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Cited by 50Hormonal and reproductive studiesGrowth Hormone and Insulin-like Growth FactorsAdrenal Hormones and Disorders

THE ANABOLIC EFFECTS OF THE ANDROGENS AND SOMATIC GROWTH IN MAN

KENYON, ALLAN T., KNOWLTON, KATHRYN, SANDIFORD, IRENE·1944·Annals of Internal Medicine
DOI 10.7326/0003-4819-20-4-632
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Abstract

Article1 April 1944THE ANABOLIC EFFECTS OF THE ANDROGENS AND SOMATIC GROWTH IN MANALLAN T. KENYON, KATHRYN KNOWLTON, IRENE SANDIFORDALLAN T. KENYONSearch for more papers by this author, KATHRYN KNOWLTONSearch for more papers by this author, IRENE SANDIFORDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-4-632 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1889 Brown-Sequard,1then 72 years old, injected a testicular extract into himself and felt a return of his youthful sense of well-being. Little substance remains from this early experiment in human organotherapy although historians speak of an impetus given thereby to endocrine research. Such extracts of the testis are inactive in simple objective tests, and the subjective and probably imaginative character of Brown-Sequard's response never inspired much confidence in his interpretation of testicular function. Nevertheless the very prominence of this experiment in the history of endocrinology has served to keep alive Brown-Sequard's guiding thought that the testis might exert...Bibliography1. BROWN-SEQUARD CE: Expérience démontrant la puissance dynamogénique chez l'homme d'un liquide de testicules d'animaux, Arch. de physiol. norm. et path., 1889, xxi, 651, 740. Google Scholar2. SACCHI E: Di un caso di gigantismo infantile (pedomacrosomia) con tumore del testiculo, Riv. sper. di freniat., 1895, xxi, 149. Translation and illustrations given by Rowlands and Nicholson. Google Scholar3. ROWLANDSNICHOLSON RPGW: Growth of left testicle with precocious sexual and bodily development (macro-genitosomia), Guy's Hosp. Rep., 1929, lxxix, 401. Google Scholar4. SUTHERLAND DM: Macrogenitosomia, Brit. Jr. Surg., 1932, xx, 343. CrossrefGoogle Scholar5. STEWARTBELLROEHLKE CAETAB: Interstitial-cell tumor of testis with hypergenitalism in child of 5 years, Am. Jr. Cancer, 1936, xxvi, 144. CrossrefGoogle Scholar6. WERNERSPECTORVITTRossANDERSON AAHIAEWLWA: Pubertas precox in 6 year old boy produced by tumor of testis, probably of interstitial cell origin, Jr. Clin. Endocrinol., 1942, ii, 527. CrossrefGoogle Scholar7. WILKINSFLEISCHMANNHOWARD LWJE: Macrogenitosomia precox associated with hyperplasia of the androgenic tissue of the adrenal and death from cortico-adrenal insufficiency, Endocrinology, 1940, xxvi, 385. CrossrefGoogle Scholar8. GRAYAYRES HJG: Growth in private school children, 1931, University of Chicago Press, Chicago. Google Scholar9. RICHEY HG: The relation of accelerated, normal and retarded puberty to the height and weight of school children, Monographs of the Soc. for Res. in Child Dev., 1937, ii, no. 1. CrossrefGoogle Scholar10. SHUTTLEWORTH FR: The sexual maturation and the physical growth of girls, age six to nineteen, Monographs of the Soc. for Res. in Child Dev., National Research Council, Washington, 1937, ii, no. 5. Google Scholar11. BALDWIN BT, cited by SHUTTLEWORTH F. R.: The adolescent period, a graphic and pictorial atlas, Monographs of the Soc. for Res. in Child Dev., National Research Council, Washington, 1938, iii, no. 3, figure 19. Google Scholar12. KOCHAKIANMURLIN CDJR: The effect of male hormone on protein and energy metabolism of castrate dogs, Jr. Nutr., 1935, x, 437. CrossrefGoogle Scholar13. KOCHAKIANMURLIN CDJR: Relationship of synthetic male hormone, androstene dione to protein and energy metabolism of castrate dogs and protein metabolism of normal dog, Am. Jr. Physiol., 1936, cxvii, 642. CrossrefGoogle Scholar14. KOCHAKIAN CD: Testosterone and testosterone acetate and the protein and energy metabolism of castrate dogs, Endocrinology, 1937, xxi, 750. CrossrefGoogle Scholar15. KORENCHEVSKYDENNISONBROVSIN VMJ: Assay and effect of testosterone on rats compared with those of other sexual hormones, Biochem. Jr., 1936, xxx, 558. CrossrefGoogle Scholar16. THORNHARROP GWGA: The "sodium retaining effect" of sex hormones, Science, 1937, lxxxvi, 40. CrossrefGoogle Scholar17. KENYON AT: The effect of testosterone propionate on the genitalia, prostate, secondary sex characters and body weight in eunuchoidism, Endocrinology, 1938, xxiii, 121. CrossrefGoogle Scholar18. MCCULLAGHROSSMILLER EPHR: Methyl-testosterone. III. Effect upon body weight and growth, Jr. Clin. Endocrinol., 1941, i, 507. CrossrefGoogle Scholar19. KENYONSANDIFORDBRYANKNOWLTONKOCH ATIAHKFC: The effect of testosterone propionate on nitrogen, electrolyte, water and energy metabolism in eunuchoidism, Endocrinology, 1938, xxiii, 135. CrossrefGoogle Scholar20. KENYONKNOWLTONSANDIFORDKOCHLOTWIN ATKIFCG: A comparative study of the metabolic effects of testosterone propionate in normal men and women and in eunuchoidism, Endocrinology, 1940, xxvi, 26. CrossrefGoogle Scholar21. KNOWLTONKENYONSANDIFORDLOTWINFRICKER KATIGL: Comparative study of metabolic effects of estradiol benzoate and testosterone propionate in man, Jr. Clin. Endocrinol., 194

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Authors
KENYON, A. T., KNOWLTON, K., & SANDIFORD, I.
Affiliations
Chicago, Illinois
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1944-04-01
Volume
20
Issue
4
Pages
632-654
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-20-4-632
OpenAlex
W770900408
Cited by
50
References
51
Citations by year
2015: 1 · 2014: 1 · 2013: 2
FWCI
5.25
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
Annals of Internal Medicine (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
androgens, anabolic effects, physical growth, human growth, testicular extract, organotherapy, testicular tumors, precocious puberty, history of endocrinology, testicular function, growth hormone, insulin-like growth factor I, growth hormone binding protein

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