The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antibody to Hepatitis B Core Antigen as a Paradoxical Marker for Non-A, Non-B Hepatitis Agents in Donated Blood
Abstract
The relationship between the presence of antibody to hepatitis B core antigen (anti-HBc) in donor blood and the development of hepatitis in recipients of that blood was studied in 6293 blood donors and 481 recipients who were followed for 6 to 9 months after transfusion. Of 193 recipients of at least 1 unit of blood positive for anti-HBc, 23 (11.9%) developed non-A, non-B hepatitis compared with 12 (4.2%) of 288 recipients of only anti-HBc-negative blood (p less than 0.001). Donor anti-HBc status was not significantly associated with the development of hepatitis B in the recipient and was negatively associated with the development of cytomegalovirus hepatitis. The relationship of donor anti-HBc status and the development of non-A, non-B hepatitis in the recipient was independent of transfusion volume and elevated donor transaminase level. Although 88% of anti-HBc-positive blood units were not associated with recipient non-A, non-B hepatitis, calculation of maximal corrected efficacy predicted that exclusion of anti-HBc-positive donors might have prevented 43% of the cases of non-A, non-B hepatitis with a donor loss of 4%. Because of the serious chronic consequences of non-A, non-B hepatitis, surrogate tests for non-A, non-B virus carriers must be seriously considered.
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Citations
Cites
Some Methods for Strengthening the Common χ 2 Tests
Cochran, W. G. (1954) · Biometrics · doi:10.2307/3001616 · Cited by 3,718
Cited by
An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis
Kuo, G., Choo, Q.-L., Alter, H. J., Gitnick, G. L., Redeker, A. G., Purcell, R. H., Miyamura, T., Dienstag, J. L., Alter, M. J., Stevens, C. E., et al. (1989) · Science · doi:10.1126/science.2496467 · Cited by 3,346
Self-citationAlter, H. J., Nakatsuji, Y., Melpolder, J., Wages, J., Wesley, R., Shih, J. W.-K., & Kim, J. P. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703133361102 · Cited by 579
Self-citationA long-term study of hepatitis C virus replication in non-A, non-B hepatitis.
Farci, P., Alter, H. J., Wong, D., Miller, R. H., Shih, J. W., Jett, B., & Purcell, R. H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199107113250205 · Cited by 571
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Metadata
- Authors
- KOZIOL, D. E., HOLLAND, P. V., ALLING, D. W., MELPOLDER, J. C., SOLOMON, R. E., PURCELL, R. H., HUDSON, L. M., SHOUP, F. J., KRAKAUER, H., & ALTER, H. J.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1986-04-01
- Volume
- 104
- Issue
- 4
- Pages
- 488-495
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2019308386
- Cited by
- 328
- References
- 1
- FWCI
- 85.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antibody to Hepatitis B Core Antigen as a Paradoxical Marker for Non-A, Non-B Hepatitis Agents in Donated Blood. https://app.cochat.ai/papers/10.7326/0003-4819-104-4-488
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- KOZIOL, D. E., HOLLAND, P. V., ALLING, D. W., MELPOLDER, J. C., SOLOMON, R. E., PURCELL, R. H., HUDSON, L. M., SHOUP, F. J., KRAKAUER, H., & ALTER, H. J. (1986). Antibody to Hepatitis B Core Antigen as a Paradoxical Marker for Non-A, Non-B Hepatitis Agents in Donated Blood. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-104-4-488
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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