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Colonie Polyps in Patients with Acromegaly
Abstract
Seventeen patients with acromegaly were prospectively studied with barium enemas and colonoscopy to investigate the possibility that acromegaly is associated with an increased frequency of colonic polyps and colon cancer. Polyps were identified in nine patients and were removed and examined in eight. In five patients the polyps were adenomatous, and in four of the five there were multiple polyps. The presence of polyps closely correlated with the presence of skin tags (p = 0.041) and also with the age of the patient (p less than 0.01). No new cases of colonic cancer were discovered; however, reviewing the records of 44 patients with acromegaly, four cases were previously diagnosed with colon carcinoma. This study identifies a unique group of patients that are at risk for the development of colonic polyps and perhaps colon cancer.
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Cited by
Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management
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Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence
Giovannucci, E. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.11.3109s · Cited by 959
Giovannucci, E. (1995) · Cancer Causes and Control · doi:10.1007/bf00052777 · Cited by 817
Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis
Grodstein, F., Newcomb, P. A., & Stampfer, M. J. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00063-7 · Cited by 584
Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis
Grimberg, A., & Cohen, P. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200004)183:1<1::aid-jcp1>3.0.co;2-j · Cited by 506
Metadata
- Authors
- KLEIN, I., GULNAR, P., GAVALER, J. S., & DAVID H., V.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1982-07-01
- Volume
- 97
- Issue
- 1
- Pages
- 27-30
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1976102374
- Cited by
- 165
- References
- 0
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Colonie Polyps in Patients with Acromegaly. https://app.cochat.ai/papers/10.7326/0003-4819-97-1-27
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- KLEIN, I., GULNAR, P., GAVALER, J. S., & DAVID H., V. (1982). Colonie Polyps in Patients with Acromegaly. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-97-1-27
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
