Adrenergic modulation of human colonic motor and sensory function

The Hospital Anxiety and Depression Scale

Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works

Altered rectal perception is a biological marker of patients with irritable bowel syndrome

Mertz, H., Naliboff, B. D., Munakata, J., Niazi, N., & Mayer, E. A. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90267-8 · Cited by 976 · see citing works

Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents

Unnerstall, J. R., Kopajtic, T. A., & Kuhar, M. J. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90030-4 · Cited by 708 · see citing works

Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor.

Goldberg, M. R., & Robertson, D. (1983) · PubMed · Cited by 438 · see citing works

Assessment of Functional Gastrointestinal Disease: The Bowel Disease Questionnaire

TALLEY, N. J., PHILLIPS, S. F., WILTGEN, C. M., ZINSMEISTER, A. R., & MELTON, L. J. (1990) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62169-7 · Cited by 330 · see citing works

Motility of the pelvic colon

Connell, A. M., Jones, F. A., & Rowlands, E. N. (1965) · Gut · doi:10.1136/gut.6.2.105 · Cited by 211 · see citing works

Treatment of Diabetic Diarrhea with Clonidine

Fedorak, R. N., FIELD, M., & CHANG, E. B. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-102-2-197 · Cited by 199 · see citing works

Gastric tone determines the sensitivity of the stomach to distention

Notivol, R., Coffin, B., Azpiroz, F., Mearin, F., Serra, J., & Malagelada, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90057-8 · Cited by 175 · see citing works

The gastrocolic response: Evidence for a neural mechanism

Snape, W. J., Wright, S., Battle, W. M., & Cohen, S. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90162-8 · Cited by 170 · see citing works

A double-blind controlled trial of oral-pulse methotrexate therapy in the treatment of primary sclerosing cholangitis

Knox, T. A., & Kaplan, M. M. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90610-6 · Cited by 169 · see citing works

Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon

Ford, M. J., Camilleri, M., Zinsmeister, A. R., & Hanson, R. B. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90743-2 · Cited by 167 · see citing works

Clonidine-Induced Analgesia in Postoperative Patients

Bonnet, F. J., Boico, O., Rostaing, S., Loriferne, J.-F., & Saada, M. (1990) · Anesthesiology · doi:10.1097/00000542-199003000-00004 · Cited by 155 · see citing works

Variation of muscle tone in the human colon.

Steadman, C., Phillips, S. F., Camilleri, M., Haddad, A. C., & Hanson, R. B. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90014-c · Cited by 136 · see citing works

Differences in colonic tone and phasic response to a meal in the transverse and sigmoid human colon.

Ford, M. J., Camilleri, M., Wiste, J. A., & Hanson, R. B. (1995) · Gut · doi:10.1136/gut.37.2.264 · Cited by 126 · see citing works

Role of alpha-2 adrenergic receptors in the control of diarrhea and intestinal motility.

Doherty, N. S., & Hancock, A. A. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33584-6 · Cited by 101 · see citing works

Effects of the somatostatin analogue octreotide on rectal afferent nerves in humans

Plourde, V., Lembo, T., Shui, Z., Parker, J., Mertz, H., Taché, Y., Sytnik, B., & Mayer, E. A. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.265.4.g742 · Cited by 91 · see citing works

Adynamic ileus, its pathogenesis and treatment.

Furness, J. B., & Costa, M. (1974) · PubMed · Cited by 90 · see citing works

Studies of the antidiarrheal action of clonidine

Schiller, L. R., Ana, C. A. S., Morawski, S. G., & Fordtran, J. S. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90197-0 · Cited by 84 · see citing works

Narcotic Bowel Syndrome Treated with Clonidine

SANDGREN, J. E., McPHEE, M. S., & GREENBERGER, N. J. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-3-331 · Cited by 67 · see citing works

Inhibitory control of proximal colonic motility by the sympathetic nervous system

Gillis, R. A., Souza, J., Hicks, K. A., Mangel, A. W., Pagani, F. D., Hamilton, B. L., Garvey, T. Q., Pace, D. G., Browne, R., & Norman, W. P. (1987) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1987.253.4.g531 · Cited by 65 · see citing works

