Preventing HIV among adolescents with oral PrEP: observations and challenges in the United States and South Africa
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Introduction: Adolescents and young adults aged <25 are a key population in the HIV epidemic, with very high HIV incidence rates in many geographic settings and a large number who have limited access to prevention services. Thus, any biomedical HIV prevention approach should prepare licensure and implementation strategies for young populations. Oral pre‐exposure prophylaxis (PrEP) is the first antiretroviral‐based prevention intervention with proven efficacy across many settings and populations, and regulatory and policy approvals at global and national levels are occurring rapidly. We discuss available data from studies in the United States and South Africa on the use of oral PrEP for HIV prevention in adolescent minors, along with some of the implementation challenges. Discussion: Ongoing studies in the United States and South Africa among youth under the age of 18 should provide the safety data needed by the end of 2016 to contribute to licensure of Truvada as daily PrEP in adolescents. The challenges of completing these studies as well as foreseeable broader challenges highlighted by this work are presented. Adherence to daily PrEP is a greater challenge for younger populations, and poor adherence was associated with decreased efficacy in all PrEP trials. Individual‐level barriers include limited familiarity with antiretroviral‐based prevention, stigma, product storage, and social support. Structural challenges include healthcare financing for PrEP, clinician acceptability and comfort with PrEP delivery, and the limited youth‐friendly health services available. These challenges are discussed in the context of the work done to date in the United States and South Africa, but will likely be magnified in the setting of limited resources in many other countries that are heavily impacted by HIV. Conclusions: Adolescent populations are particularly vulnerable to HIV, and oral PrEP in these populations is likely to have an impact on population‐level HIV incidence. The challenges of disseminating an HIV biomedical prevention tool requiring daily usage in adolescents are formidable, but addressing these issues and starting dialogues will lay the groundwork for the many other HIV prevention tools now being developed and tested.
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Given that state laws and regulations vary in terms of parental consent requirements for medical services, PrEP implementation in adolescents requires different strategies and research that can inform effective delivery.
“Given that state laws and regulations vary in terms of parental consent requirements for medical services, PrEP implementation in this new population requires different strategies and research that can inform effective delivery [35–37].”
From “Scaling-out” evidence-based interventions to new populations or new health care delivery systems (2017) · cites this paper as [37]
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Tenofovir-based preexposure prophylaxis for HIV infection among African women.
Marrazzo, J. M., Ramjee, G., Richardson, B. A., Gomez, K., Mgodi, N., Nair, G., Palanee, T., Nakabiito, C., van der Straten, A., Noguchi, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1402269 · Cited by 1,296 · see citing works
Jewkes, R. K., Dunkle, K., Nduna, M., & Shai, N. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60548-x · Cited by 1,215 · see citing works
Health for the World’s adolescents: A second chance in the second decade
Dick, B., & Ferguson, B. J. (2015) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2014.10.260 · Cited by 959 · see citing works
Use of a vaginal ring containing dapivirine for HIV-1 prevention in women.
Baeten, J. M., Palanee-Phillips, T., Brown, E. R., Schwartz, K., Soto-Torres, L. E., Govender, V., Mgodi, N. M., Matovu Kiweewa, F., Nair, G., Mhlanga, F., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506110 · Cited by 772 · see citing works
Self-citationAdolescent risk taking, impulsivity, and brain development: Implications for prevention
Romer, D. (2010) · Developmental Psychobiology · doi:10.1002/dev.20442 · Cited by 691 · see citing works
