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Cited by 167Obstructive Sleep Apnea ResearchThyroid Disorders and TreatmentsNeuroscience of respiration and sleep

The Relationship between Sleep Apnea Syndrome and Hypothyroidism

Lin, Ching-Chi, Tsan, Kun-Wu, Chen, Pei-Jan·1992·Chest
DOI 10.1378/chest.102.6.1663
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Abstract

To evaluate the prevalence of obstructive sleep apnea syndrome (OSAS) in patients with hypothyroidism, the prevalence of hypothyroidism in patients with OSAS, the possible factors predisposing to sleep-related breathing disorder in hypothyroid patients, and the effect of thyroid hormone in treating hypothyroidism associated with OSAS, we studied 65 patients with proven OSAS (apnea index [AI] > 5) and 20 hypothyroid patients. All patients were monitored for one overnight sleep study using polysomnography (Grass 78). We found only two (3.1 percent) of 65 OSAS patients had thyroid hypofunction. Of 20 patients with hypothyroidism, two showed moderate to severe OSAS and three had mild OSAS. Patients with both hypothyroidism and OSAS had impaired respiratory drive, but this was corrected by thyroid hormone therapy. Patients with hypothyroidism without OSAS were younger and had a lower percentage of ideal body weight than those with both hypothyroidism and OSAS. All hypothyroid patients were snorers. Thyroid hormone replacement was effective in correcting snoring only after one year of therapy. We conclude the following: (1) an overnight sleep study is not necessary in every case of hypothyroidism; (2) thyroid function studies need not be done routinely for every OSAS patient; (3) thyroid hormone therapy is effective for OSAS but it takes longer to correct the snore than respiratory drive; and (4) age and body weight are related to the development of OSAS.

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Crossref · 10.1378/chest.102.6.1663

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24 of 24 references verified0 citation errors · 0 not checkable

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  • A link between hypothyroidism and OSAS is suggested by the high prevalence of sleep apnea among hypothyroid patients, particularly in rare myxedematous cases.

    “A link between hypothyroidism and OSAS is suggested by the high prevalence of sleep apnea among hypothyroid patients, particularly in rare myxedematous cases [3,7].”

    From Sleep apnea syndrome and hypothyroidism (2013) · cites this paper as [7]

  • Both Lin et al. and Kittle and Chaudhary reported that some patients did not have improvements in their sleep experience with thyroid hormone replacement therapy.

    “However, both studies reported that some patients did not have improvements in their sleep experience with thyroid hormone replacement therapy.”

    From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [15]

  • Lin et al. showed that T4 replacement therapy improved symptoms of OSA for some patients.

    “Lin et al. (15) showed that T4 replacement therapy improved symptoms of OSA for some patients.”

    From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [15]

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Authors
Lin, C.-C., Tsan, K.-W., & Chen, P.-J.
Affiliations
Mackay Memorial Hospital (TW)
Corresponding author
Lin, Ching-Chi
ORCID
Lin, Ching-Chi
Venue
Chest
Publisher
Elsevier BV
Published
1992-12
Volume
102
Issue
6
Pages
1663-1667
ISSN
0012-3692 (ISSN-L)
DOI
10.1378/chest.102.6.1663
OpenAlex
W2060091831
Cited by
167
References
24
Citations by year
2026: 4 · 2025: 5 · 2024: 25 · 2023: 8 · 2022: 8 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 15 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 5
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • CHEST Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
obstructive sleep apnea, hypothyroidism, thyroid hormone replacement, snoring, respiratory drive, apnea index, body weight, age, sleep-disordered breathing, polysomnography
MeSH terms
Adult, Age Factors, Arousal, Body Weight, Female, Humans, Hypothyroidism, Male, Middle Aged, Movement, Oxygen, Respiration, Risk Factors, Sleep Apnea Syndromes, Snoring, Thyroid Hormones, Thyrotropin, Prevalence

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