Possible Structural and Functional Relationships between Imidazoline Receptors and α2‐Adrenoceptors

Hieble, J. P., & Ruffolo, R. R., Jr. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb32387.x · Cited by 61 · see citing works

Effect of stress, meal and neostigmine on rectosigmoid electrical control activity (ECA) in normals and in irritable bowel syndrome patients

Sarna, S. K., Latimer, P. R., Campbell, D., & Waterfall, W. E. (1982) · Digestive Diseases and Sciences · doi:10.1007/bf01297213 · Cited by 58 · see citing works

Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers

Hedner, T., Edgar, B., Edvinsson, L. I., Hedner, J. A., Persson, B., & Pettersson, A. F. (1992) · European Journal of Clinical Pharmacology · doi:10.1007/bf02284967 · Cited by 53 · see citing works

Effects of beta-adrenoceptor blocking drugs on human sigmoid colonic motility

Abrahamsson, H., Lyren�s, E., & Dotevall, G. (1983) · Digestive Diseases and Sciences · doi:10.1007/bf01299918 · Cited by 43 · see citing works

Sympathetic reactivity during a yohimbine challenge test in essential hypertension.

Goldstein, D. S., Grossman, E., LISTWAK, S. J., & Folio, C. J. (1991) · Hypertension · doi:10.1161/01.hyp.18.5_suppl.iii40 · Cited by 43 · see citing works

Relaxation responses of the human proximal stomach to distension during fasting and after food

Ahluwalia, N., Thompson, D. G., Barlow, J. D., Troncon, L. E. D. A., & Hollis, S. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.2.g166 · Cited by 38 · see citing works

Characterization of the β-adrenergic inhibition of motility in cat colon strips

Ek, B. A., & Lundgren, B. (1982) · European Journal of Pharmacology · doi:10.1016/0014-2999(82)90530-1 · Cited by 35 · see citing works

Vagal influence on colonic motor activity in conscious nonhuman primates

Dapoigny, M. C., Cowles, V. E., Zhu, Y.-R., & Condon, R. E. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.262.2.g231 · Cited by 34 · see citing works

Suppression of small intestinal motility and morphine withdrawal diarrhoea by clonidine: peripheral site of action

Thollander, M. S., Hellström, P. M., & Svensson, T. H. (1989) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1989.tb08768.x · Cited by 25 · see citing works

Hyperventilation alters colonic motor and sensory function: Effects and mechanisms in humans

Bharucha, A., Camilleri, M., Mj, F., Mk, O., Hanson, R. B., & Thomforde, G. M. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690201 · Cited by 25 · see citing works

Mechanism of Sympathoinhibition by Imidazolines

Szabó, B., & Urban, R. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb32449.x · Cited by 17 · see citing works

Selective adrenergic agonists and colon motility in monkeys.

Salaymeh, B., Ve, C., Tekin, E., Yr, Z., Bj, B., & Re, C. (1992) · PubMed · Cited by 17 · see citing works

Demonstration of intrathecal and systemic morphine and ST-91 effects on fed canine upper gut motility

Thomforde, G. M., Malagelada, J., Camilleri, M., & Yaksh, T. L. (1990) · Digestive Diseases and Sciences · doi:10.1007/bf01536415 · Cited by 11 · see citing works

Basic and Clinical aspects of chronic abdominal pain

Hammer, H. F. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90480-8 · Cited by 5 · see citing works

AGA technical review on irritable bowel syndrome.

Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works

Interactions between the cardiovascular and pain regulatory systems: an updated review of mechanisms and possible alterations in chronic pain

Bruehl, S. P., & Chung, O. Y. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.06.004 · Cited by 377 · see citing works

Management of the irritable bowel syndrome

Camilleri, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.21908 · Cited by 344 · see citing works

Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress

Posserud, I., Agerforz, P., Ekman, R., Björnsson, E. S., Abrahamsson, H., & Simrén, M. (2004) · Gut · doi:10.1136/gut.2003.017962 · Cited by 292 · see citing works

American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice

Camilleri, M., Bharucha, A. E., Lorenzo, C. D., Hasler, W. L., Prather, C. M., Rao, S. S. C., & Wald, A. M. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01230.x · Cited by 255 · see citing works

Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome

Camilleri, M., McKinzie, S., Busciglio, I. A., Low, P. A., Sweetser, S. R., Burton, D. D., Baxter, K. L., Ryks, M. D., & Zinsmeister, A. R. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.02.060 · Cited by 242 · see citing works

G-protein β3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia 1 ☆

Holtmann, G., Siffert, W., Haag, S., Mueller, N., Langkafel, M., Senf, W., Zotz, R. B., & Talley, N. J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.006 · Cited by 213 · see citing works

Stress and visceral pain: From animal models to clinical therapies

Larauche, M. H., Mulak, A., & Taché, Y. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.04.020 · Cited by 212 · see citing works

Visceral hypersensitivity: facts, speculations, and challenges

Camilleri, M., COULIE, B., & Tack, J. F. (2001) · Gut · doi:10.1136/gut.48.1.125 · Cited by 204 · see citing works

The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: A double blind, randomized, placebo-controlled study

Kuiken, S. D., Tytgat, G. N. J., & Boeckxstaens, G. E. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70039-1 · Cited by 206 · see citing works

Modulation of gastric sensory and motor functions by nitrergic and α2-adrenergic agents in humans

Thumshirn, M., Camilleri, M., Choi, M., & Zinsmeister, A. R. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70179-4 · Cited by 186 · see citing works

Association of distinct α2 adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders

Kim, H. J., Camilleri, M., Carlson, P., Cremonini, F., Ferber, I., Stephens, D., Mckinzie, S., Zinsmeister, A., & Urrutia, R. (2004) · Gut · doi:10.1136/gut.2003.030882 · Cited by 168 · see citing works

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P. G., Lorenzo, C. D., Huizinga, J. D., Jiménez, M., Rao, S. S. C., et al. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0167-1 · Cited by 161 · see citing works

The β3-adrenoceptor as a therapeutic target: Current perspectives

Ursino, M. G., Vasina, V. I., Raschi, E., Crema, F., & Ponti, F. D. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.01.002 · Cited by 156 · see citing works

Cholinergic stimulation enhances colonic motor activity, transit, and sensation in humans

Law, N., Bharucha, A. E., Undale, A. S., & Zinsmeister, A. R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.5.g1228 · Cited by 147 · see citing works

Insights into the Pathophysiology and Mechanisms of Constipation, Irritable Bowel Syndrome, and Diverticulosis in Older People

Camilleri, M., Lee, J. S., Viramontes, B. E., Bharucha, A. E., & Tangalos, E. G. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04793.x · Cited by 144 · see citing works

Review article: modulation of the brain–gut axis as a therapeutic approach in gastrointestinal disease

Mayer, E. A., Tillisch, K., & Bradesi, S. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03078.x · Cited by 139 · see citing works

Consensus report: clinical perspectives, mechanisms, diagnosis and management of irritable bowel syndrome

Camilleri, M., Heading, R. C., & Thompson, W. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01305.x · Cited by 134 · see citing works

Effects of glucagon-like peptide-1(7–36)amide on motility and sensation of the proximal stomach in humans

Schirra, J., Wank, U., Arnold, R., Göke, B., & Katschinski, M. (2002) · Gut · doi:10.1136/gut.50.3.341 · Cited by 130 · see citing works

Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention

Tack, J. F., Caenepeel, P., Corsetti, M., & Janssens, J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.07.005 · Cited by 129 · see citing works

High amplitude propagated contractions

Bharucha, A. E. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12019 · Cited by 119 · see citing works

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome

Camilleri, M., & Katzka, D. A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00537.2011 · Cited by 115 · see citing works

Topical phenylephrine increases anal canal resting pressure in patients with faecal incontinence

