Moderate Ethanol Ingestion and Plasma Triglyceride Levels: A Study in Normal and Hypertriglyceridemic Persons
Abstract
Moderate amounts of ethanol were given three times daily for 7 days to nonalcoholic normal persons and hypertriglyceridemic persons, and plasma lipid, glucose, and insulin levels were measured. In the hypertriglyceridemic subjects, ethanol ingestion caused fasting plasma triglyceride levels to rise, from a control value of 338 ± 71 mg/100 ml to 498 ± 117 mg/100 ml (P < 0.05). There was no significant change in the fasting plasma triglyceride levels of the normal persons. The postprandial triglyceride response to ethanol rose 37% in the normal group and 44% in the hypertriglyceridemic group (P < 0.05 for both groups). There were no changes in the fasting or postprandial glucose and insulin levels during ethanol ingestion. The daily use of moderate amounts of alcohol seems to [1] significantly exacerbate preexisting hypertriglyceridemia, which should be considered when treating patients with this disorder, but [2] does not alter plasma glucose or insulin levels in the fasting or postprandial state.
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Simultaneous ingestion of alcohol impairs chylomicron hydrolysis.
“Simultaneous ingestion of alcohol impairs chylomicron hydrolysis and also increases triglyceride production and secretion of triglyceride-rich VLDL (97,98).”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [97]
Simultaneous ingestion of alcohol increases triglyceride production and secretion of triglyceride-rich VLDL.
“Simultaneous ingestion of alcohol impairs chylomicron hydrolysis and also increases triglyceride production and secretion of triglyceride-rich VLDL (97,98).”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [97]
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- Authors
- GINSBERG, H., OLEFSKY, J., FARQUHAR, J. W., & REAVEN, G. M.
- Affiliations
- Palo Alto, California
- Corresponding author
- GINSBERG, HENRY
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1974-02-01
- Volume
- 80
- Issue
- 2
- Pages
- 143-149
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2004741651
- Cited by
- 144
- References
- 1
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 2
- FWCI
- 13.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- ethanol consumption, plasma triglycerides, hypertriglyceridemia, postprandial triglyceride response, fasting plasma triglycerides, plasma glucose, insulin levels
- MeSH terms
- Adult, Ethanol, Blood Glucose, Cholesterol, Fasting, Fatty Acids, Nonesterified, Female, Humans, Hyperlipidemias, Insulin, Lipids, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Male, Middle Aged, Time Factors, Triglycerides
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