ASEPTIC MENINGITIS, A DISEASE OF DIVERSE ETIOLOGY: CLINICAL AND ETIOLOGIC STUDIES ON 854 CASES

Abstract

Article1 October 1953ASEPTIC MENINGITIS, A DISEASE OF DIVERSE ETIOLOGY: CLINICAL AND ETIOLOGIC STUDIES ON 854 CASESCHARLES V. ADAIR, ROSS L. GAULD, M.D., JOSEPH E. SMADEL, M.D.CHARLES V. ADAIR, ROSS L. GAULD, M.D., JOSEPH E. SMADEL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-4-675 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSporadic cases of infection of the central nervous system, presumably of viral origin, contribute much of the material received by a virus diagnostic laboratory. The present report is concerned with an analysis of material of this type submitted over a period of 11 years from military personnel, veterans and their dependents in the United States. Almost all of the 854 patients who provide the basis of this study presented clinical findings resembling the syndrome designated by Wallgren as acute aseptic meningitis.1In only a few of the patients was the clinical picture indicative of deep-seated neurologic involvement compatible with the...Bibliography1. Wallgren A: Une nouvelle maladie infectieuse due système nerveux central? Acta pædiat. 4: 158, 1925. CrossrefGoogle Scholar2. SmadelAdair JECV: Laboratory aspects of the differential diagnosis in acute poliomyelitis. Poliomyelitis: papers and discussions presented at the Second International Poliomyelitis Conference, 1952, J. B. Lippincott, Philadelphia, p. 164. Google Scholar3. SmadelBairdWall JERDMJ: A soluble antigen of lymphocytic choriomeningitis. I. Separation of soluble antigen from virus, J. Exper. Med. 70: 53, 1939. CrossrefMedlineGoogle Scholar4. Hammon WM: Encephalitis (arthropod-borne virus encephalitides and lymphocytic choriomeningitis): chapter in Diagnostic procedures for virus and rickettsial diseases, 1948, American Public Health Association, New York, p. 187. Google Scholar5. Rogers NG: The effect of Merthiolate on the infectivity of certain viruses, J. Lab. and Clin. Med. 38: 483, 1951. MedlineGoogle Scholar6. SmadelWall JEMJ: Identification of the virus of lymphocytic choriomeningitis, J. Bact. 41: 421, 1941. CrossrefMedlineGoogle Scholar7. EndersCohen JFS: Detection of antibody by complement-fixation in sera of man and monkey convalescent from mumps, Proc. Soc. Exper. Biol. and Med. 50: 180, 1942. CrossrefGoogle Scholar8. Habel K: Cultivation of mumps virus in the developing chick embryo and its application to studies of immunity to mumps in man, Pub. Health Rep. 60: 201, 1945. CrossrefMedlineGoogle Scholar9. LevensEnders JHJF: The hemoagglutinative properties of amniotic fluid from embryonated eggs infected with mumps virus, Science 102: 117, 1945. CrossrefMedlineGoogle Scholar10. BurnetLush FMD: The inactivation of herpes virus by immune sera: experiments using the chorio-allantoic membrane technique, J. Path. and Bact. 48: 275, 1939. CrossrefGoogle Scholar11. BurnetWilliams FMSW: Herpes simplex: a new point of view, M. J. Australia 1: 637, 1939. CrossrefGoogle Scholar12. SchüffnerMochtar WA: Versuche zur Aufteilung von Leptospirenstämmen, mit einleitenden Bemerkungen über den Verlauf von Agglutination und Lysis, Zentralbl. f. Bakt. 101: 405, 1927. Google Scholar13. GochenourYagerWetmoreHightower WSRHPWJA: Laboratory diagnosis of leptospirosis, Am. J. Pub. Health 43: 405-410, 1953. CrossrefGoogle Scholar14. Rasmussen AF: The laboratory diagnosis of lymphocytic choriomeningitis and mumps, Rocky Mountain Conference on Infantile Paralysis, 1946, University of Colorado School of Medicine and Hospitals, Denver, p. 45. Google Scholar15. Havens WP: Lymphocytic choriomeningitis—report of a case occurring in a granary harboring infected mice, J. A. M. A. 137: 857, 1948. CrossrefMedlineGoogle Scholar16. LépineMollaretKreis PPG: Réceptivité de l'homme au virus murin de la chorioméningite lymphocytaire. Reproduction expérimentale de la meningite lymphocytaire bénigne, Compt. rend. Acad. d. sc. 204: 1846, 1937. Google Scholar17. SmadelWall JEMJ: A soluble antigen of lymphocytic choriomeningitis. III. Independence of anti-soluble substance antibodies and neutralizing antibodies, and the rôle of soluble antigen and inactive virus in immunity to infection, J. Exper. Med. 72: 389, 1940. CrossrefMedlineGoogle Scholar18. BangBang HOJ: Involvement of central nervous system in mumps, Acta med. Scandinav. 113: 487, 1943. CrossrefGoogle Scholar19. Silver H: Meningitis in mumps, Acta med. Scandinav. 88: 355, 1936. Google Scholar20. LevisonThordarson HO: Mumps meningitis and meningo-encephalitis, Acta med. Scandinav. 112: 314, 1942. CrossrefGoogle Scholar21. Steinberg CL: Mumps meningo-encephalitis, U. S. Nav. M. Bull. 42: 567, 1944. Google Scholar22. FoxGrotts MJBF: Central nervous system involvement in parotitis, J. Pediat. 35: 561, 1949. CrossrefMedlineGoogle Scholar23. EndersCohenKane JFSLW: Immunity in mumps. II. The development of complement-fixing antibody and dermal hypersensitivity in human beings following