Cheetham, M., Kamm, M. A., & Phillips, R. K. S. (2001) · Gut · doi:10.1136/gut.48.3.356 · Cited by 113 · see citing works

Treatment With Hypnotherapy Reduces the Sensory and Motor Component of the Gastrocolonic Response in Irritable Bowel Syndrome

Simrén, M., Ringström, G., Björnsson, E. S., & Abrahamsson, H. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000116964.76529.6e · Cited by 111 · see citing works

Effects of a cannabinoid receptor agonist on colonic motor and sensory functions in humans: a randomized, placebo-controlled study

Esfandyari, T., Camilleri, M., Busciglio, I. A., Burton, D. D., Baxter, K. L., & Zinsmeister, A. R. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00565.2006 · Cited by 111 · see citing works

A Study of Candidate Genotypes Associated with Dyspepsia in a U.S. Community

Camilleri, C. E., Carlson, P. J., Camilleri, M., Castillo, E. J., Locke, G. R., Geno, D. M., Stephens, D. A., Zinsmeister, A. R., & Urrutia, R. A. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00481.x · Cited by 107 · see citing works

Effects of a κ-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans

Delgado-Aros, S., Chial, H. J., Camilleri, M., Szarka, L. A., Weber, F. T., Jacob, J., Ferber, I. J., McKinzie, S., Burton, D. D., & Zinsmeister, A. R. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00360.2002 · Cited by 108 · see citing works

Manometric, Sensorimotor, and Neurophysiologic Evaluation of Anorectal Function

Scott, S. M., & Gladman, M. A. (2008) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2008.06.010 · Cited by 103 · see citing works

Manometric techniques for the evaluation of colonic motor activity: current status

Scott, S. M. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00434.x · Cited by 100 · see citing works

Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients With Nonconstipated Irritable Bowel Syndrome

Wong, B. S., Camilleri, M., Busciglio, I., Carlson, P., Szarka, L. A., Burton, D., & Zinsmeister, A. R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.036 · Cited by 100 · see citing works

Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans

Bharucha, A. E., Charkoudian, N., Andrews, C. N., Camilleri, M., Sletten, D., Zinsmeister, A. R., & Low, P. A. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00153.2008 · Cited by 98 · see citing works

Phenotypic Variation of Colonic Motor Functions in Chronic Constipation

Ravi, K., Bharucha, A. E., Camilleri, M., Rhoten, D., Bakken, T., & Zinsmeister, A. R. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.07.057 · Cited by 92 · see citing works

Surgical autonomic denervation results in altered colonic motility: an explanation for low anterior resection syndrome?

Lee, W. Y., Takahashi, T., Pappas, T. N., Mantyh, C. R., & Ludwig, K. A. (2008) · Surgery · doi:10.1016/j.surg.2008.03.014 · Cited by 94 · see citing works

Effects of an α2-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans

Viramontes, B. E., Malcolm, A., Camilleri, M., Szarka, L. A., McKinzie, S., Burton, D. D., & Zinsmeister, A. R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.6.g1468 · Cited by 93 · see citing works

A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome

Camilleri, M., Kim, D.-Y., McKinzie, S., Kim, H. J., Thomforde, G. M., Burton, D. D., Low, P. A., & Zinsmeister, A. R. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1053/cgh.2003.50019 · Cited by 90 · see citing works

Effects of a serotonin 5-HT 4 receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans

Bharucha, A. E., Camilleri, M., Haydock, S., Ferber, I., Burton, D., Cooper, S., Tompson, D., Fitzpatrick, K., Higgins, R., & Zinsmeister, A. R. (2000) · Gut · doi:10.1136/gut.47.5.667 · Cited by 90 · see citing works

Irritable bowel syndrome

Talley, N. J. (2006) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2006.01217.x · Cited by 86 · see citing works

Review article: colonic sensorimotor physiology in health, and its alteration in constipation and diarrhoeal disorders

Camilleri, & Ford (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00305.x · Cited by 85 · see citing works

Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans

Chial, H. J., Camilleri, M., Ferber, I. J., Delgado-Aros, S., Burton, D. D., McKinzie, S., & Zinsmeister, A. R. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70038-x · Cited by 84 · see citing works

Rectal visceral sensitivity in healthy volunteers: influences of gender, age and methods

Sloots, Felt-Bersma, R. J. F., Cuesta, & Meuwissen, S. G. M. (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00210.x · Cited by 80 · see citing works

Colonic Migrating Motor Complexes, High Amplitude Propagating Contractions, Neural Reflexes and the Importance of Neuronal and Mucosal Serotonin

Smith, T., Park, K., & Hennig, G. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14092 · Cited by 113 · see citing works

Barostat testing of rectal sensation and compliance in humans: comparison of results across two centres and overall reproducibility

Cremonini, F., Houghton, L., Camilleri, M., Ferber, I., Fell, C., Cox, V., Castillo, E. J., Alpers, D., Dewit, O., Gray, E., et al. (2005) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2005.00709.x · Cited by 93 · see citing works

Baroreflex sensitivity associated hypoalgesia in healthy states is altered by chronic pain

Chung, O. Y., Bruehl, S. P., Diedrich, L., Diedrich, A., Chont, M., & Robertson, D. (2008) · Pain · doi:10.1016/j.pain.2007.11.011 · Cited by 76 · see citing works

Irritable Bowel Syndrome

Andresen, V., & Camilleri, M. (2006) · Drugs · doi:10.2165/00003495-200666080-00004 · Cited by 77 · see citing works

High body mass alters colonic sensory-motor function and transit in humans

Delgado-Aros, S., Camilleri, M., Garcia, M. A., Burton, D. D., & Busciglio, I. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90286.2008 · Cited by 73 · see citing works

Towards identifying optimal doses for alpha‐2 adrenergic modulation of colonic and rectal motor and sensory function

Malcolm, A., Camilleri, Kost, Burton, Fett, & Zinsmeister, A. R. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00757.x · Cited by 71 · see citing works

Day‐to‐day reproducibility of anorectal sensorimotor assessments in healthy subjects

Bharucha, A. E., Seide, B. M., Fox, J. C., & Zinsmeister, A. R. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00499.x · Cited by 68 · see citing works

The Role of the Barostat in Human Research and Clinical Practice

P. J. van der Schaar, C. B. H. W. L. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750025552 · Cited by 67 · see citing works

Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity

Bueno, L., De Ponti, F., Fried, M., Kullak‐ublick, G. A., Kwiatek, M. A., Pohl, D., Quigley, E. M. M., Tack, J., & Talley, N. J. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00876.x · Cited by 64 · see citing works

Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits

Camilleri, M., Kolar, G. J., Vázquez‐Roque, M. I., Carlson, P., Burton, D. D., & Zinsmeister, A. R. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00376.2012 · Cited by 64 · see citing works

Candidate genes and sensory functions in health and irritable bowel syndrome.

Camilleri, M., Busciglio, I., Carlson, P., Mckinzie, S., Burton, D., Baxter, K., Ryks, M., & Zinsmeister, A. (2008) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90202.2008 · Cited by 68 · see citing works

Common Functional Gastroenterologic Disorders Associated With Abdominal Pain

Bharucha, A., Chakraborty, S., & Sletten, C. (2016) · Mayo Clinic proceedings · doi:10.1016/j.mayocp.2016.06.003 · Cited by 56 · see citing works

Effects of pregabalin on visceral pain responses and colonic compliance in rats

Ravnefjord, A., Brusberg, M., Larsson, H., Lindström, E., & Martı́nez, V. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.259 · Cited by 64 · see citing works

Updates on treatment of irritable bowel syndrome

Hammerle, C. W., & Surawicz, C. M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2639 · Cited by 64 · see citing works

Treating irritable bowel syndrome: overview, perspective and future therapies

Camilleri, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705741 · Cited by 64 · see citing works

Testing the sensitivity hypothesis in practice: tools and methods, assumptions and pitfalls

