Sucralfate and the Absorption of L-Thyroxine

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Letters15 July 1994Sucralfate and the Absorption of L-ThyroxineJohn A. Campbell, MD, Barbara A. Schmidt, MD, and John P. Bantle, MDJohn A. Campbell, MDSearch for more papers by this author, Barbara A. Schmidt, MDSearch for more papers by this author, and John P. Bantle, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-2-199407150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although an in vitro study showed binding of l-thyroxine by sucralfate [1], a later study showed that sucralfate did not interfere with in vivo absorption of replacement l-thyroxine in patients with hypothyroidism [2]. After encountering such a patient receiving replacement l-thyroxine who experienced a decrease in serum thyroxine (T4) index and a dramatic increase in serum thyrotropin after starting treatment with sucralfate, we studied the effect of sucralfate on l-thyroxine absorption.After obtaining informed consent and baseline tests, nine patients with primary hypothyroidism were randomly assigned to treatment with sucralfate, 1 g 4 times daily or placebo, ...References1. Havrankova J, Lahaie R. Levothyroxine binding by sucralfate. Ann Intern Med. 1992; 117:445-4. Google Scholar2. Khan F, Jeanniton E, Renedo M. Does sucralfate impede levothyroxine therapy? Ann Intern Med. 1993; 118:317. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGastrointestinal Malabsorption of ThyroxineConcurrent Milk Ingestion Decreases Absorption of LevothyroxineFactors Affecting Gastrointestinal Absorption of Levothyroxine: A ReviewGuidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone ReplacementInfluence of Drugs on Thyroid Function TestsDisorders of the Thyroid GlandConditions and drugs interfering with thyroxine absorptionInterference with the absorption of levothyroxineDrugs and Thyroid Function 15 July 1994Volume 121, Issue 2Page: 152KeywordsHypothyroidismPatientsThyroidThyroid-stimulating hormoneThyroxine ePublished: 15 August 2000 Issue Published: 15 July 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...