Cited by 152Inflammatory Bowel DiseaseTryptophan and brain disordersOcular Diseases and Behçet’s Syndrome

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Do Life Events or Depression Exacerbate Inflammatory Bowel Disease?: A Prospective Study

North, Carol S., Alpers, David H., Helzer, John E., Spitznagel, Edward L., Clouse, Ray E.·1991·Annals of Internal Medicine

DOI 10.7326/0003-4819-114-5-381

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Abstract

OBJECTIVE: To determine whether depressed mood or life events are associated with an exacerbation of inflammatory bowel disease. DESIGN: A prospective study of a consecutive sample of patients with relapsing inflammatory bowel disease, followed by monthly questionnaires and periodic office visits. SETTING: A referral-based gastroenterology clinic at a medical school. PATIENTS: A consecutive sample of 32 patients with inflammatory bowel disease who had had at least one relapse in a 2-year period after entry into the study. MEASUREMENTS AND MAIN RESULTS: The Social Readjustment Rating Scale (measuring life events), the Beck Depression Inventory (a visual analog scale for depressed mood) and an inventory of intestinal symptoms were completed monthly by each subject with a 78% rate of compliance. A mean of 2.2 exacerbations was seen per subject during the study period. Life events were not temporally associated with changes in intestinal symptoms. Significant associations were found between intestinal symptoms and the two mood scales (P less than 0.05 for each), but no directionality in symptom occurrence could be detected in a time-lagged analysis. The results were similar when the months preceding exacerbations of inflammatory bowel disease were analyzed separately. CONCLUSIONS: Although these findings suggest that mood changed concurrently with exacerbation of inflammatory bowel disease, no evidence indicated that stressful life events or depressed mood precipitated exacerbations in this study group.

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An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
The social readjustment rating scale
Holmes, T. H., & Rahe, R. H. (1967) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(67)90010-4 · Cited by 11,560
Psychiatric disorder in a sample of the general population with and without chronic medical conditions
(1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.8.976 · Cited by 641
Response Effects in Surveys
Hippler, H., & Schwarz, N. (1987) · Recent research in psychology · doi:10.1007/978-1-4612-4798-2_6 · Cited by 520
Yea-Saying, Nay-Saying, and Going to Extremes: Black-White Differences in Response Styles
Bachman, J. G., & O’Malley, P. M. (1984) · Public Opinion Quarterly · doi:10.1086/268845 · Cited by 371
Childhood Factors in Ulcerative Colitis and Crohn's Disease: An International Cooperative Study
Gilat, T., Hacohen, D., Lilos, P., & Langman, M. J. S. (1987) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528708991950 · Cited by 369
Psychiatric Illness and The Irritable Bowel Syndrome
Young, S. J., Alpers, D., Norland, C. C., & Woodruff, R. A. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80002-9 · Cited by 275
Self-citation
Psychiatric illness in patients with inflammatory bowel disease.
Andrews, H., Barczak, P., & Allan, R. N. (1987) · Gut · doi:10.1136/gut.28.12.1600 · Cited by 180
A study of the association between Crohn's disease and psychiatric illness
Helzer, J. E., Chammas, S., Norland, C. C., Stillings, W. A., & Alpers, D. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90418-9 · Cited by 168
Self-citation
Functional abdominal pain, psychiatric illness, and life events.
Creed, F. H., Craig, T., & Farmer, R. (1988) · Gut · doi:10.1136/gut.29.2.235 · Cited by 152

Show all 35 references

Research works printed but not linked: 2

Campbell D, 1986, Gastroenterology., 90, A1364
Lourens P, 1973, Ala J Med Sci., 10, 285

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THE RELATIONSHIP OF PSYCHIATRIC ILLNESS WITH GASTROINTESTINAL DISEASE
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Authors: North, C. S., Alpers, D. H., Helzer, J. E., Spitznagel, E. L., & Clouse, R. E.
Affiliations: Washington University in St. Louis (US)
ORCID: North, Carol S.
Alpers, David H.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 1991-03-01
Volume: 114
Issue: 5
Pages: 381-386
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-114-5-381
OpenAlex: W1979768971
Cited by: 152
References: 35
Citations by year: 2025: 2 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 5
FWCI: 2.35
Type: journal article
Language: en
Open access: closed
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: inflammatory bowel disease, depression, life events, disease exacerbation, intestinal symptoms, psychosocial factors, Social Readjustment Rating Scale, Beck Depression Inventory
MeSH terms: Colitis, Ulcerative, Crohn Disease, Depression, Humans, Life Change Events, Prospective Studies, Psychiatric Status Rating Scales, Surveys and Questionnaires, Recurrence, Regression Analysis

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Do Life Events or Depression Exacerbate Inflammatory Bowel Disease?: A Prospective Study

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