Adolescent girls and young women: key populations for HIV epidemic control
Dellar, R. C., Dlamini, S., & Karim, Q. A. (2015) · Journal of the International AIDS Society · doi:10.7448/ias.18.2.19408 · Cited by 492 · see citing works
The intersection of intimate partner violence against women and HIV/AIDS: a review
Campbell, J. C., Baty, M. L., Ghandour, R. M., Stockman, J. K., Francisco, L. V., & Wagman, J. A. (2008) · International Journal of Injury Control and Safety Promotion · doi:10.1080/17457300802423224 · Cited by 459 · see citing works
Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women
Baeten, J. M., Palanee‐Phillips, T., Brown, E. R., Schwartz, K. D., Soto-Torres, L. E., Govender, V., Mgodi, N. M., Kiweewa, F. M., Nair, G., Mhlanga, F., et al. (2016) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000489577.60775.40 · Cited by 373 · see citing works
Self-citationAn HIV Preexposure Prophylaxis Demonstration Project and Safety Study for Young MSM
Hosek, S., Rudy, B. J., Landovitz, R. J., Kapogiannis, B. G., Siberry, G. K., Rutledge, B. N., Liu, N., Brothers, J., Mulligan, K. M., Zimet, G. D., et al. (2016) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001179 · Cited by 267 · see citing works
Self-citationSullivan, P. S., Rosenberg, E. S., Sanchez, T., Kelley, C. F., Luisi, N., Cooper, H. L. F., DiClemente, R. J., Wingood, G. M., Frew, P. M., Salazar, L. F., et al. (2015) · Annals of Epidemiology · doi:10.1016/j.annepidem.2015.03.006 · Cited by 215 · see citing works
Smith, A. R., Chein, J., & Steinberg, L. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.03.006 · Cited by 214 · see citing works
Karris, M., Beekmann, S. E., Mehta, S., Anderson, C. M., & Polgreen, P. M. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit796 · Cited by 184 · see citing works
Current Concepts for PrEP Adherence
Haberer, J. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000220 · Cited by 154 · see citing works
Adolescent cognitive control and reward processing: Implications for risk taking and substance use
Geier, C. F. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.02.008 · Cited by 144 · see citing works
Seidman, D. L., Carlson, K., Weber, S., Witt, J. S., & Kelly, P. J. (2016) · Contraception · doi:10.1016/j.contraception.2015.12.018 · Cited by 139 · see citing works
Implementation and Operational Research
Grimsrud, A., Lesosky, M., Kalombo, C. D., Bekker, L., & Myer, L. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000863 · Cited by 136 · see citing works
Self-citationHallett, T. B., Gregson, S., Lewis, J. J., Lopman, B. A., & Garnett, G. P. (2007) · Sexually Transmitted Infections · doi:10.1136/sti.2006.023606 · Cited by 112 · see citing works
Hawkins, K., Price, N., & Mussa, F. (2009) · Global Public Health · doi:10.1080/17441690701589813 · Cited by 99 · see citing works
Lane, T., Osmand, T., Marr, A., Shade, S. B., Dunkle, K., Sandfort, T. G. M., Struthers, H. E., Kegeles, S. M., & McIntyre, J. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111063 · Cited by 77 · see citing works
Mimiaga, M. J., Hughto, J. M. W., Krakower, D., Biello, K. B., & Mayer, K. H. (2013) · AIDS Care · doi:10.1080/09540121.2013.845289 · Cited by 70 · see citing works
Bango, F., Ashmore, J., Wilkinson, L. S., Cutsem, G. V., & Cleary, S. (2016) · Tropical Medicine & International Health · doi:10.1111/tmi.12736 · Cited by 70 · see citing works
“Same-Sex Relationship in a Straight World”
Kubicek, K., McNeeley, M., & Collins, S. (2015) · Journal of Interpersonal Violence · doi:10.1177/0886260514532527 · Cited by 68 · see citing works
State Adolescent Consent Laws and Implications for HIV Pre-Exposure Prophylaxis
Culp, L., & Caucci, L. (2013) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.09.044 · Cited by 54 · see citing works
Mullins, T. L. K., Lally, M., Zimet, G. D., Kahn, J. A., & the Adolescent Medicine Trials Network for HIV/AIDS Interventions (2015) · AIDS Patient Care and STDs · doi:10.1089/apc.2014.0273 · Cited by 53 · see citing works
Moore, Q. L., Paul, M. E., McGuire, A. L., & Majumder, M. A. (2015) · American Journal of Public Health · doi:10.2105/ajph.2015.302940 · Cited by 47 · see citing works
