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Infection Prophylaxis in Acute Leukemia: A Comparison of Ciprofloxacin with Trimethoprim-Sulfamethoxazole and Colistin
Abstract
Fifty-six patients receiving remission induction treatment for acute leukemia were studied in a randomized trial comparing ciprofloxacin with trimethoprim-sulfamethoxazole plus colistin for prevention of infections. Both groups received amphotericin B for antifungal prophylaxis. Six major infections occurred in 28 patients receiving ciprofloxacin, and 11 major infections occurred in 28 patients receiving trimethoprim-sulfamethoxazole plus colistin. No infections caused by gram-negative bacilli were seen in the ciprofloxacin group (p less than 0.02). Ciprofloxacin prevented colonization with resistant gram-negative bacilli, but 12 resistant colonizing strains were isolated from 10 patients receiving trimethoprim-sulfamethoxazole plus colistin (p less than 0.01). Ciprofloxacin was better tolerated: 23 of 28 patients were highly compliant to the drug, compared with 15 of 28 patients in the trimethoprim-sulfamethoxazole group (p less than 0.05). These results suggest that ciprofloxacin is a promising drug for the prevention of infection in patients with granulocytopenia.
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Cited by
Patient Adherence and Medical Treatment Outcomes: A Meta-Analysis
Robin DiMatteo, M., Giordani, P. J., Lepper, H. S., & Croghan, T. W. (2002) · Medical Care · doi:10.1097/00005650-200209000-00009 · Cited by 1,490
Hughes, W. T., Armstrong, D., Bodey, G. R., Feld, R., Mandell, G. L., Meyers, J. D., Pizzo, P. A., Schimpff, S. C., Shenep, J. L., Wade, J. C., et al. (1990) · Journal of Infectious Diseases · doi:10.1093/infdis/161.3.381 · Cited by 403
Gafter-Gvili, A., Fraser, A., Paul, M., Vidal, L., Lawrie, T. A., van de Wetering, M. D., Kremer, L. C., & Leibovici, L. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004386.pub3 · Cited by 383
Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects
Sharma, P. C., Jain, A., Jain, S., Pahwa, R., & Yar, M. S. (2010) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756360903373350 · Cited by 353
Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS era.
Martin, J. N., Rose, D. A., Hadley, W. K., Perdreau‐Remington, F., Lam, P. K., & Gerberding, J. L. (1999) · The Journal of Infectious Diseases · doi:10.1086/315132 · Cited by 126
Metadata
- Authors
- DEKKER, A. W., ROZENBERG-ARSKA, M., & VERHOEF, J.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1987-01-01
- Volume
- 106
- Issue
- 1
- Pages
- 7-12
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2072977890
- Cited by
- 230
- References
- 0
- FWCI
- 14.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Infection Prophylaxis in Acute Leukemia: A Comparison of Ciprofloxacin with Trimethoprim-Sulfamethoxazole and Colistin. https://app.cochat.ai/papers/10.7326/0003-4819-106-1-7
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- DEKKER, A. W., ROZENBERG-ARSKA, M., & VERHOEF, J. (1987). Infection Prophylaxis in Acute Leukemia: A Comparison of Ciprofloxacin with Trimethoprim-Sulfamethoxazole and Colistin. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-106-1-7
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