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Cited by 310

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

The Nephrotoxicity of Antimicrobial Agents

Appel, Gerald B., Neu, Harold C.·1977·New England Journal of Medicine

Abstract

VancomycinVancomycin is excreted chiefly by the kidney, with more than 80 per cent of the administered dose recovered in the urine within 24 hours.84 Its half-life is six hours. In patients with impaired renal function, very high serum concentrations accumulate,85 , 86 and the drug is not removed by either hemodialysis or peritoneal dialysis.Animal studies have found vancomycin to have little nephrotoxicity, although the highest concentrations of vancomycin are recovered in the kidneys of the animals post mortem.87 , 88 Although ototoxicity due to vancomycin has been clearly established in man, nephrotoxicity has not. Direct injection of 2-g doses intravenously into healthy . . .

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Crossref · 10.1056/nejm197703312961305

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Metadata

Authors
Appel, G. B., & Neu, H. C.
Venue
New England Journal of Medicine
Published
1977-03-31
Volume
296
Issue
13
Pages
722-728
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2026326627
Cited by
310
References
36
FWCI
30.93
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Nephrotoxicity of Antimicrobial Agents. https://app.cochat.ai/papers/10.1056/nejm197703312961305
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Appel, G. B., & Neu, H. C. (1977). The Nephrotoxicity of Antimicrobial Agents. New England Journal of Medicine. https://doi.org/10.1056/nejm197703312961305

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.