Adolescent Self-Consent for Biomedical Human Immunodeficiency Virus Prevention Research
Gilbert, A. L., Knopf, A., Fortenberry, J. D., Hosek, S., Kapogiannis, B. G., & Zimet, G. D. (2015) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2015.03.017 · Cited by 36 · see citing works
Self-citationRoss, E. L., Cinti, S. K., & Hutton, D. W. (2016) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000987 · Cited by 35 · see citing works
Jewell, B. L., Cremin, Í., Pickles, M., Celum, C., Baeten, J. M., Delany‐Moretlwe, S., & Hallett, T. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115511 · Cited by 24 · see citing works
Self-citationThe Impact and Cost of the HIV/AIDS Investment Framework for Adolescents
Stover, J., Rosen, J., Kasedde, S., Idele, P., & McClure, C. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000174 · Cited by 15 · see citing works
PrEP and Our Youth: Implications in Law and Policy
Burda, J. P. (2019) · Columbia Journal of Gender and Law · doi:10.7916/cjgl.v30i2.2731 · Cited by 6 · see citing works
Gilbert, A. L., Knopf, A., Fortenberry, J. D., Kapogiannis, B. G., Hosek, S., & Zimet, G. D. (2015) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2014.10.028 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- [20]Gill K Marcus R Dietrich J Bennie T Hosek S Gray G An analysis of baseline and early data from the Plus Pills study: an open-label trial of pre-exposure prophylaxis for South African adolescents In International AIDS Conference 2016 July 19 Durban
- [24]WHO Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV 2015 Geneva, Switzerland 26598776
- [33]Knopf A Ott M Liu N Kapogiannis B Zimet G Fortenberry D Unexpected benefits and heightened disclosure risks: adolescents’ experiences in a PrEP trial International AIDS Conference 2016 July 19 Durban
- [42]Bekker LG Hughes J Amico R Roux S Hendrix C Anderson PL HPTN 067/ADAPT Cape Town: a comparison of daily and nondaily PrEP dosing in African women Conference on Retroviruses and Opportunistic Infections (CROI) 2015 Feb 23 San Francisco CA, USA: International AIDS Society 23 6
Cited by
Sorted by citations
“Scaling-out” evidence-based interventions to new populations or new health care delivery systems
Aarons, G. A., Sklar, M., Mustanski, B., Benbow, N., & Brown, C. H. (2017) · Implementation Science · doi:10.1186/s13012-017-0640-6 · Cited by 399 · see citing works
Improving PrEP Implementation Through Multilevel Interventions: A Synthesis of the Literature
Pinto, R. M., Berringer, K. R., Melendez, R. M., & Mmeje, O. O. (2018) · AIDS and Behavior · doi:10.1007/s10461-018-2184-4 · Cited by 245 · see citing works
Hosek, S., Landovitz, R. J., Kapogiannis, B. G., Siberry, G. K., Rudy, B. J., Rutledge, B. N., Liu, N., Harris, D. R., Mulligan, K. M., Zimet, G. D., et al. (2017) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.2007 · Cited by 222 · see citing works
Self-citationSullivan, P. S., Mera, R. M., Mouhanna, F., Pembleton, E. S., Guest, J. L., Jones, J. S., Castel, A. D., Yeung, H., Kramer, M. R., McCallister, S. H., et al. (2018) · Annals of Epidemiology · doi:10.1016/j.annepidem.2018.06.009 · Cited by 211 · see citing works
Implementation Research Methodologies for Achieving Scientific Equity and Health Equity
McNulty, M., Smith, J. D., Villamar, J. A., Burnett‐Zeigler, I., Vermeer, W., Benbow, N., Gallo, C. G., Wilensky, U. J., Hjorth, A., Mustanski, B. S., et al. (2019) · Ethnicity & Disease · doi:10.18865/ed.29.s1.83 · Cited by 150 · see citing works
Pettifor, A. E., Stoner, M. C. D., Pike, C., & Bekker, L. (2018) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000453 · Cited by 152 · see citing works
Self-citationSerota, D. P., Rosenberg, E. S., Sullivan, P. S., Thorne, A. L., Rolle, C.-P., del Rı́o, C., Cutro, S. R., Luisi, N., Siegler, A. J., Sanchez, T., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz894 · Cited by 135 · see citing works
Coy, K. C., Hazen, R. J., Kirkham, H. S., Delpino, A., & Siegler, A. J. (2019) · Journal of the International AIDS Society · doi:10.1002/jia2.25252 · Cited by 126 · see citing works
Is Insurance a Barrier to HIV Preexposure Prophylaxis? Clarifying the Issue
Kay, E. S., & Pinto, R. M. (2019) · American Journal of Public Health · doi:10.2105/ajph.2019.305389 · Cited by 126 · see citing works
