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Hepatitis B Vaccine in Health Care Personnel: Safety, lmmunogenicity, and Indicators of Efficacy
Abstract
In a double-blind trial, we randomly assigned 1330 high-risk health care personnel to receive three 20-micrograms doses of hepatitis B vaccine or placebo. Among vaccine recipients 58% responded within 1 month and 97% within 9 months; there was no difference in immune response to the vaccine between men and women. Efficacy was evaluated after a mean follow-up of only 13.2 months, just before the vaccine was released commercially. Five hepatitis B infections were identified in placebo recipients and one in a vaccine recipient. Although the number of infections was too small to allow confident conclusions about protective efficacy of the vaccine, we saw a 67% reduction in the need for hepatitis B immune globulin after accidental hepatitis B inoculation in the vaccine group (relative risk, 5.08; 95% confidence intervals, 1.3 to 19.9). Minor side effects occurred with equal frequency after vaccine (28.7%) and placebo (27.2%) injections; no participant had a severe adverse reaction. Vaccination with the 20-micrograms hepatitis B vaccine was highly immunogenic and safe in health care workers.
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Citations
Cited by
Long-Term Immunogenicity and Efficacy of Hepatitis B Vaccine in Homosexual Men
Hadler, S. C., Francis, D. P., Maynard, J. E., Thompson, S. E., Judson, F. N., Echenberg, D. F., Ostrow, D. G., O'Malley, P. M., Penley, K. A., Altman, N. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150401 · Cited by 608
Genetic Prediction of Nonresponse to Hepatitis B Vaccine
Alper, C. A., Kruskall, M. S., Marcus-Bagley, D., Craven, D. E., Katz, A. J., Brink, S. J., Dienstag, J. L., Awdeh, Z., & Yunis, E. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909143211103 · Cited by 401
Self-citationObesity as a Predictor of Poor Antibody Response to Hepatitis B Plasma Vaccine
Weber, D. J. (1985) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1985.03360220053027 · Cited by 345
Metadata
- Authors
- DIENSTAG, J. L., WERNER, B. G., POLK, B. F., SNYDMAN, D. R., CRAVEN, D. E., PLATT, R., CRUMPACKER, C. S., OUELLET-HELLSTROM, R., & GRADY, G. F.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1984-07-01
- Volume
- 101
- Issue
- 1
- Pages
- 34-40
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2064577032
- Cited by
- 193
- References
- 0
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hepatitis B Vaccine in Health Care Personnel: Safety, lmmunogenicity, and Indicators of Efficacy. https://app.cochat.ai/papers/10.7326/0003-4819-101-1-34
- The paper
- DIENSTAG, J. L., WERNER, B. G., POLK, B. F., SNYDMAN, D. R., CRAVEN, D. E., PLATT, R., CRUMPACKER, C. S., OUELLET-HELLSTROM, R., & GRADY, G. F. (1984). Hepatitis B Vaccine in Health Care Personnel: Safety, lmmunogenicity, and Indicators of Efficacy. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-101-1-34
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
