The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management
Open accessAbstract
This review focuses on the systemic complications of acromegaly. Mortality in this disease is increased mostly because of cardiovascular and respiratory diseases, although currently neoplastic complications have been questioned as a relevant cause of increased risk of death. Biventricular hypertrophy, occurring independently of hypertension and metabolic complications, is the most frequent cardiac complication. Diastolic and systolic dysfunction develops along with disease duration; and other cardiac disorders, such as arrhythmias, valve disease, hypertension, atherosclerosis, and endothelial dysfunction, are also common in acromegaly. Control of acromegaly by surgery or pharmacotherapy, especially somatostatin analogs, improves cardiovascular morbidity. Respiratory disorders, sleep apnea, and ventilatory dysfunction are also important contributors in increasing mortality and are beneficially advantaged by controlling GH and IGF-I hypersecretion. An increased risk of colonic polyps, which more frequently recur in patients not controlled after treatment, has been reported by several independent investigations, although malignancies in other organs have also been described, but less convincingly than at the gastrointestinal level. Finally, the most important cause of morbidity and functional disability of the disease is arthropathy, which can be reversed at an initial stage, but not if the disease is left untreated for several years.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699
Physiological aspects of primary hypertension.
Folkow, B. (1982) · Physiological Reviews · doi:10.1152/physrev.1982.62.2.347 · Cited by 1,768 · cited 1×
“Folkow’s hypothesis (173), the increased blood pressure in GH excess could directly originate from an increased thickness of wall resistance vessels.”
BackgroundRizza, R. A., Mandarino, L. J., & Gerich, J. E. (1982) · Diabetes · doi:10.2337/diab.31.8.663 · Cited by 440 · cited 1×
“Moreover, GH modulates tissue response to insulin; indeed GH excess may cause insulin resistance, whereas GH deficiency may increase the sensitivity to insulin (203).”
BackgroundROSENFELD, R. G., WILSON, D. M., DOLLAR, L. A., BENNETT, A., & HINTZ, R. L. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-5-1033 · Cited by 155
Diabetes-Haufigkeit bei Akromegalie und Cushing-Syndrom
Biering, H., Knappe, G., Gerl, H., & Lochs, H. (2000) · Acta Medica Austriaca · doi:10.1046/j.1563-2571.2000.00106.x · Cited by 113
Bone mineral density and parameters of bone metabolism in patients with acromegaly
Kotzmann, H., Bernecker, P., Hübsch, P., Pietschmann, P., Woloszczuk, W., Svoboda, T., Geyer, G., & Luger, A. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650080410 · Cited by 98
Cited by
Diagnosis and Treatment of Pituitary Adenomas: A Review
Molitch, M. E. (2017) · JAMA · doi:10.1001/jama.2016.19699 · Cited by 933
A Consensus Statement on acromegaly therapeutic outcomes
Melmed, S., Bronstein, M. D., Chanson, P., Klibanski, A., Casanueva, F. F., Wass, J. A. H., Strasburger, C. J., Luger, A., Clemmons, D. R., & Giustina, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0058-5 · Cited by 561
Mortality in Patients with Pituitary Disease
Sherlock, M., Ayuk, J., Tomlinson, J. W., Toogood, A. A., Aragon-Alonso, A., Sheppard, M. C., Bates, A. S., & Stewart, P. M. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0033 · Cited by 392
Günther, T., Tulipano, G., Dournaud, P., Bousquet, C., Csaba, Z., Kreienkamp, H.-J., Lupp, A., Korbonits, M., Castaño, J. P., Wester, H.-J., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015388 · Cited by 253
Sherlock, M., Reulen, R. C., Alonso, A. A., Ayuk, J., Clayton, R. N., Sheppard, M. C., Hawkins, M. M., Bates, A. S., & Stewart, P. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1097 · Cited by 185
Metadata
- Authors
- Colao, A., Ferone, D., Marzullo, P., & Lombardi, G.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2004-02-01
- Volume
- 25
- Issue
- 1
- Pages
- 102-152
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2118341413
- Cited by
- 1,309
- References
- 6
- FWCI
- 26.71
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management. https://app.cochat.ai/papers/10.1210/er.2002-0022
- The paper
- Colao, A., Ferone, D., Marzullo, P., & Lombardi, G. (2004). Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management. Endocrine Reviews. https://doi.org/10.1210/er.2002-0022
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
