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Treatment of Diabetic Diarrhea with Clonidine
Abstract
Stimulation of alpha 2-adrenergic receptors on enterocytes promotes fluid and electrolyte absorption and inhibits anion secretion. Loss of adrenergic innervation may play a role in impaired intestinal fluid and electrolyte absorption in diabetic patients with autonomic neuropathy. Clonidine, an alpha 2-adrenergic agonist, was used to treat three patients with "idiopathic" diabetic diarrhea after other treatments had failed: The volume of diarrhea declined significantly (p less than 0.01). Diarrhea recurred when the drug was withdrawn, but the patient's condition improved again when clonidine treatment was reintroduced. Hypotension did not occur as a side effect presumably because of the autonomic neuropathy of these patients.
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Citations
Cited by
Vinik, A. I., Maser, R. E., Mitchell, B. D., & Freeman, R. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1553 · Cited by 2,044
Long-Term Complications of Diabetes Mellitus
Nathan, D. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306103282306 · Cited by 1,495
Diretrizes Brasileiras de Hipertensão Arterial – 2020
Barroso, W. K. S., Rodrigues, C. I. S., Bortolotto, L. A., Mota-Gomes, M. A., Brandão, A. A., Feitosa, A. D. D. M., Machado, C. A., Poli-de-Figueiredo, C. E., Amodeo, C., Mion, D., et al. (2021) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20201238 · Cited by 1,068
Autonomic neuropathy: its diagnosis and prognosis
Ewing, D. J., & Clarke, B. F. (1986) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(86)80078-0 · Cited by 259
Adrenergic modulation of human colonic motor and sensory function
Bharucha, A. E., Camilleri, M., Zinsmeister, A. R., & Hanson, R. B. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.5.g997 · Cited by 177
Metadata
- Authors
- FEDORAK, R. N., FIELD, M., & CHANG, E. B.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1985-02-01
- Volume
- 102
- Issue
- 2
- Pages
- 197-199
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2089378788
- Cited by
- 195
- References
- 0
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- FEDORAK, R. N., FIELD, M., & CHANG, E. B. (1985). Treatment of Diabetic Diarrhea with Clonidine. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-102-2-197
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
