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Curability of Advanced Hodgkin's Disease with Chemotherapy: Long-Term Follow-up of MOPP-Treated Patients at the National Cancer Institute
Abstract
The results of treatment of 198 patients with Hodgkin's disease with MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) were analyzed. Eighty percent attained complete remission, and 68% of patients achieving a complete remission have remained disease free beyond 10 years from the end of treatment. Results of autopsy on patients who died of other causes while in clinical complete remission did not show evidence of residual tumors except in one patient. Asymptomatic patients and patients with mixed-cellularity or lymphocytic-depleted Hodgkin's disease do significantly better than symptomatic patients and those with nodular sclerosing histologic type. Advanced Hodgkin's disease appears to be curable by chemotherapy.
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Cites
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Self-citationCombination Chemotherapy in the Treatment of Advanced Hodgkin's Disease
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Self-citationIntensive Combination Chemotherapy and X-Irradiation in Hodgkin's Disease
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Vasan, N., Baselga, J., & Hyman, D. M. (2019) · Nature · doi:10.1038/s41586-019-1730-1 · Cited by 2,770
Breast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology
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Metadata
- Authors
- DEVITA, V. T., SIMON, R. M., HUBBARD, S. M., YOUNG, R. C., BERARD, C. W., MOXLEY, J. H., FREI, E., CARBONE, P. P., & CANELLOS, G. P.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1980-05-01
- Volume
- 92
- Issue
- 5
- Pages
- 587-595
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2041629407
- Cited by
- 468
- References
- 9
- FWCI
- 26.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Curability of Advanced Hodgkin's Disease with Chemotherapy: Long-Term Follow-up of MOPP-Treated Patients at the National Cancer Institute. https://app.cochat.ai/papers/10.7326/0003-4819-92-5-587
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- DEVITA, V. T., SIMON, R. M., HUBBARD, S. M., YOUNG, R. C., BERARD, C. W., MOXLEY, J. H., FREI, E., CARBONE, P. P., & CANELLOS, G. P. (1980). Curability of Advanced Hodgkin's Disease with Chemotherapy: Long-Term Follow-up of MOPP-Treated Patients at the National Cancer Institute. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-92-5-587
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.