Cited by 475Hepatitis C virus researchHealth Promotion and Cardiovascular PreventionLiver Disease Diagnosis and Treatment

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Screening for hepatitis C virus infection in adults: U.S. Preventive Services Task Force recommendation statement.

Moyer, Virginia A.·2013·Annals of Internal Medicine

DOI 10.7326/0003-4819-159-5-201309030-00672

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Abstract

DESCRIPTION: Update of the 2004 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for and treatment of hepatitis C virus (HCV) infection in asymptomatic adults. METHODS: The Agency for Healthcare Research and Quality commissioned 2 systematic reviews on screening for and treatment of HCV infection in asymptomatic adults, focusing on evidence gaps identified in the previous USPSTF recommendation and new studies published since 2004. The evidence on screening for HCV in pregnant women was also considered. POPULATION: This recommendation applies to all asymptomatic adults without known liver disease or functional abnormalities. RECOMMENDATION: The USPSTF recommends screening for HCV infection in persons at high risk for infection. The USPSTF also recommends offering 1-time screening for HCV infection to adults born between 1945 and 1965. (B recommendation).

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Diagnosis, management, and treatment of hepatitis C: An update # † ‡
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Background
Medicaid expansion is associated with a higher likelihood of early diagnosis, resection, transplantation, and overall survival in patients with hepatocellular carcinoma
Elshami, M., Hoehn, R. S., Hue, J. J., Rothermel, L. D., Chavin, K. D., Ammori, J. B., Hardacre, J. M., Winter, J. M., & Ocuin, L. M. (2022) · HPB · doi:10.1016/j.hpb.2022.03.003 · Cited by 20
Hepatitis C: improving the quality of screening in a community hospital by implementing an electronic medical record intervention
Shahnazarian, V., Karu, E., & Mehta, P. H. (2015) · BMJ Quality Improvement Reports · doi:10.1136/bmjquality.u208549.w3409 · Cited by 20
“[2] Other risk factors include: incarceration, intranasal drug abuse, long-term hemodialysis, getting an unregulated tattoo, other percutaneous exposures, and being born to a mother that is infected with hepatitis C.[1] Also, it is important to note that while an HCV infection can be characterized from mild to severe,…”
BackgroundInfluential
The Effects of Alcohol on Other Chronic Liver Diseases
Hsu, C. C.-S., & Kowdley, K. V. (2016) · Clinics in Liver Disease · doi:10.1016/j.cld.2016.02.013 · Cited by 20
Use of direct-acting antiviral agents in hepatitis C virus-infected liver transplant candidates
Gadiparthi, C., Cholankeril, G. T., Perumpail, B. J., Yoo, E. R., Satapathy, S. K., Nair, S. P., & Ahmed, A. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i3.315 · Cited by 20
Five Questions Concerning Managing Hepatitis C in the Justice System
Spaulding, A. C., Adee, M. G., Lawrence, R., Chhatwal, J., & von Oehsen, W. H. (2018) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2018.02.014 · Cited by 20
Viral hepatitis, non-alcoholic fatty liver disease and alcohol as risk factors for hepatocellular carcinoma.
Gambarin‐Gelwan, M. (2013) · PubMed · doi:10.3978/j.issn.2304-3865.2013.09.02 · Cited by 20
Systematic review of the accuracy of antibody tests used to screen asymptomatic adults for hepatitis C infection
Cadieux, G., Campbell, J. R., & Dendukuri, N. (2016) · CMAJ Open · doi:10.9778/cmajo.20160084 · Cited by 20
Universal Screening for Hepatitis C Virus Infection
Graham, C. S., & Trooskin, S. B. (2020) · JAMA · doi:10.1001/jama.2019.22313 · Cited by 20
Implementation of baby boomer hepatitis C screening and linking to care in gastroenterology practices: a multi-center pilot study