van der Straten, A., Agot, K. E., Ahmed, K., Weinrib, R., Browne, E. N., Manenzhe, K. N., Owino, F., Schwartz, J. L., Minnis, A. M., & on behalf of the TRIO Study Team (2018) · Journal of the International AIDS Society · doi:10.1002/jia2.25094 · Cited by 109 · see citing works
Hojilla, J. C., Hurley, L. B., Marcus, J. L., Silverberg, M. J., Skarbinski, J., Satre, D. D., & Volk, J. E. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.22692 · Cited by 102 · see citing works
Macapagal, K. R., Kraus, A., Korpak, A. K., Jozsa, K., & Moskowitz, D. (2019) · Archives of Sexual Behavior · doi:10.1007/s10508-019-1429-2 · Cited by 98 · see citing works
Reback, C. J., Clark, K. A., Rünger, D., & Fehrenbacher, A. E. (2019) · Journal of Community Health · doi:10.1007/s10900-019-00705-x · Cited by 86 · see citing works
Biello, K. B., Hosek, S., Drucker, M. T., Belzer, M. E., Mimiaga, M. J., Marrow, E., Coffey-Esquivel, J., Brothers, J., & Mayer, K. H. (2017) · Archives of Sexual Behavior · doi:10.1007/s10508-017-1049-7 · Cited by 81 · see citing works
Self-citationDunbar, M. S., Kripke, K. E., Haberer, J. E., Castor, D., Dalal, S., Mukoma, W., Mullick, S., Patel, P., Reed, J. B., Subedar, H., et al. (2018) · Sexual Health · doi:10.1071/sh18061 · Cited by 78 · see citing works
Rousseau, E., Julies, R. F., Madubela, N., & Kassim, S. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00578-7 · Cited by 77 · see citing works
Chua, C. Y. X., Jain, P., Ballerini, A., Bruno, G., Hood, R. L., Gupte, M., Gao, S., Trani, N. D., Šušnjar, A., Shelton, K. A., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.010 · Cited by 76 · see citing works
Giovenco, D., Gill, K., Fynn, L., Duyver, M., O’Rourke, S., van der Straten, A., Morton, J. F., Celum, C., & Bekker, L. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248307 · Cited by 69 · see citing works
Self-citationGill, K., Johnson, L. F., Dietrich, J. J., Myer, L., Marcus, R., Wallace, M., Pidwell, T., Mendel, E., Fynn, L., Jones, K. A., et al. (2020) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(20)30248-0 · Cited by 64 · see citing works
Self-citationHIV Preexposure Prophylaxis Among Adolescents in the US
Yusuf, H. E., Fields, E. L., Arrington‐Sanders, R., Griffith, D., & Agwu, A. L. (2020) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2020.0824 · Cited by 56 · see citing works
PrEP as a Lifestyle and Investment for Adolescent Girls and Young Women in Sub-Saharan Africa
Haberer, J. E., Mugo, N., Baeten, J. M., Pyra, M. N., Bukusi, E. A., & Bekker, L. (2019) · Journal of the International Association of Providers of AIDS Care (JIAPAC) · doi:10.1177/2325958219831011 · Cited by 56 · see citing works
Self-citationLanham, M., Ridgeway, K., Mireku, M., Nhamo, D., Pillay, D., Murire, M., Stankevitz, K., Kyongo, J. K., Mullick, S., Bhatasara, T., et al. (2021) · BMC Health Services Research · doi:10.1186/s12913-021-06978-0 · Cited by 57 · see citing works
Duby, Z., Bunce, B., Fowler, C., Jonas, K., Bergh, K., Govindasamy, D., Wagner, C., & Mathews, C. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03750-1 · Cited by 54 · see citing works
Hightow‐Weidman, L., Muessig, K. E., Rosenberg, E. S., Sanchez, T., LeGrand, S., Gravens, L., & Sullivan, P. S. (2018) · JMIR Research Protocols · doi:10.2196/10365 · Cited by 48 · see citing works
Dourado, I. C., Magno, L., Greco, D. B., Zucchi, E. M., Ferraz, D., Westin, M. R., & Grangeiro, A. (2023) · Cadernos de Saúde Pública · doi:10.1590/0102-311xen143221 · Cited by 47 · see citing works
The ongoing HIV epidemic in American youth: challenges and opportunities
Allan‐Blitz, L., Mena, L. A., & Mayer, K. H. (2021) · mHealth · doi:10.21037/mhealth-20-42 · Cited by 46 · see citing works
(2018) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2018.07.021 · Cited by 46 · see citing works
Delivering preexposure prophylaxis to pregnant and breastfeeding women in Sub-Saharan Africa
Davey, D. J., Bekker, L., Gorbach, P. M., Coates, T. J., & Myer, L. (2017) · AIDS · doi:10.1097/qad.0000000000001604 · Cited by 44 · see citing works
Self-citationShapley‐Quinn, M. K., Manenzhe, K. N., Agot, K. E., Minnis, A. M., & van der Straten, A. (2019) · International Journal of Women s Health · doi:10.2147/ijwh.s185712 · Cited by 45 · see citing works
