The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans
Abstract
The pharmacokinetics of intravenously administered lidocaine were studied in 10 normal subjects, 11 patients with heart failure, 8 patients with alcoholic liver disease, and 6 chronic renal dialysis patients. In heart failure subjects, both the measured volume of distribution and plasma clearance were significantly reduced. Liver disease subjects showed a reduced plasma clearance and prolongation of the "dominant phase" half-life. Neither volume of distribution nor clearance was abnormal in renal disease subjects. The alterations in volume of distribution and clearance are related to the activity of the circulation in drug disposition. The low clearance implies the need to decrease dosage regimens or alter infusion rates in patients with advanced heart failure or liver disease.
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Citations
Cites
Catheterization of the Heart in Man with Use of a Flow-Directed Balloon-Tipped Catheter
Swan, H. J. C., Ganz, W., Forrester, J., Marcus, H., Diamond, G., & Chonette, D. (1970) · New England Journal of Medicine · doi:10.1056/nejm197008272830902 · Cited by 2,137
Interrelationships of Hepatic Blood Flow, Cardiac Output, and Blood Levels of Lidocaine in Man
STENSON, R. E., CONSTANTINO, R. T., & HARRISON, D. C. (1971) · Circulation · doi:10.1161/01.cir.43.2.205 · Cited by 268
DISPOSITION KINETICS OF LIDOCAINE IN NORMAL SUBJECTS*
Rowland, M., Thomson, P. D., Guichard, A., & Melmon, K. L. (1971) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1971.tb46915.x · Cited by 191
Self-citationBIGGER, J. T., SCHMIDT, D. H., & KUTT, H. (1968) · Circulation · doi:10.1161/01.cir.38.2.363 · Cited by 166
The uptake of thiopental by body tissues and its relation to the duration of narcosis
Price, H. L., Kovnat, P. J., Safer, J. N., Conner, E. H., & Price, M. L. (1960) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt19601116 · Cited by 150
Cardiovascular effects of infusion of lidocaine on patients with heart disease
Grossman, J. I., Cooper, J. A., & Frieden, J. H. (1969) · The American Journal of Cardiology · doi:10.1016/0002-9149(69)90403-2 · Cited by 66
Cited by
The effects of age and liver disease on the disposition and elimination of diazepam in adult man.
Klotz, U., Avant, G. R., Hoyumpa, A., Schenker, S., & Wilkinson, G. R. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107938 · Cited by 696
Berg, M. D., Schexnayder, S. M., Chameides, L., Terry, M., Donoghue, A., Hickey, R. W., Berg, R. A., Sutton, R. M., & Hazinski, M. F. (2010) · Pediatrics · doi:10.1542/peds.2010-2972c · Cited by 398
Complications of fiberoptic bronchoscopy.
Credle, W. F., Smiddy, J. F., & Elliott, R. C. (1974) · PubMed · doi:10.1164/arrd.1974.109.1.67 · Cited by 301
Drug Use in the Elderly: A Review of Problems and Special Considerations
Vestal, R. E. (1978) · Drugs · doi:10.2165/00003495-197816040-00004 · Cited by 287
Foo, I., Macfarlane, A. J. R., Srivastava, D., Bhaskar, A., Barker, H., Knaggs, R., Eipe, N., & Smith, A. F. (2021) · Anaesthesia · doi:10.1111/anae.15270 · Cited by 284
Metadata
- Authors
- THOMSON, P. D., MELMON, K. L., RICHARDSON, J. A., COHN, K., STEINBRUNN, W., CUDIHEE, R., & ROWLAND, M.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1973-04-01
- Volume
- 78
- Issue
- 4
- Pages
- 499-508
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2010904013
- Cited by
- 512
- References
- 6
- FWCI
- 17.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans. https://app.cochat.ai/papers/10.7326/0003-4819-78-4-499
- The paper
- THOMSON, P. D., MELMON, K. L., RICHARDSON, J. A., COHN, K., STEINBRUNN, W., CUDIHEE, R., & ROWLAND, M. (1973). Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-78-4-499
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