Younossi, Z. M., LaLuna, L. L., Santoro, J. J., Mendes, F. D., Araya, V. R., Ravendhran, N., Pedicone, L. D., Lio, I., Nader, F., Hunt, S., et al. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0438-z · Cited by 19
Detecting Hepatitis B and C by Combined Public Health and Primary Care Birth Cohort Testing
Heil, J., Hoebe, C. J. P. A., Cals, J., ter Waarbeek, H. L. G., van Loo, I. H. M., & Dukers–Muijrers, N. H. T. M. (2018) · The Annals of Family Medicine · doi:10.1370/afm.2166 · Cited by 19
Disparities in Hepatocellular Carcinoma Incidence in California: An Update
Sangaramoorthy, M., Yang, J., DeRouen, M. C., Ho, C. K., Somsouk, M., Tana, M. M.-S., Thompson, C. A., Gibbons, J., Gomez, S. L., & Shariff‐Marco, S. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0560 · Cited by 19
Comparison of Hepatitis C Virus Testing Strategies
Smith, B. D., & Yartel, A. K. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.05.011 · Cited by 20
Occult Hepatitis C Virus Infection in Hemodialysis Patients; Single Center Study
El-Shishtawy, S., Sherif, N., Abdallh, E., Kamel, L. N., Abbas, M., Saleem, A. A. A., Abdalla, H., & Dine, H. G. E. (2015) · Electronic physician · doi:10.19082/1619 · Cited by 19
Sofosbuvir-Containing Regimens for Chronic Hepatitis C Are Successful in the Safety-Net Population: A Real-World Experience
Beck, K. R., Kim, N. J., & Khalili, M. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4340-x · Cited by 19
Limited Coverage of Hepatitis C Virus Testing in the United States, 2013–2017
Patel, E. U., Mehta, S. H., Boon, D., Quinn, T. C., Thomas, D. L., & Tobian, A. A. R. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy803 · Cited by 19
Management of Hepatitis C in 2019
Marks, K., & Naggie, S. (2019) · JAMA · doi:10.1001/jama.2019.5353 · Cited by 19
Undetectable Hepatitis C Viral Load Is Associated With Improved Outcomes Following Total Joint Arthroplasty
Novikov, D., Feng, J. E., Anoushiravani, A. A., Vigdorchik, J. M., Lajam, C. M., Seyler, T. M., & Schwarzkopf, R. M. (2019) · The Journal of Arthroplasty · doi:10.1016/j.arth.2019.06.058 · Cited by 19
Expanded Hepatitis C Virus Screening Recommendations Promote Opportunities for Care and Cure
Ngo‐Metzger, Q., Ward, J. W., & Valdiserri, R. O. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-5-201309030-00675 · Cited by 19
Universal Screening for Hepatitis C: An Important Step in Virus Elimination
Chhatwal, J., & Sussman, N. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.12.002 · Cited by 19
AGA Clinical Practice Update on Current Role of Blood Tests for Colorectal Cancer Screening: Commentary
Shaukat, A., Ladabaum, U., Kanth, P., & Lieberman, D. A. (2025) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2025.04.003 · Cited by 18
Enhancing the detection and management of acute hepatitis C virus infection
Martinello, M., & Matthews, G. V. (2015) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2015.07.003 · Cited by 18
Integrating Management of Hepatitis C Infection into Primary Care: the Key to Hepatitis C Elimination Efforts
Wang, A. E., Hsieh, E. P., Turner, B. J., & Terrault, N. A. (2022) · Journal of General Internal Medicine · doi:10.1007/s11606-022-07628-9 · Cited by 18
“In regard to health system–related barriers, the older USPSTF guidelines on HCV screening were risk-based or confined to a limited age group, which added an additional layer of complexity to screening efforts.(18) It is also important to note that HCV screening is not a quality of care metric, so it has lower priority…”
Relationship Between Hepatitis C Clinical Testing Site and Linkage to Care
Assoumou, S. A., Huang, W., Horsburgh, C. R., Drainoni, M., & Linas, B. P. (2014) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofu009 · Cited by 18