Macapagal, K. R., Nery-Hurwit, M. B., Matson, M., Crosby, S. T., & Greene, G. J. (2020) · Sexuality Research and Social Policy · doi:10.1007/s13178-020-00441-1 · Cited by 42 · see citing works
Taggart, T., Bond, K. T., Ritchwood, T. D., & Smith, J. C. (2019) · Journal of the International AIDS Society · doi:10.1002/jia2.25363 · Cited by 41 · see citing works
Bjertrup, P. J., Mmema, N., Dlamini, V., Ciglenečki, I., Mpala, Q., Matse, S., Kerschberger, B., & Wringe, A. (2021) · BMC Public Health · doi:10.1186/s12889-021-10766-0 · Cited by 40 · see citing works
Chetty, T., Vandormael, A. M., Thorne, C., & Coutsoudis, A. (2017) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-017-1421-6 · Cited by 37 · see citing works
Giovenco, D., Pettifor, A. E., MacPhail, C. L., Kahn, K., Wagner, R. G., Piwowar‐Manning, E., Wang, J., & Hughes, J. P. (2019) · Journal of the International AIDS Society · doi:10.1002/jia2.25359 · Cited by 37 · see citing works
Makhakhe, N. F., Sliep, Y., & Meyer‐Weitz, A. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.691729 · Cited by 34 · see citing works
Holt, B. Y., Turpin, J. A., & Romano, J. (2021) · Frontiers in Reproductive Health · doi:10.3389/frph.2021.704841 · Cited by 34 · see citing works
Preexposure Prophylaxis of HIV Infection: the Role of Clinical Practices in Ending the HIV Epidemic
Zablotska, I., & O'Connor, C. C. (2017) · Current HIV/AIDS Reports · doi:10.1007/s11904-017-0367-7 · Cited by 32 · see citing works
Maria, D. S., Flash, C. A., Narendorf, S. C., Barman‐Adhikari, A., Petering, R., Hsu, H.-T., Shelton, J., Bender, K., & Ferguson, K. M. (2018) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2018.06.023 · Cited by 31 · see citing works
Provider Comfort with Prescribing HIV Pre-Exposure Prophylaxis to Adolescents
Pina, P. R., Taggart, T., Acosta, M. S., Eweka, I., Muñoz‐Laboy, M., & Albritton, T. (2021) · AIDS Patient Care and STDs · doi:10.1089/apc.2021.0045 · Cited by 30 · see citing works
Dauria, E., Levine, A., Hill, S. V., Tolou‐Shams, M., & Christopoulos, K. (2020) · Archives of Sexual Behavior · doi:10.1007/s10508-020-01834-4 · Cited by 30 · see citing works
Stankevitz, K., Schwartz, K. D., Hoke, T., Li, Y., Lanham, M., Mahaka, I. C., & Mullick, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218556 · Cited by 28 · see citing works
Smith, P. J., Tolla, T. H., Marcus, R., & Bekker, L. (2019) · BMC Health Services Research · doi:10.1186/s12913-019-4423-4 · Cited by 29 · see citing works
Self-citationPrEP 1.0 and Beyond: Optimizing a Biobehavioral Intervention
Mayer, K., & Allan-Blitz, L. (2019) · Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002169 · Cited by 24 · see citing works
Little, K. M., Flomen, L., Hanif, H., Anderson, S. M., Thurman, A. R., Clark, M. R., & Doncel, G. F. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03658-w · Cited by 28 · see citing works
Roberts, S. T., Mancuso, N., Williams, K., Nabunya, H. K., Mposula, H., Mugocha, C., Mvinjelwa, P., Garcia, M., Szydlo, D. W., Soto-Torres, L. E., et al. (2023) · Journal of the International AIDS Society · doi:10.1002/jia2.26189 · Cited by 27 · see citing works
Self-citation‘This is mine, this is for me’
Bärnighausen, K., Matse, S., Kennedy, C. E., Lejeune, C. L., Hughey, A. B., Hettema, A., Bärnighausen, T., & McMahon, S. A. (2019) · AIDS · doi:10.1097/qad.0000000000002178 · Cited by 27 · see citing works
Reaching key adolescent populations
Cornell, M., & Dovel, K. L. (2018) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000457 · Cited by 26 · see citing works
Puppo, C., Spire, B., Morel, S., Algarté-Génin, M., Béniguel, L., Costagliola, D. G., Ghosn, J., Mabire, X., Molina, J., Castro, D. R., et al. (2020) · AIDS Care · doi:10.1080/09540121.2020.1742863 · Cited by 26 · see citing works
Pleaner, M., Fipaza, Z., Mabetha, K., Greener, L. R., Ncube, S., Butler, V., Beksinska, M. E., & Mullick, S. (2021) · Frontiers in Reproductive Health · doi:10.3389/frph.2021.684114 · Cited by 22 · see citing works
Velloza, J., Kapogiannis, B. G., Bekker, L., Celum, C., Hosek, S., Delany‐Moretlwe, S., Baggaley, R. C., & Dalal, S. (2020) · AIDS · doi:10.1097/qad.0000000000002777 · Cited by 23 · see citing works
