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The Hypereosinophilic Syndromes
Abstract
This report concerns three individuals with a similar illness characterized by the following: a striking leukocytosis due primarily to increased numbers of mature eosinophils; cardiac or pulmonary symptoms, or both; and hepatosplenomegaly. Two of the patients died; the third remains in clinical good health. Distinctive morphologic abnormalities were found in the heart, bone marrow, liver, and spleen. Similar cases have often been reported as examples of eosinophilic leukemia. However, review of the pertinent evidence is not thought to support this concept; rather, it suggests an association with Löffler's syndrome and Löffler's endocarditis parietalis fibroplastica. To emphasize that such patients are part of a continuum, we propose the term "hypereosinophilic syndromes" to encompass the entire group.
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Citations
Cited by
The idiopathic hypereosinophilic syndrome
Weller, P., & Bubley, G. (1994) · Blood · doi:10.1182/blood.v83.10.2759.2759 · Cited by 929
FAUCI, A. S., HARLEY, J. B., ROBERTS, W. C., FERRANS, V. J., GRALNICK, H. R., & BJORNSON, B. H. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-97-1-78 · Cited by 823
Episodic Angioedema Associated with Eosinophilia
Gleich, G. J., Schroeter, A. L., Marcoux, J. P., Sachs, M. I., O'Connell, E. J., & Kohler, P. F. (1984) · New England Journal of Medicine · doi:10.1056/nejm198406213102501 · Cited by 363
Approaches to the treatment of hypereosinophilic syndromes: A workshop summary report
Klion, A. D., Bochner, B. S., Gleich, G. J., Nutman, T. B., Rothenberg, M. E., Simon, H.-U., Wechsler, M. E., Weller, P. F., & the Hypereosinophilic Syndromes Working Group (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.02.042 · Cited by 342
The cardiovascular manifestations of the hypereosinophilic syndrome
Parrillo, J. E., Borer, J. S., Henry, W. L., Wolff, S. M., & Fauci, A. S. (1979) · The American Journal of Medicine · doi:10.1016/0002-9343(79)90227-4 · Cited by 314
Metadata
- Authors
- HARDY, W. R., & ANDERSON, R. E.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1968-06-01
- Volume
- 68
- Issue
- 6
- Pages
- 1220-1229
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1968147012
- Cited by
- 490
- References
- 0
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- HARDY, W. R., & ANDERSON, R. E. (1968). The Hypereosinophilic Syndromes. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-68-6-1220
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