“In addition, the Centers for Disease Control and Prevention (CDC) and the United States Preventive Services Task Force (USPSTF) have been recommending one-time HCV testing for persons born between 1945 and 1965 [4, 5] since 2012 and 2013, respectively.”
Background
Chronic hepatitis B and C infection in the United States: a review of current guidelines, disease burden and cost effectiveness of screening
Sarpel, D., Baichoo, E., & Dieterich, D. T. (2016) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2016.1174066 · Cited by 18
Building a Hepatitis C Clinical Program: Strategies to Optimize Outcomes
Zuckerman, A. D., Carver, A. B., & Chastain, C. A. (2018) · Current treatment options in infectious diseases/Current treatment options in infectious disease · doi:10.1007/s40506-018-0177-5 · Cited by 18
Results of a Hepatitis C Virus Screening Program of the 1945–1965 Birth Cohort in a Large Emergency Department in New Jersey
Cornett, J. K., Bodiwala, V., Razuk, V., Shukla, D., & Narayanan, N. (2018) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy065 · Cited by 18
Hepatitis C virus: The 25-year journey from discovery to cure
Ward, J. W. (2014) · Hepatology · doi:10.1002/hep.27377 · Cited by 18
“recommendations for HCV testing (1-5); and most recently, by licensure of safe HCV therapeutics capable of curing almost all persons of their HCV infection(6).”
Background
Hepatitis C Virus Treatment: The Unyielding Chasm Between Efficacy and Effectiveness
Kanwal, F., & El‐Serag, H. B. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.02.031 · Cited by 17
Prevalence of Hepatitis C Virus Testing in Cohorts Born Between 1945 and 1965 in the U.S.
Jemal, A., & Fedewa, S. A. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.12.002 · Cited by 17
Brief Report
Haukoos, J. S., Hopkins, E., Bucossi, M. M., Lyons, M. S., Rothman, R. E., White, D. A. E., Al‐Tayyib, A., Bradley‐Springer, L. A., Campbell, J. D., Sabel, A. L., et al. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000518 · Cited by 17
Hepatitis C Virus
Kim, A. Y. (2016) · Annals of Internal Medicine · doi:10.7326/aitc201609060 · Cited by 17
Changing Landscape of Liver Cancer in California: A Glimpse Into the Future of Liver Cancer in the United States
Han, S. S., Kelly, S. P., Li, Y., Yang, B., Nguyen, M. H., So, S. K., Rosenberg, P. S., & Hsing, A. W. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy180 · Cited by 17
Hepatitis C in Black Individuals in the US
Falade-Nwulia, O. O., Kelly, S. M., Amanor-Boadu, S., Nnodum, B. N., Lim, J. K., & Sulkowski, M. (2023) · JAMA · doi:10.1001/jama.2023.21981 · Cited by 16

Authors: Moyer, V. A.
Affiliations: United States Preventive Services Task Force (US)
Corresponding author: Moyer, Virginia A.
ORCID: Moyer, Virginia A.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 2013-09
Volume: 159
Issue: 5
Pages: 349-357
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-159-5-201309030-00672
OpenAlex: W2148959572
Cited by: 475
References: 18
Citations by year: 2026: 2 · 2025: 11 · 2024: 5 · 2023: 8 · 2022: 21 · 2021: 23 · 2020: 40 · 2019: 50 · 2018: 59 · 2017: 57 · 2016: 68 · 2015: 59 · 2014: 52 · 2013: 19
FWCI: 41.16
Type: journal article
Language: en
Open access: closed
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: hepatitis C virus, HCV screening, asymptomatic adults, vulnerable populations, hepatitis C treatment, baby boomers, screening guidelines
MeSH terms: Adult, Age Factors, Antiviral Agents, Female, Humans, Mass Screening, Pregnancy, Pregnancy Complications, Infectious, Cost of Illness, Risk Assessment, Hepatitis C, Chronic, Early Diagnosis, Asymptomatic Diseases

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Screening for hepatitis C virus infection in adults: U.S. Preventive Services Task Force recommendation statement.

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