The DOI matches its Crossref record.
Contributions of Obesity and Weight Loss to Gallstone Disease
Abstract
Objective To examine the relation of obesity and weight loss to the formation of gallstones according to pertinent clinical and research issues. Data sources and extraction Original reports obtained through a MEDLINE search from 1966 to 1992 on gallstones plus obesity or reducing diets, supplemented by a manual search of bibliographies, a Current Contents title search from 1991 to 1992 on gallstones and gallbladder, and expert opinion. Only studies of humans were cited. Data synthesis For women, but less so for men, obesity is a strong risk factor for gallstones, and this risk is increased during weight loss. Between 10% and 25% of obese men and women may develop gallstones within a few months of beginning a very low calorie diet, and perhaps one third of these will develop symptoms of gallstones. Persons with the highest body mass index before weight loss and those who lose weight most rapidly appear to be at the greatest risk for gallstones. Treatment with ursodeoxycholic acid (ursodiol) during weight loss dieting is the only proven prevention for the formation of gallstones. Issues to be resolved include how different diets affect the risk for developing gallstones, the identification of other risk factors for gallstone formation during weight loss, the effect of weight loss among people with preexisting gallstones, and the optimum means of preventing gallstones during weight loss. Conclusions During weight loss, particularly among the obese, an increased risk exists for s…
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“Rapid weight loss, either by VLCD or bariatric surgery, is a known risk factor for gallstone formation.20”
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“Increased risk of gallstone formation during and after VLCD-induced rapid weight loss is incorporated in clinical recommendations as an adverse event, advising physicians to inform patients about this risk, but the risk magnitude has been unclear.7, 16, 20”
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Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914
Muscogiuri, G., El Ghoch, M., Colao, A., Hassapidou, M., Yumuk, V., Busetto, L., & Obesity Management Task Force (OMTF) of the European Association for the Study of Obesity (EASO) (2021) · Obesity Facts · doi:10.1159/000515381 · Cited by 289
Gastrointestinal Complications of Obesity
Camilleri, M., Malhi, H., & Acosta, A. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.052 · Cited by 269
Moreno, B., Bellido, D., Sajoux, I., Goday, A., Saavedra, D., Crujeiras, A. B., & Casanueva, F. F. (2014) · Endocrine · doi:10.1007/s12020-014-0192-3 · Cited by 222
Miller, K., Hell, E., Lang, B., & Lengauer, E. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000094305.77843.cf · Cited by 200
The Management of Very Low-Calorie Ketogenic Diet in Obesity Outpatient Clinic: A Practical Guide
Muscogiuri, G., Barrea, L., Laudisio, D., Pugliese, G., Salzano, C., Savastano, S., & Colao, A. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2104-z · Cited by 180
Faillie, J.-L., Yu, O. H., Yin, H., Hillaire-Buys, D., Barkun, A., & Azoulay, L. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.1531 · Cited by 134
Festi, D., Colecchia, A., Orsini, M., Sangermano, A., Sottili, S., Simoni, P., Mazzella, G., Villanova, N., Bazzoli, F., Lapenna, D., et al. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800634 · Cited by 90
Johansson, K., Sundström, J., Marcus, C., Hemmingsson, E., & Neovius, M. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.83 · Cited by 89
Effect of a dietary-induced weight loss on liver enzymes in obese subjects
Gasteyger, C., Larsen, T. M., Vercruysse, F., & Astrup, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1141 · Cited by 75
RISSANEN, A., & FOGELHOLM, M. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199911001-00024 · Cited by 49
Coleman, C. D., Kiel, J. R., Mitola, A. H., Langford, J. S., Davis, K. N., & Arterburn, L. M. (2015) · Nutrition Journal · doi:10.1186/s12937-015-0062-8 · Cited by 34
Metadata
- Authors
- Everhart, J. E.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1993-11-15
- Volume
- 119
- Issue
- 10
- Pages
- 1029-1035
- ISSN
- 0003-4819
- 1539-3704
- Cited by
- 189
- References
- 0
- Language
- en
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