Self-citationCalder, B. J., Schieffer, R. J., Tfaily, E. B., D’Aquila, R. T., Greene, G. J., Carballo‐Diéguez, A., Giguere, R., Kiser, P. F., & Hope, T. J. (2018) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2018.0214 · Cited by 21 · see citing works
Sosnowy, C. D., Predmore, Z., Dean, L. T., Raifman, J., Chu, C. T., Galipeau, D., Nocka, K., Napoleon, S. C., & Chan, P. A. (2022) · International Journal of STD & AIDS · doi:10.1177/09564624221132406 · Cited by 20 · see citing works
Velloza, J., Poovan, N., Ndlovu, N., Khoza, N., Morton, J. F., Omony, J., Mkwanazi, E., Grabow, C., Donnell, D. J., Munthali, R. J., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266665 · Cited by 20 · see citing works
Self-citationWarzywoda, S., Fowler, J. A., Dyda, A., Fitzgerald, L., Mullens, A. B., & Dean, J. A. (2024) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361241303415 · Cited by 19 · see citing works
Oostrom, L. A., Rosentel, K., Motley, D., & Hill, B. J. (2019) · Journal of the Association of Nurses in AIDS Care · doi:10.1097/jnc.0000000000000137 · Cited by 18 · see citing works
Fitch, C., Haberer, J. E., Serrano, P. A., Muñoz, A., French, A. L., & Hosek, S. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03656-y · Cited by 17 · see citing works
Self-citationInterest in HIV pre-exposure prophylaxis (PrEP) among adolescents and their caregivers in Malawi
Kidman, R. C., Nachman, S., & Kohler, H. (2020) · AIDS Care · doi:10.1080/09540121.2020.1742861 · Cited by 16 · see citing works
Katz, A. W. K., Roberts, S. T., Rousseau, E., Ndimande-Khoza, M. N., Mogaka, F. O., Bukusi, E. A., Delany‐Moretlwe, S., Bekker, L., Morton, J. F., Johnson, R. E., et al. (2022) · Journal of the Association of Nurses in AIDS Care · doi:10.1097/jnc.0000000000000363 · Cited by 16 · see citing works
Self-citationMcKetchnie, S. M., White, B. P., Fontenot, H. B., Dormitzer, J., Psaros, C., Fitch, C., O’Cleirigh, C. M., Mayer, K. H., & Krakower, D. (2023) · Archives of Sexual Behavior · doi:10.1007/s10508-023-02579-6 · Cited by 16 · see citing works
Oliveira, R. L. E. S. E., da Silva, L. A. V., Duarte, F. M., Brasil, S. A., Castellanos, M. E. P., Magno, L., & Dourado, I. C. (2023) · Cadernos de Saúde Pública · doi:10.1590/0102-311xen176821 · Cited by 16 · see citing works
Knowledgeable, aware / interested: Young black women's perceptions of pre-exposure prophylaxis
Haider, S., Friedman, E. E., Ott, E., Moore, A., Pandiani, A., Desmarais, C., & Johnson, A. K. (2022) · Frontiers in Reproductive Health · doi:10.3389/frph.2022.671009 · Cited by 15 · see citing works
Husnik, M. J., Brown, E. R., Marzinke, M. A., Livant, E., Palanee‐Phillips, T., Hendrix, C. W., Kiweewa, F. M., Nair, G., Soto-Torres, L. E., Schwartz, K. D., et al. (2017) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001503 · Cited by 15 · see citing works
Trends in HIV pre-exposure prophylaxis use in eight Canadian provinces, 2014–2018
Popovic, N., Yang, Q., & Archibald, C. P. (2021) · Canada Communicable Disease Report · doi:10.14745/ccdr.v47i56a02 · Cited by 15 · see citing works
Birnholtz, J. P., Kraus, A., Schnuer, S., Tran, L., Macapagal, K. R., & Moskowitz, D. (2021) · Culture Health & Sexuality · doi:10.1080/13691058.2021.1975825 · Cited by 15 · see citing works
Giovenco, D., Kuo, C., Underhill, K., Hoare, J., & Operario, D. (2021) · Archives of Sexual Behavior · doi:10.1007/s10508-021-02052-2 · Cited by 15 · see citing works
Implications for PrEP Uptake in Young Adults Experiencing Homelessness: A Mixed Methods Study
Maria, D. S., Gallardo, K. R., Narendorf, S. C., Petering, R., Barman‐Adhikari, A., Flash, C. A., Hsu, H.-T., Shelton, J., Ferguson, K. M., & Bender, K. (2019) · AIDS Education and Prevention · doi:10.1521/aeap.2019.31.1.63 · Cited by 15 · see citing works
Zhang, L., Song, Y., Zheng, X., Liu, Y., & Chen, H. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1224461 · Cited by 15 · see citing works
Giovenco, D., Pettifor, A. E., Powers, K. A., Hightow‐Weidman, L., Pence, B. W., Edwards, J. K., Gill, K., Morton, J. F., van der Straten, A., Celum, C., et al. (2021) · AIDS and Behavior · doi:10.1007/s10461-021-03455-x · Cited by 14 · see citing works
Self-citationNo one left behind: how are we doing in the roll‐out of PrEP as part of combination HIV prevention?
