The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Leukocyte Interferon-Induced Tumor Regression in Human Metastatic Breast Cancer, Multiple Myeloma, and Malignant Lymphoma
Abstract
Thirty-eight patients with advanced breast cancer, multiple myeloma, and malignant lymphoma were treated with partially purified (about 0.1%) leukocyte interferon. Patients were treated with a remission-induction schedule of 3 million to 9 million antiviral units daily intramuscularly for 4 to 26 weeks. Responding patients were maintained on a schedule of 3 million U three times weekly. Tumor regression was observed in seven of 17 patients with breast cancer. Six of 10 patients with multiple myeloma responded with a decrease of at least 50% in serum myeloma protein levels or Bence Jones protein excretion. Six of the 11 lymphoma patients achieved tumor regression. Complete remissions occurred in two patients. Of the 19 responding patients, five remain on study for 52 to 63 weeks. Toxicity included low-grade fever, fatigue, anorexia, and partial alopecia. Myelosuppression (lowest median leukocyte count, 2500/mm3; granulocytes, 1300/mm3) occurred in most patients. On the basis of this pilot study, we conclude that leukocyte interferon can induce tumor regression in patients with advanced cancer.
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Citations
Cites
Virus interference. I. the interferon
Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451
Cited by
Cytokines in the Treatment of Cancer
Conlon, K. C., Miljkovic, M. D., & Waldmann, T. A. (2019) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2018.0019 · Cited by 518
Cytokines in Cancer Immunotherapy
Waldmann, T. A. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028472 · Cited by 507
Clinical investigation of human alpha interferon in chronic myelogenous leukemia
Talpaz, M., Kantarjian, H., McCredie, K., Keating, M., Trujillo, J., & Gutterman, J. (1987) · Blood · doi:10.1182/blood.v69.5.1280.1280 · Cited by 328
Self-citationTreatment of hairy cell leukemia with recombinant alpha-interferon
Quesada, Jr., Hersh, E., Manning, J., Reuben, J., Keating, M., Schnipper, E., Itri, L., & Gutterman, J. (1986) · Blood · doi:10.1182/blood.v68.2.493.493 · Cited by 278
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Metadata
- Authors
- GUTTERMAN, J. U., BLUMENSCHEIN, G. R., ALEXANIAN, R., YAP, H.-Y., BUZDAR, A. U., CABANILLAS, F., HORTOBAGYI, G. N., HERSH, E. M., RASMUSSEN, S. L., HARMON, M., KRAMER, M., & PESTKA, S.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1980-09-01
- Volume
- 93
- Issue
- 3
- Pages
- 399-406
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2144360148
- Cited by
- 497
- References
- 1
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- GUTTERMAN, J. U., BLUMENSCHEIN, G. R., ALEXANIAN, R., YAP, H.-Y., BUZDAR, A. U., CABANILLAS, F., HORTOBAGYI, G. N., HERSH, E. M., RASMUSSEN, S. L., HARMON, M., KRAMER, M., & PESTKA, S. (1980). Leukocyte Interferon-Induced Tumor Regression in Human Metastatic Breast Cancer, Multiple Myeloma, and Malignant Lymphoma. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-93-3-399
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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