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Cited by 188Obstructive Sleep Apnea ResearchThyroid Disorders and TreatmentsNeuroscience of respiration and sleep

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Obstructive Sleep Apnea in Hypothyroidism

RAJAGOPAL, KRISHNAN R., ABBRECHT, PETER H., DERDERIAN, SARKIS S., PICKETT, CHERYL, HOFELDT, FRED, TELLIS, CLAUDE J., ZWILLICH, CLIFFORD W.·1984·Annals of Internal Medicine
DOI 10.7326/0003-4819-101-4-491
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Abstract

To determine the incidence and frequency of sleep apnea in persons with hypothyroidism, 11 consecutive patients with newly diagnosed disease were studied before and during thyroid hormone replacement therapy. Nine patients had episodes of apnea, with the number of episodes per hour of sleep ranging from 17 to 176 (mean, 71.8). Six of the nine patients were obese and had 99.5 episodes per hour compared with 16.3 episodes per hour in the 3 nonobese patients (p less than 0.02). After 3 to 12 months of thyroxine replacement therapy, mean apnea frequency decreased from 71.8 +/- 18.0 (SE) to 12.7 +/- 6.1 episodes per hour, without reduction in body weight. There were fewer changes in sleep stage per hour during treatment (22.1 +/- 4.9) than pretreatment (57.6 +/- 14.5). Carbon dioxide response tests done under non-loaded and flow-resistive loaded conditions before and during thyroxine replacement therapy showed increases in the loaded respiratory effort and ventilation during thyroxine treatment. Sleep apnea episodes are common in persons with untreated hypothyroidism, even with normal lung function. Thyroxine replacement therapy decreases apnea frequency, even without change in body weight.

Overview

Integrity signals

Registry

Crossref · 10.7326/0003-4819-101-4-491

Cites

16 of 16 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 5

  1. GUILLEMINAULT C, 1978, Conference on Sleep Apnea Syndromes., 1
  2. RECHTSHAFFEN A, 1968, A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.
  3. WINER B . Statistical Principles in Experimental Design. New York: McGraw Hill Book Co.; 1971:514-603.
  4. LOPATA M, 1982, Am Rev Respir Dis., 126, 640
  5. MCNICHOLAS W, 1984, Am Rev Respir Dis., 129, 45

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Metadata

Authors
RAJAGOPAL, K. R., ABBRECHT, P. H., DERDERIAN, S. S., PICKETT, C., HOFELDT, F., TELLIS, C. J., & ZWILLICH, C. W.
Affiliations
Washington, D.C.; Bethesda, Maryland; and Denver, Colorado
Corresponding author
RAJAGOPAL, KRISHNAN R.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1984-10-01
Volume
101
Issue
4
Pages
491-494
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-101-4-491
OpenAlex
W2012436441
Cited by
188
References
16
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 6
FWCI
4.80
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
obstructive sleep apnea, hypothyroidism, thyroxine replacement, apnea frequency, obesity, sleep stages, thyroid hormone replacement
MeSH terms
Adult, Humans, Hypothyroidism, Middle Aged, Obesity, Respiratory Function Tests, Sleep Apnea Syndromes, Sleep Stages, Thyroxine

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