Cáceres, C. F., Bekker, L., & Godfrey‐Faussett, P. (2016) · Journal of the International AIDS Society · doi:10.7448/ias.19.7.21364 · Cited by 13 · see citing works
Self-citationGiovenco, D., Kuo, C., Underhill, K., Hoare, J., & Operario, D. (2018) · AIDS Education and Prevention · doi:10.1521/aeap.2018.30.6.463 · Cited by 12 · see citing works
Adolescent Preexposure Prophylaxis Administration: An Education Curriculum for Health Care Providers
Carnevale, C., Zucker, J. E., Womack, J. A., Dixon, J. K., COHALL, A. T., Sobieszczyk, M. E., & Gordon, P. C. (2018) · Journal of Pediatric Health Care · doi:10.1016/j.pedhc.2018.09.007 · Cited by 12 · see citing works
Hill, S. V., Westfall, A. O., Coyne-Beasley, T. D., Simpson, T. Y., & Elopre, L. E. (2019) · Sexually Transmitted Diseases · doi:10.1097/olq.0000000000001104 · Cited by 12 · see citing works
Biello, K. B., Valente, P. K., Lin, W., Lodge, W., Drab, R., Hightow‐Weidman, L., da Silva, D. T., Mayer, K. H., & Bauermeister, J. A. (2021) · AIDS and Behavior · doi:10.1007/s10461-021-03545-w · Cited by 12 · see citing works
Maria, D. S., Lightfoot, M. A., Nyamathi, A., Businelle, M. S., Paul, M. E., Quadri, Y., Padhye, N. S., Jones, J. D. T., & Armijo, M. C. (2021) · JMIR Research Protocols · doi:10.2196/26716 · Cited by 11 · see citing works
The Role of Families in Adolescent and Young Adults’ PrEP Use
Atujuna, M., Montgomery, E., Hartmann, M., Ndwayana, S., Browne, E. N., Sindelo, S., Bekker, L., & Minnis, A. M. (2021) · AIDS and Behavior · doi:10.1007/s10461-021-03514-3 · Cited by 11 · see citing works
Self-citationHeck, C. J., Mathur, S., Alwang’a, H., Oluoch-Madiang, D., Obanda, R., Owiti, M., & Okal, J. O. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03590-z · Cited by 11 · see citing works
Johnson, A. K., Ott, E., Friedman, E. E., Pandiani, A., Moore, A., Alvarez, I., Desmarais, C., & Haider, S. (2025) · BMJ Public Health · doi:10.1136/bmjph-2023-000809 · Cited by 10 · see citing works
Mocorro, I. G., Sandhu, P., Rowniak, S. R., & Leonard, A. (2020) · Journal of the American Association of Nurse Practitioners · doi:10.1097/jxx.0000000000000485 · Cited by 10 · see citing works
Lane, J., Brezak, A., Patel, P., Verani, A. R., Benech, I., & Katz, A. B. (2021) · The International Journal of Health Planning and Management · doi:10.1002/hpm.3252 · Cited by 10 · see citing works
DISCOVER: much accomplished, but not yet for all
Spiegel, H. M. L. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31530-0 · Cited by 10 · see citing works
Skovdal, M., Sørensen, O. N. K., Muchemwa, D., Nyamwanza, R. P., Maswera, R., Svendsen, M. N., Nyamukapa, C. A., Thomas, R., & Gregson, S. (2022) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2022.10.008 · Cited by 9 · see citing works
Preventing HIV Infection in High-Risk Adolescents Using Preexposure Prophylaxis (PrEP)
Blackwell, C. W. (2018) · Journal of the Association of Nurses in AIDS Care · doi:10.1016/j.jana.2018.06.001 · Cited by 9 · see citing works
Stoner, M. C. D., Bhushan, N. L., Maragh‐Bass, A. C., Mitchell, J. T., Riggins, L., Walker, M., LeMasters, K. H., Reese, B. M., Dearing, A., Debnam, S., et al. (2021) · AIDS and Behavior · doi:10.1007/s10461-021-03519-y · Cited by 8 · see citing works
Davey, D. J., Wilkinson, L. S., Grimsrud, A., Nelson, A., Gray, A., Raphael, Y., Wattrus, C., Pillay, Y. G., & Bekker, L. (2023) · South African Medical Journal · doi:10.7196/samj.2023.v113i8.1191 · Cited by 7 · see citing works
Self-citationCogordan, C., Fressard, L., Brosset, E., Bocquier, A., Velter, A., Annequin, M., Bourrelly, M., Constance, J., Michels, D., Mora, M., et al. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2348845 · Cited by 7 · see citing works
Maria, D. S., Nyamathi, A., Lightfoot, M. A., Paul, M. E., Quadri, Y., Padhye, N. S., Businelle, M. S., Sánchez, H. F., & Jones, J. T. (2024) · AIDS and Behavior · doi:10.1007/s10461-024-04544-3 · Cited by 7 · see citing works
Pre-exposure Prophylaxis as HIV Prevention in High Risk Adolescents
Gray, M. E. (2018) · Journal of Pediatrics and Pediatric Medicine · doi:10.29245/2578-2940/2018/1.1108 · Cited by 7 · see citing works
