The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Vancomycin Therapy for Methicillin-Resistant Staphylococcus aureus
Abstract
Ten patients with bacteremia due to methicillin-resistant Staphylococcus aureus were treated with vancomycin. These patients were compared with matched controls, nine bacteremic patients with methicillin-sensitive S. aureus, and one patient with penicillin-sensitive S. aureus. Controls were treated with a penicillin. There were no significant differences in time to defervescence, metastatic infections, relapse, mortality, need for surgical drainage, or duration of therapy. Fifteen of 19 episodes of serious methicillin-resistant S. aureus infection responded to vancomycin. Severe toxic effects included tinnitus, neutropenia, rash, and possible nephrotoxicity. Tolerance (a minimal bactericidal concentration to minimal inhibitory concentration ratio of at least 32), but not a minimal bactericidal concentration of at least 32 mg/L, correlated with therapeutic failure (respectively, p = 0.04 and p = 0.11, Fisher's exact test). Bacteremic infections due to methicillin-resistant and methicillin-sensitive S. aureus cause similar morbidity and mortality. Vancomycin is effective but potentially toxic therapy for most serious infections due to methicillin-resistant S. aureus. In-vitro tests may not predict therapeutic efficacy.
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Cites
"Celbenin" - resistant Staphylococci
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Antibiotic sensitivity testing. Report of an international collaborative study.
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Risdall, R. J., McKenna, R. W., Nesbit, M. E., Krivit, W., Balfour, H. H., Simmons, R. L., & Brunning, R. D. (1979) · Cancer · doi:10.1002/1097-0142(197909)44:3<993::aid-cncr2820440329>3.0.co;2-5 · Cited by 1,050
Swinscow, T. D. V., & Campbell, M. J. (1976) · Cited by 757
Methicillin-Resistant Staphylococcus aureus: Introduction and Spread Within a Hospital
PEACOCK, J. E., MARSIK, F. J., & WENZEL, R. P. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-4-526 · Cited by 391
Crossley, K., Loesch, D., Landesman, B., Mead, K., Chern, M., & Strate, R. (1979) · Journal of Infectious Diseases · doi:10.1093/infdis/139.3.273 · Cited by 390
Staphylococcus aureus bacteremia
Nolan, C. M., & Beaty, H. N. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90715-4 · Cited by 314
The Nephrotoxicity of Antimicrobial Agents
Appel, G. B., & Neu, H. C. (1977) · New England Journal of Medicine · doi:10.1056/nejm197703312961305 · Cited by 310
Klimek, J. J., Marsik, F. J., Bartlett, R. C., Weir, B., Shea, P., & Quintiliani, R. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90370-3 · Cited by 236
GROWING CLINICAL SIGNIFICANCE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
Jack Benner, E., & Kayser, F. H. (1968) · The Lancet · doi:10.1016/s0140-6736(68)90947-1 · Cited by 206
Cited by
Antimicrobial resistance of Staphylococcus aureus: genetic basis
Lyon, B. R., & Skurray, R. A. (1987) · Microbiological Reviews · doi:10.1128/mmbr.51.1.88-134.1987 · Cited by 686
Cong, Y., Yang, S., & Rao, X. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2019.10.005 · Cited by 527
Vancomycin resistance in Staphylococcus aureus
Appelbaum, P. C., & Bozdogan, B. (2004) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2004.03.004 · Cited by 485
Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin
French, G. L. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl393 · Cited by 441
Rello, J., Torres, A., Ricart, M., Valles, J., Gonzalez, J., Artigas, A., & Rodriguez-Roisin, R. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.6.7952612 · Cited by 425
Metadata
- Authors
- SORRELL, T. C., PACKHAM, D. R., SHANKER, S., FOLDES, M., & MUNRO, R.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1982-09-01
- Volume
- 97
- Issue
- 3
- Pages
- 344-350
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2062001308
- Cited by
- 260
- References
- 28
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Vancomycin Therapy for Methicillin-Resistant Staphylococcus aureus. https://app.cochat.ai/papers/10.7326/0003-4819-97-3-344
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- SORRELL, T. C., PACKHAM, D. R., SHANKER, S., FOLDES, M., & MUNRO, R. (1982). Vancomycin Therapy for Methicillin-Resistant Staphylococcus aureus. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-97-3-344
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
