The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Confidence Intervals for Reporting Results of Clinical Trials
Abstract
Tests of statistical significance are often used by investigators in reporting the results of clinical research. Although such tests are useful tools, the significance levels are not appropriate indices of the size or importance of differences in outcome between treatments. Lack of "statistical significance" can be misinterpreted in small studies as evidence that no important difference exists. Confidence intervals are important but underused supplements to tests of significance for reporting the results of clinical investigations. Their usefulness is discussed here, and formulas are presented for calculating confidence intervals with types of data commonly found in clinical trials.
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Citations
Cites
Beta blockade during and after myocardial infarction: An overview of the randomized trials
Yusuf, S., Peto, R., Lewis, J., Collins, R., & Sleight, P. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(85)80003-7 · Cited by 3,205
Freiman, J. A., Chalmers, T. C., Smith, H., & Kuebler, R. R. (1978) · New England Journal of Medicine · doi:10.1056/nejm197809282991304 · Cited by 1,628
A Confidence Interval for the Median Survival Time
Brookmeyer, R., & Crowley, J. (1982) · Biometrics · doi:10.2307/2530286 · Cited by 914
Cited by
Rutgeerts, P., Hiele, M., Geboes, K., Peeters, M., Penninckx, F., Aerts, R., & Kerremans, R. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90121-3 · Cited by 743
Design of Treatment Trials for Functional Gastrointestinal Disorders
Irvine, E. J., Tack, J., Crowell, M. D., Gwee, K. A., Ke, M., Schmulson, M. J., Whitehead, W. E., & Spiegel, B. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.010 · Cited by 550
Review of survival analyses published in cancer journals
Altman, D., De Stavola, B., Love, S., & Stepniewska, K. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.364 · Cited by 438
Methodological challenges in the evaluation of prognostic factors in breast cancer.
Altman, D. G., & Lyman, G. H. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1006193704132 · Cited by 271
Michiels, S., Piedbois, P., Burdett, S., Syz, N., Stewart, L., & Pignon, J.-P. (2005) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462305050154 · Cited by 154
Metadata
- Authors
- SIMON, R.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1986-09-01
- Volume
- 105
- Issue
- 3
- Pages
- 429-435
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1965352960
- Cited by
- 416
- References
- 3
- FWCI
- 24.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- SIMON, R. (1986). Confidence Intervals for Reporting Results of Clinical Trials. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-105-3-429
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