Camilleri, M. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i34 · Cited by 62 · see citing works

Measurement of Gastrointestinal and Colonic Motor Functions in Humans and Animals

Camilleri, M., & Linden, D. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.04.003 · Cited by 55 · see citing works

Viscoelastic properties of the human colon

Bharucha, A. E., Hubmayr, R. D., Ferber, I. J., & Zinsmeister, A. R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.2.g459 · Cited by 60 · see citing works

Serotonergic modulating drugs for functional gastrointestinal diseases

Spiller, R. E. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01612.x · Cited by 60 · see citing works

Gastric electrical stimulation at proximal stomach induces gastric relaxation in dogs

Xing, J. H., Brody, F. J., Brodsky, J. A., Larive, B., Ponsky, J. L., & Soffer, E. E. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00385.x · Cited by 60 · see citing works

Visceral Hypersensitivity

Delgado-Aros, S., & Camilleri, M. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000156114.22598.1b · Cited by 57 · see citing works

Rectal and colonic distension elicit viscerovisceral reflexes in humans

Law, N., Bharucha, A. E., & Zinsmeister, A. R. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00359.2001 · Cited by 56 · see citing works

Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome

Thumshirn, Coulie, Camilleri, Zinsmeister, Burton, & Dyke, V. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00786.x · Cited by 55 · see citing works

Irritable pouch syndrome is characterized by visceral hypersensitivity

Shen, B., Sanmiguel, C. P., Bennett, A. E., Lian, L., Larive, B., Remzi, F. H., Fazio, V. W., & Soffer, E. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21412 · Cited by 52 · see citing works

Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor

Smith, C. R., Nordstrom, E. M., Sengupta, J. N., & Miranda, A. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00949.x · Cited by 52 · see citing works

Effects of Clonidine in Women With Fecal Incontinence

Bharucha, A. E., Fletcher, J. G., Camilleri, M., Edge, J., Carlson, P., & Zinsmeister, A. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.06.035 · Cited by 50 · see citing works

Current and novel therapeutic options for irritable bowel syndrome management

Camilleri, M., & Andresen, V. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.009 · Cited by 48 · see citing works

Coloanal motor coordination in association with high-amplitude colonic contractions after pharmacological stimulation

Malcolm, A., & Camilleri, M. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01840.x · Cited by 48 · see citing works

Rectal sensorimotor dysfunction in women with fecal incontinence

Andrews, C. N., Bharucha, A. E., Seide, B., & Zinsmeister, A. R. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00176.2006 · Cited by 48 · see citing works

Effect of the NK3 receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans

Houghton, L. A., Cremonini, F., Camilleri, M., Busciglio, I., Fell, C., Cox, V., Alpers, D. H., Dewit, O., Dukes, G. E., Gray, E., et al. (2007) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2007.00934.x · Cited by 46 · see citing works

Mechanisms of Disease: genetics of functional gastrointestinal disorders—searching the genes that matter

Adam, B., Liebregts, T., & Holtmann, G. (2007) · Nature Clinical Practice Gastroenterology &#38 Hepatology · doi:10.1038/ncpgasthep0717 · Cited by 44 · see citing works

The relationship between resting blood pressure and acute pain sensitivity: effects of chronic pain and alpha-2 adrenergic blockade

Bruehl, S. P., Chung, O. Y., Diedrich, L., Diedrich, A., & Robertson, D. (2007) · Journal of Behavioral Medicine · doi:10.1007/s10865-007-9133-4 · Cited by 44 · see citing works

Clinical effects and pharmacokinetic variables of romifidine and the peripheral α2‐adrenoceptor antagonist MK‐467 in horses

de Vries, A., Pakkanen, S. A., Raekallio, M. R., Ekiri, A. B., Scheinin, M., Taylor, P. M., & Vainio, O. (2016) · Veterinary Anaesthesia and Analgesia · doi:10.1111/vaa.12354 · Cited by 43 · see citing works

Enteric alpha-2 adrenoceptors: Pathophysiological implications in functional and inflammatory bowel disorders