Watson, D. L., Shaw, P. A., Petsis, D. T., Pickel, J., Bauermeister, J. A., Frank, I., Wood, S. M., & Gross, R. (2022) · Journal of the International AIDS Society · doi:10.1002/jia2.25867 · Cited by 7 · see citing works
Narasimhan, M., Pedersen, H., Ogilvie, G. S., & Vermund, S. H. (2017) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/trx032 · Cited by 7 · see citing works
Marhefka, S. L., Green, S. M., Sharma, V., & Mellins, C. A. (2017) · AIDS Care · doi:10.1080/09540121.2017.1300626 · Cited by 6 · see citing works
Crowley, K., DUGAS, M. A., Gao, G. G., Burn, L., Igumbor, K., Njapha, D., Piper, J. M., Veronese, F. D. M., & Agarwal, R. (2021) · Health Marketing Quarterly · doi:10.1080/07359683.2021.2007587 · Cited by 6 · see citing works
Lessons Learned in Centering Youth Voices in HIV Prevention: The Adolescent Health Working Group
Maragh‐Bass, A. C., LeMasters, K., Sanders, T., Harding, C. J., Dearing, A., Purcell, R., Mitchell, J. T., Stoner, M. C. D., Bhushan, N. L., Walker, M., et al. (2022) · Progress in community health partnerships · doi:10.1353/cpr.2022.0076 · Cited by 6 · see citing works
Mathews, C., Lombard, C. J., Puren, A. J., Cheyip, M., Ayalew, K., Jonas, K., Kuo, C., LoVette, A., Beauclair, R., Cawood, C., et al. (2020) · Cited by 6 · see citing works
Self-citationKeyes, J., Crouse, E., DeJesus, E., & Rolle, C.-P. (2020) · Journal of Investigative Medicine · doi:10.1136/jim-2020-001352 · Cited by 5 · see citing works
Long-acting agents for HIV treatment and prevention
Bekker, L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01917-w · Cited by 4 · see citing works
Self-citationGbaja-Biamila, T. A., Obiezu‐Umeh, C., Nwaozuru, U., Rosenberg, N. E., Igbokwe, M. A., Oladele, D. A., Musa, A. Z., Idigbe, I. E., Conserve, D. F., Day, S., et al. (2024) · BMC Health Services Research · doi:10.1186/s12913-024-11459-1 · Cited by 5 · see citing works
Potential Role of Conversational Agents in Encouraging PrEP Uptake
Hassani, M., & Young, S. D. (2022) · The Journal of Behavioral Health Services & Research · doi:10.1007/s11414-022-09798-0 · Cited by 5 · see citing works
DiTullio, D. J., Farley, E., Gomba, Y., Coates, T. J., Bekker, L., Myer, L., & Davey, D. J. (2019) · International Journal of STD & AIDS · doi:10.1177/0956462419863216 · Cited by 5 · see citing works
Self-citationAwareness of and willingness to use HIV pre-exposure prophylaxis among community residents
Ware, K. B., & Ajonina, M. U. (2021) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2021.02.012 · Cited by 4 · see citing works
Addressing Explanation of Benefits as a Barrier to PrEP for Adolescents in Public Health Entities
Hall, E. (2022) · Undergraduate Journal of Public Health · doi:10.3998/ujph.2316 · Cited by 4 · see citing works
- Authors
- Hosek, S., Celum, C., Wilson, C. M., Kapogiannis, B., Delany‐Moretlwe, S., & Bekker, L.
- Affiliations
- John H. Stroger, Jr. Hospital of Cook County (US)
- University of Washington (US)
- University of Alabama at Birmingham (US)
- National Institutes of Health (US)
- University of Cape Town (ZA)
- Corresponding author
- Hosek, Sybil
- Venue
- Journal of the International AIDS Society
- Publisher
- Wiley
- Published
- 2016-10
- Volume
- 19
- Issue
- 7S6
- Pages
- 21107-21107
- ISSN
- 1758-2652 (ISSN-L)
- PMC
- PMC5071778
- OpenAlex
- W2536440088
- Cited by
- 138
- References
- 32
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 19 · 2021: 28 · 2020: 14 · 2019: 19 · 2018: 17 · 2017: 12 · 2016: 2
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of the International AIDS Society (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Health Professions › General Health Professions › Adolescent Sexual and Reproductive Health
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- HIV prevention, oral pre-exposure prophylaxis, adolescents, Truvada, PrEP adherence, youth-friendly health services, HIV stigma, health care financing, clinician acceptability, HIV incidence, United States, South Africa
- MeSH terms
- Adolescent, Adult, Delivery of Health Care, Female, Humans, Male, South Africa, United States, HIV Infections, Anti-HIV Agents, Young Adult, Social Stigma, Pre-Exposure Prophylaxis
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