The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Lactate Homeostasis and Lactic Acidosis
Abstract
The roles of changes in cellular redox, interorgan lactate flux and balance, and quantitative aspects of lactate metabolism in the pathogenesis of lactic acidosis are discussed. Altered metabolism of pyruvate is central to the development of lactic acidosis and hyperlactatemia. Lactic acidosis occurs as a result of a relative or absolute imbalance in lactate production and utilization. Lactate utilization for oxidative purposes and for the resynthesis of glucose is essential for the maintenance of acid-base balance. Because of its role in lactate homeostasis the liver may play a central role in acid-base balance. Impairment of hepatic utilization of lactate may produce lactic acidosis.
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Citations
Cites
Substrate Turnover during Prolonged Exercise in Man
Ahlborg, G., Felig, P., Hagenfeldt, L., Hendler, R., & Wahren, J. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107645 · Cited by 786
Glucose metabolism during leg exercise in man
Wahren, J., Felig, P., Ahlborg, G., & Jorfeldt, L. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106772 · Cited by 598
Acid-base balance after maximal exercise of short duration
Osnes, J. B., & Hermansen, L. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.1.59 · Cited by 204
Diabetic ketoacidosis: new concepts and trends in pathogenesis and treatment
KREISBERG, R. A. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-88-5-681 · Cited by 179
Self-citationBalance and kinetics of anaerobic energy release during strenuous exercise in man
Margaria, R., Cerretelli, P., & Mangili, F. (1964) · Journal of Applied Physiology · doi:10.1152/jappl.1964.19.4.623 · Cited by 150 · cited 1×
“Plasma lactate concentrations may reach 20 to 30 mM after maximum work of short duration (29, 30) representing a lactate production rate of 10 to 20 mmol/ k g m i n for 30 s (31).”
Cited by
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
Salpeter, S. R., Greyber, E., Pasternak, G. A., & Salpeter (posthumous), E. E. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002967.pub4 · Cited by 893
Comprehensive review on lactate metabolism in human health
Adeva-Andany, M., López-Ojén, M., Funcasta-Calderón, R., Ameneiros-Rodríguez, E., Donapetry-García, C., Vila-Altesor, M., & Rodríguez-Seijas, J. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.05.007 · Cited by 615
The pharmacology of dichloroacetate
Stacpoole, P. W. (1989) · Metabolism · doi:10.1016/0026-0495(89)90051-6 · Cited by 484
An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81
Ahmed, K., Tunaru, S., Tang, C., Müller, M., Gille, A., Sassmann, A., Hanson, J., & Offermanns, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.012 · Cited by 440
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
Salpeter, S. R., Greyber, E., Pasternak, G. A., & Salpeter (posthumous), E. E. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002967.pub3 · Cited by 434
Metadata
- Authors
- KREISBERG, R. A.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1980-02-01
- Volume
- 92
- Issue
- 2_Part_1
- Pages
- 227-237
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2057105708
- Cited by
- 361
- References
- 5
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