Blandizzi, C. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.05.013 · Cited by 43 · see citing works

Pharmacological and Pharmacokinetic Aspects of Functional Gastrointestinal Disorders

Camilleri, M., Bueno, L. P., Ponti, F. D., Fioramonti, J., Lydiard, R. B., & Tack, J. F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.062 · Cited by 42 · see citing works

Barostat Measurement of Rectal Compliance and Capacity

Fox, M. R., Thumshirn, M., Fried, M., & Schwizer, W. (2006) · Diseases of the Colon & Rectum · doi:10.1007/s10350-005-0295-2 · Cited by 41 · see citing works

Meal induced rectosigmoid tone modification: a low caloric meal accurately separates functional and organic gastrointestinal disease patients

Stefano, M. D., Miceli, E., Missanelli, A., Mazzocchi, S., & Corazza, G. R. (2006) · Gut · doi:10.1136/gut.2005.076323 · Cited by 41 · see citing works

Drug Development for the Irritable Bowel Syndrome: Current Challenges and Future Perspectives

Ponti, F. D. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00007 · Cited by 40 · see citing works

Review article: drugs interfering with visceral sensitivity for the treatment of functional gastrointestinal disorders – the clinical evidence

Kuiken, S. D., Tytgat, G. N. J., & Boeckxstaens, G. E. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02392.x · Cited by 40 · see citing works

The Antinociceptive Effects of Intravenous Dexmedetomidine in Colorectal Distension-Induced Visceral Pain in Rats: The Role of Opioid Receptors

Ülger, F., Bozkurt, A., Bilge, S. S., İlkaya, F., Dilek, A., Bostanci, M. Ö., Çıftçıoğlu, E., & Güldoğuş, F. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181a9fae2 · Cited by 38 · see citing works

Changes in brain G proteins and colonic sympathetic neural signaling in chronic-acute combined stress rat model of irritable bowel syndrome (IBS)

Zou, N., Lv, H., Li, J., Yang, N., Xue, H., Zhu, J., & Qian, J. (2008) · Translational research · doi:10.1016/j.trsl.2008.10.002 · Cited by 38 · see citing works

An exploratory study of the association of adrenergic and serotonergic genotype and gastrointestinal motor functions

Grudell, A., Camilleri, M., Carlson, P., Gorman, H., Ryks, M. D., Burton, D. D., Baxter, K. L., & Zinsmeister, A. R. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.01026.x · Cited by 36 · see citing works

Megacolon: Acute, toxic, and chronic

Bharucha, A. E., & Phillips, S. F. (1999) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-999-0055-9 · Cited by 35 · see citing works

Colonic Motor Function in Humans Is Not Affected by Gender

Soffer, E., Kongara, K. R., Achkar, J.-P., & Gannon, J. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005535432163 · Cited by 35 · see citing works

Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment

Zhang, R., Zou, N., Li, J., Lv, H., Wei, J., Fang, X., & Qian, J. (2011) · International Journal of Colorectal Disease · doi:10.1007/s00384-011-1153-4 · Cited by 32 · see citing works

The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues

Ren, W., Hua, M.-L., Cao, F., & Zeng, W.-W. (2023) · Advancement of science · doi:10.1002/advs.202306128 · Cited by 31 · see citing works

Short-Term Effects of Relamorelin on Descending Colon Motility in Chronic Constipation: A Randomized, Controlled Trial

Acosta, A. J., Camilleri, M., Busciglio, I. A., Boldingh, A., Nelson, A. D., & Burton, D. D. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3876-5 · Cited by 30 · see citing works

The effects of clonidine on symptoms and anorectal sensorimotor function in women with faecal incontinence

Bharucha, A. E., Seide, B. M., & Zinsmeister, A. R. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04391.x · Cited by 30 · see citing works

Role of 5-HT1B/Dreceptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/Dreceptor antagonists

Ponti, F. D., Crema, F., Moro, E., Nardelli, G., Frigo, G., & Crema, A. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00280.2002 · Cited by 30 · see citing works

