Cited by 152Inflammatory Bowel DiseaseTryptophan and brain disordersOcular Diseases and Behçet’s Syndrome

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Do Life Events or Depression Exacerbate Inflammatory Bowel Disease?: A Prospective Study

North, Carol S., Alpers, David H., Helzer, John E., Spitznagel, Edward L., Clouse, Ray E.·1991·Annals of Internal Medicine

DOI 10.7326/0003-4819-114-5-381

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Abstract

OBJECTIVE: To determine whether depressed mood or life events are associated with an exacerbation of inflammatory bowel disease. DESIGN: A prospective study of a consecutive sample of patients with relapsing inflammatory bowel disease, followed by monthly questionnaires and periodic office visits. SETTING: A referral-based gastroenterology clinic at a medical school. PATIENTS: A consecutive sample of 32 patients with inflammatory bowel disease who had had at least one relapse in a 2-year period after entry into the study. MEASUREMENTS AND MAIN RESULTS: The Social Readjustment Rating Scale (measuring life events), the Beck Depression Inventory (a visual analog scale for depressed mood) and an inventory of intestinal symptoms were completed monthly by each subject with a 78% rate of compliance. A mean of 2.2 exacerbations was seen per subject during the study period. Life events were not temporally associated with changes in intestinal symptoms. Significant associations were found between intestinal symptoms and the two mood scales (P less than 0.05 for each), but no directionality in symptom occurrence could be detected in a time-lagged analysis. The results were similar when the months preceding exacerbations of inflammatory bowel disease were analyzed separately. CONCLUSIONS: Although these findings suggest that mood changed concurrently with exacerbation of inflammatory bowel disease, no evidence indicated that stressful life events or depressed mood precipitated exacerbations in this study group.

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Authors: North, C. S., Alpers, D. H., Helzer, J. E., Spitznagel, E. L., & Clouse, R. E.
Affiliations: Washington University in St. Louis (US)
ORCID: North, Carol S.
Alpers, David H.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 1991-03-01
Volume: 114
Issue: 5
Pages: 381-386
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-114-5-381
OpenAlex: W1979768971
Cited by: 152
References: 35
Citations by year: 2025: 2 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 5
FWCI: 2.35
Type: journal article
Language: en
Open access: closed
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: inflammatory bowel disease, depression, life events, disease exacerbation, intestinal symptoms, psychosocial factors, Social Readjustment Rating Scale, Beck Depression Inventory
MeSH terms: Colitis, Ulcerative, Crohn Disease, Depression, Humans, Life Change Events, Prospective Studies, Psychiatric Status Rating Scales, Surveys and Questionnaires, Recurrence, Regression Analysis

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Do Life Events or Depression Exacerbate Inflammatory Bowel Disease?: A Prospective Study

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