The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
High Risk of Malignant Melanoma in Melanoma-Prone Families with Dysplastic Nevi
Abstract
The risk of hereditary cutaneous malignant melanoma was evaluated in 401 members of 14 families with an autosomal dominant form of melanoma. We documented 127 primary melanomas in 69 family members, including 39 new melanomas diagnosed in 22 study participants from the time of first examination through a maximum of 8 years of follow-up. The 39 newly diagnosed melanomas occurred only in family members with dysplastic nevi, a known precursor of familial melanoma. Of 77 patients with dysplastic nevus syndrome without prior melanomas, 4 developed their first melanoma during prospective follow-up, as compared with 0.03 cases expected. The prospective age-adjusted incidence for melanoma was 14.3/1000 patients with dysplastic nevus per year, with a cumulative melanoma risk (+/- SE) of 7.2% (+/- 3.6) at 8 years. The actuarial probability of melanoma developing in family members with dysplastic nevi was 56.0% (+/- 10.1) from age 20 to age 59. This study confirms that dysplastic nevi are clinical markers of high risk for, and precursors of, hereditary melanoma.
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Cites
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Breslow, A. (1970) · Annals of Surgery · doi:10.1097/00000658-197011000-00017 · Cited by 2,426
A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma
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Self-citationOrigin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'
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Self-citationStatistics with applications to the biological and health sciences
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Analysis of relative survival and proportional mortality
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Dysplastic nevus syndrome: A phenotypic association of sporadic cutaneous melanoma
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Self-citationThe prognostic significance of ulceration of cutaneous melanoma
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Acquired Precursors of Cutaneous Malignant Melanoma: The Familial Dysplastic Nevus Syndrome
Greene, M. H., Clark, W. H., Tucker, M. A., Elder, D. E., Kraemer, K. H., Guerry, D., Witmer, W. K., Thompson, J., Matozzo, I., & Fraser, M. C. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501103120205 · Cited by 336
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Cited by
Number of melanocytic nevi as a major risk factor for malignant melanoma
Holly, E. A., Kelly, J. W., Shpall, S. N., & Chiu, S.-H. (1987) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(87)70230-8 · Cited by 503
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Self-citationRhodes, A. R., Seki, Y., Fitzpatrick, T. B., & Stern, R. S. (1988) · Cancer · doi:10.1002/1097-0142(19880115)61:2<358::aid-cncr2820610227>3.0.co;2-# · Cited by 50
IL-23 Inhibits Melanoma Development by Augmenting DNA Repair and Modulating T Cell Subpopulations
Nasti, T. H., Cochran, J. B., Vachhani, R. V., McKay, K., Tsuruta, Y., Athar, M., Timares, L., & Elmets, C. A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601455 · Cited by 19
Metadata
- Authors
- GREENE, M. H., CLARK, W. H., TUCKER, M. A., KRAEMER, K. H., ELDER, D. E., & FRASER, M. C.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1985-04-01
- Volume
- 102
- Issue
- 4
- Pages
- 458-465
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2058134455
- Cited by
- 455
- References
- 21
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- GREENE, M. H., CLARK, W. H., TUCKER, M. A., KRAEMER, K. H., ELDER, D. E., & FRASER, M. C. (1985). High Risk of Malignant Melanoma in Melanoma-Prone Families with Dysplastic Nevi. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-102-4-458
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