Pharmacogenetics of Low Dose Clonidine in Irritable Bowel Syndrome

Camilleri, M., Busciglio, I., Carlson, P., Mckinzie, S., Burton, D., Baxter, K., Ryks, M., & Zinsmeister, A. (2009) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2009.01263.x · Cited by 29 · see citing works

Pain Modulation and Autonomic Function: The Effect of Clonidine

Nahman‐Averbuch, H., Dayan, L., Sprecher, E., Hochberg, U., Brill, S., Yarnitsky, D., & Jacob, G. (2016) · Pain Medicine · doi:10.1093/pm/pnv102 · Cited by 28 · see citing works

Lower gastrointestinal functions

Bharucha, A. E. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01111.x · Cited by 28 · see citing works

Effects of glucagon‐like peptide‐1 and sympathetic stimulation on gastric accommodation in humans¹

Andrews, C. N., Bharucha, A. E., Camilleri, M., Low, P. A., Seide, B. M., Burton, D. D., Nickander, K. K., Baxter, K. L., & Zinsmeister, A. R. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00923.x · Cited by 26 · see citing works

The serotonin reuptake inhibitor citalopram does not affect colonic sensitivity or compliance in rats

Käll, E., Lindström, E., & Martı́nez, V. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.032 · Cited by 26 · see citing works

Altered Colorectal Compliance and Anorectal Physiology in Upper and Lower Motor Neurone Spinal Injury May Explain Bowel Symptom Pattern

Trivedi, P. M., Kumar, L., & Emmanuel, A. V. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.19 · Cited by 25 · see citing works

Potential Biomarkers

Spiller, R. E. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2011.01.001 · Cited by 25 · see citing works

Characterisation of colonic accommodation in Wistar Kyoto rats with impaired gastric accommodation

Martı́nez, V., Ryttinger, M., Kjerling, M., & Nielsen, M. A. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0195-1 · Cited by 25 · see citing works

What about clonidine for diarrhoea? A systematic review and meta-analysis of its effect in humans

Fragkos, K. C., Zárate-López, N., & Frangos, C. C. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x15625586 · Cited by 24 · see citing works

Association of alpha 2A adrenergic receptor gene (ADRΑ2A) polymorphism with irritable bowel syndrome, microscopic and ulcerative colitis

Sikander, A., Rana, S. V., Sharma, S. K., Sinha, S. K., Arora, S. K., Prasad, K. K., & Singh, K. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.10.003 · Cited by 23 · see citing works

Synchronized gastric electrical stimulation improves vagotomy-induced impairment in gastric accommodation via the nitrergic pathway in dogs

Chen, J., Koothan, T., & Chen, J. D. Z. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90525.2008 · Cited by 23 · see citing works

Towards identifying optimal doses for alpha‐2 adrenergic modulation of colonic and rectal motor and sensory function

Malcolm, A., Camilleri, Kost, Burton, Fett, & Zinsmeister, A. R. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00757.x · Cited by 71 · see citing works

Effects of an α2-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans

Viramontes, B. E., Malcolm, A., Camilleri, M., Szarka, L. A., McKinzie, S., Burton, D. D., & Zinsmeister, A. R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.6.g1468 · Cited by 93 · see citing works

Effect of clonidine on colonic motility in rats

Umezawa, T., Guo, S., Jiao, Y., & Hisamitsu, T. (2003) · Autonomic Neuroscience · doi:10.1016/s1566-0702(03)00105-x · Cited by 20 · see citing works

Adrenoceptors and regulation of intestinal tone in the isolated colon of the mouse

Fontaine, J., Grivegnee, A., & Reuse, J. (1984) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1984.tb10070.x · Cited by 56 · see citing works

Oral clonidine inhibits visceral pain-related viscerosomatic and cardiovascular responses to colorectal distension in rats

Brusberg, M., Ravnefjord, A., Lindgreen, M., Larsson, H., Lindström, E., & Martı́nez, V. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.056 · Cited by 10 · see citing works