thyroxine

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L-Thyroxine Therapy in Subclinical Hypothyroidism: A Double-Blind, Placebo-Controlled Trial

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