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Cited by 196Fungal Infections and StudiesAntifungal resistance and susceptibilityHistiocytic Disorders and Treatments

Risk Factors for Disseminated or Fatal Histoplasmosis: Analysis of a Large Urban Outbreak

WHEAT, LAWRENCE JOSEPH, SLAMA, THOMAS G., NORTON, JAMES A, KOHLER, RICHARD B., EITZEN, HAL E., FRENCH, MORRIS L. V., SATHAPATAYAVONGS, BOONMEE·1982·Annals of Internal Medicine
DOI 10.7326/0003-4819-96-2-159
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Abstract

An outbreak of histoplasmosis in Indianapolis involving 488 clinically recognized cases including 60 patients with disseminated or fatal infection permitted statistical analysis of risk factors. Being male, white, under 5 years of age, having chronic obstructive lung disease, and living near the presumed source of the outbreak were not risk factors for fatal or disseminated histoplasmosis. Age greater than 54 years and immunosuppression were the only risk factors for disseminated or fatal infection. Dissemination should be excluded in patients with histoplasmosis who are immunosuppressed or older than 54 years. Specific antifungal treatment is more likely to be required in those two groups rather than in patients without risk factors.

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Crossref · 10.7326/0003-4819-96-2-159

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  • Early in the HIV pandemic, reports demonstrated an increased risk of death associated with advanced AIDS, immunocompromised states, chronic renal disease, and prolonged use of corticosteroids or TNF antagonists.

    “Early in the HIV pandemic, reports of Histoplasma spp. outbreaks [164–166] demonstrated an increased risk of death associated with advanced AIDS (CD4 counts <75 mm3), immunocompromised states (such as solid organ transplantation), chronic renal disease, and prolonged use of corticosteroids or tumor necrosis factor (TNF) antagonists [164,166,167].”

    From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [167]

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Authors
WHEAT, L. J., SLAMA, T. G., NORTON, J. A., KOHLER, R. B., EITZEN, H. E., FRENCH, M. L. V., & SATHAPATAYAVONGS, B.
Affiliations
Indianapolis, Indiana
Corresponding author
WHEAT, LAWRENCE JOSEPH
ORCID
WHEAT, LAWRENCE JOSEPH
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1982-02-01
Volume
96
Issue
2
Pages
159-163
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-96-2-159
OpenAlex
W2089020785
Cited by
196
References
30
Citations by year
2026: 3 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 2
FWCI
4.90
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Physiology › Histiocytic Disorders and Treatments
Keywords
histoplasmosis, disseminated histoplasmosis, risk factors, immunosuppression, age, chronic obstructive pulmonary disease, outbreak, antifungal therapy
MeSH terms
Adolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Disease Outbreaks, Female, Histoplasmosis, Humans, Immunosuppression Therapy, Indiana, Infant, Male, Middle Aged, Poverty Areas, Risk, Racial Groups

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